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The role of melatonin in polycystic ovary syndrome: A review

BACKGROUND: Polycystic ovary syndrome (PCOS) is a widespread endocrine disorder, affecting approximately 20% of women within reproductive age. It is associated with hyperandrogenism, obesity, menstrual irregularity, and anovulatory infertility. Melatonin is the main pineal gland hormone involved in...

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Autores principales: Mojaverrostami, Sina, Asghari, Narjes, Khamisabadi, Mahsa, Heidari Khoei, Heidar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Knowledge E 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6943797/
https://www.ncbi.nlm.nih.gov/pubmed/31970309
http://dx.doi.org/10.18502/ijrm.v17i12.5789
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author Mojaverrostami, Sina
Asghari, Narjes
Khamisabadi, Mahsa
Heidari Khoei, Heidar
author_facet Mojaverrostami, Sina
Asghari, Narjes
Khamisabadi, Mahsa
Heidari Khoei, Heidar
author_sort Mojaverrostami, Sina
collection PubMed
description BACKGROUND: Polycystic ovary syndrome (PCOS) is a widespread endocrine disorder, affecting approximately 20% of women within reproductive age. It is associated with hyperandrogenism, obesity, menstrual irregularity, and anovulatory infertility. Melatonin is the main pineal gland hormone involved in the regulation of the circadian rhythm. In recent years, it has been observed that a reduction in melatonin levels of follicular fluid exists in PCOS patients. Melatonin receptors in the ovary and intra-follicular fluid adjust sex steroid secretion at different phases of ovarian follicular maturation. Moreover, melatonin is a strong antioxidant and an effective free radical scavenger, which protects ovarian follicles during follicular maturation. OBJECTIVE: In this paper, we conducted a literature review and the summary of the current research on the role of melatonin in PCOS. MATERIALS AND METHODS: Electronic databases including PubMed/MEDLINE, Web of Science, Scopus, and Reaxys were searched from their inception to October 2018 using the keywords “Melatonin” AND “Polycystic ovary syndrome” OR “PCOS.” RESULTS: Based on the data included in our review, it was found that the administration of melatonin can improve the oocyte and embryo quality in PCOS patients. It may also have beneficial effects in correcting the hormonal alterations in PCOS patients. CONCLUSION: Since metabolic dysfunction is the major finding contributing to the initiation of PCOS, melatonin can hinder this process via its improving effects on metabolic functions.
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spelling pubmed-69437972020-01-22 The role of melatonin in polycystic ovary syndrome: A review Mojaverrostami, Sina Asghari, Narjes Khamisabadi, Mahsa Heidari Khoei, Heidar Int J Reprod Biomed Review Article BACKGROUND: Polycystic ovary syndrome (PCOS) is a widespread endocrine disorder, affecting approximately 20% of women within reproductive age. It is associated with hyperandrogenism, obesity, menstrual irregularity, and anovulatory infertility. Melatonin is the main pineal gland hormone involved in the regulation of the circadian rhythm. In recent years, it has been observed that a reduction in melatonin levels of follicular fluid exists in PCOS patients. Melatonin receptors in the ovary and intra-follicular fluid adjust sex steroid secretion at different phases of ovarian follicular maturation. Moreover, melatonin is a strong antioxidant and an effective free radical scavenger, which protects ovarian follicles during follicular maturation. OBJECTIVE: In this paper, we conducted a literature review and the summary of the current research on the role of melatonin in PCOS. MATERIALS AND METHODS: Electronic databases including PubMed/MEDLINE, Web of Science, Scopus, and Reaxys were searched from their inception to October 2018 using the keywords “Melatonin” AND “Polycystic ovary syndrome” OR “PCOS.” RESULTS: Based on the data included in our review, it was found that the administration of melatonin can improve the oocyte and embryo quality in PCOS patients. It may also have beneficial effects in correcting the hormonal alterations in PCOS patients. CONCLUSION: Since metabolic dysfunction is the major finding contributing to the initiation of PCOS, melatonin can hinder this process via its improving effects on metabolic functions. Knowledge E 2019-12-30 /pmc/articles/PMC6943797/ /pubmed/31970309 http://dx.doi.org/10.18502/ijrm.v17i12.5789 Text en Copyright © 2019 Mojaverrostami et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Review Article
Mojaverrostami, Sina
Asghari, Narjes
Khamisabadi, Mahsa
Heidari Khoei, Heidar
The role of melatonin in polycystic ovary syndrome: A review
title The role of melatonin in polycystic ovary syndrome: A review
title_full The role of melatonin in polycystic ovary syndrome: A review
title_fullStr The role of melatonin in polycystic ovary syndrome: A review
title_full_unstemmed The role of melatonin in polycystic ovary syndrome: A review
title_short The role of melatonin in polycystic ovary syndrome: A review
title_sort role of melatonin in polycystic ovary syndrome: a review
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6943797/
https://www.ncbi.nlm.nih.gov/pubmed/31970309
http://dx.doi.org/10.18502/ijrm.v17i12.5789
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