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Brain Banks Spur New Frontiers in Neuropsychiatric Research and Strategies for Analysis and Validation
Neuropsychiatric disorders affect hundreds of millions of patients and families worldwide. To decode the molecular framework of these diseases, many studies use human postmortem brain samples. These studies reveal brain-specific genetic and epigenetic patterns via high-throughput sequencing technolo...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6943778/ https://www.ncbi.nlm.nih.gov/pubmed/31811942 http://dx.doi.org/10.1016/j.gpb.2019.02.002 |
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author | Wang, Le Xia, Yan Chen, Yu Dai, Rujia Qiu, Wenying Meng, Qingtuan Kuney, Liz Chen, Chao |
author_facet | Wang, Le Xia, Yan Chen, Yu Dai, Rujia Qiu, Wenying Meng, Qingtuan Kuney, Liz Chen, Chao |
author_sort | Wang, Le |
collection | PubMed |
description | Neuropsychiatric disorders affect hundreds of millions of patients and families worldwide. To decode the molecular framework of these diseases, many studies use human postmortem brain samples. These studies reveal brain-specific genetic and epigenetic patterns via high-throughput sequencing technologies. Identifying best practices for the collection of postmortem brain samples, analyzing such large amounts of sequencing data, and interpreting these results are critical to advance neuropsychiatry. We provide an overview of human brain banks worldwide, including progress in China, highlighting some well-known projects using human postmortem brain samples to understand molecular regulation in both normal brains and those with neuropsychiatric disorders. Finally, we discuss future research strategies, as well as state-of-the-art statistical and experimental methods that are drawn upon brain bank resources to improve our understanding of the agents of neuropsychiatric disorders. |
format | Online Article Text |
id | pubmed-6943778 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-69437782020-01-09 Brain Banks Spur New Frontiers in Neuropsychiatric Research and Strategies for Analysis and Validation Wang, Le Xia, Yan Chen, Yu Dai, Rujia Qiu, Wenying Meng, Qingtuan Kuney, Liz Chen, Chao Genomics Proteomics Bioinformatics Review Neuropsychiatric disorders affect hundreds of millions of patients and families worldwide. To decode the molecular framework of these diseases, many studies use human postmortem brain samples. These studies reveal brain-specific genetic and epigenetic patterns via high-throughput sequencing technologies. Identifying best practices for the collection of postmortem brain samples, analyzing such large amounts of sequencing data, and interpreting these results are critical to advance neuropsychiatry. We provide an overview of human brain banks worldwide, including progress in China, highlighting some well-known projects using human postmortem brain samples to understand molecular regulation in both normal brains and those with neuropsychiatric disorders. Finally, we discuss future research strategies, as well as state-of-the-art statistical and experimental methods that are drawn upon brain bank resources to improve our understanding of the agents of neuropsychiatric disorders. Elsevier 2019-08 2019-12-05 /pmc/articles/PMC6943778/ /pubmed/31811942 http://dx.doi.org/10.1016/j.gpb.2019.02.002 Text en © 2019 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Wang, Le Xia, Yan Chen, Yu Dai, Rujia Qiu, Wenying Meng, Qingtuan Kuney, Liz Chen, Chao Brain Banks Spur New Frontiers in Neuropsychiatric Research and Strategies for Analysis and Validation |
title | Brain Banks Spur New Frontiers in Neuropsychiatric Research and Strategies for Analysis and Validation |
title_full | Brain Banks Spur New Frontiers in Neuropsychiatric Research and Strategies for Analysis and Validation |
title_fullStr | Brain Banks Spur New Frontiers in Neuropsychiatric Research and Strategies for Analysis and Validation |
title_full_unstemmed | Brain Banks Spur New Frontiers in Neuropsychiatric Research and Strategies for Analysis and Validation |
title_short | Brain Banks Spur New Frontiers in Neuropsychiatric Research and Strategies for Analysis and Validation |
title_sort | brain banks spur new frontiers in neuropsychiatric research and strategies for analysis and validation |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6943778/ https://www.ncbi.nlm.nih.gov/pubmed/31811942 http://dx.doi.org/10.1016/j.gpb.2019.02.002 |
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