Antidepressant Potential of Cinnamic Acids: Mechanisms of Action and Perspectives in Drug Development

Depression is a health problem that compromises the quality of life of the world′s population. It has different levels of severity and a symptomatic profile that affects social life and performance in work activities, as well as a high number of deaths in certain age groups. In the search for new th...

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Autores principales: Diniz, Lúcio Ricardo Leite, Souza, Marilia Trindade de Santana, Barboza, Joice Nascimento, de Almeida, Reinaldo Nóbrega, de Sousa, Damião Pergentino
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6943791/
https://www.ncbi.nlm.nih.gov/pubmed/31817569
http://dx.doi.org/10.3390/molecules24244469
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author Diniz, Lúcio Ricardo Leite
Souza, Marilia Trindade de Santana
Barboza, Joice Nascimento
de Almeida, Reinaldo Nóbrega
de Sousa, Damião Pergentino
author_facet Diniz, Lúcio Ricardo Leite
Souza, Marilia Trindade de Santana
Barboza, Joice Nascimento
de Almeida, Reinaldo Nóbrega
de Sousa, Damião Pergentino
author_sort Diniz, Lúcio Ricardo Leite
collection PubMed
description Depression is a health problem that compromises the quality of life of the world′s population. It has different levels of severity and a symptomatic profile that affects social life and performance in work activities, as well as a high number of deaths in certain age groups. In the search for new therapeutic options for the treatment of this behavioral disorder, the present review describes studies on antidepressant activity of cinnamic acids, which are natural products found in medicinal plants and foods. The description of the animal models used and the mechanisms of action of these compounds are discussed.
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spelling pubmed-69437912020-01-10 Antidepressant Potential of Cinnamic Acids: Mechanisms of Action and Perspectives in Drug Development Diniz, Lúcio Ricardo Leite Souza, Marilia Trindade de Santana Barboza, Joice Nascimento de Almeida, Reinaldo Nóbrega de Sousa, Damião Pergentino Molecules Review Depression is a health problem that compromises the quality of life of the world′s population. It has different levels of severity and a symptomatic profile that affects social life and performance in work activities, as well as a high number of deaths in certain age groups. In the search for new therapeutic options for the treatment of this behavioral disorder, the present review describes studies on antidepressant activity of cinnamic acids, which are natural products found in medicinal plants and foods. The description of the animal models used and the mechanisms of action of these compounds are discussed. MDPI 2019-12-06 /pmc/articles/PMC6943791/ /pubmed/31817569 http://dx.doi.org/10.3390/molecules24244469 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Diniz, Lúcio Ricardo Leite
Souza, Marilia Trindade de Santana
Barboza, Joice Nascimento
de Almeida, Reinaldo Nóbrega
de Sousa, Damião Pergentino
Antidepressant Potential of Cinnamic Acids: Mechanisms of Action and Perspectives in Drug Development
title Antidepressant Potential of Cinnamic Acids: Mechanisms of Action and Perspectives in Drug Development
title_full Antidepressant Potential of Cinnamic Acids: Mechanisms of Action and Perspectives in Drug Development
title_fullStr Antidepressant Potential of Cinnamic Acids: Mechanisms of Action and Perspectives in Drug Development
title_full_unstemmed Antidepressant Potential of Cinnamic Acids: Mechanisms of Action and Perspectives in Drug Development
title_short Antidepressant Potential of Cinnamic Acids: Mechanisms of Action and Perspectives in Drug Development
title_sort antidepressant potential of cinnamic acids: mechanisms of action and perspectives in drug development
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6943791/
https://www.ncbi.nlm.nih.gov/pubmed/31817569
http://dx.doi.org/10.3390/molecules24244469
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