An Autophagy Inducing Triterpene Saponin Derived from Aster koraiensis

Autophagy is an important self-degradative mechanism that plays a key role in treating neurodegeneration diseases. This research aimed at discovering bioactive compounds from Aster koraiensis. A new triterpene saponin, astersaponin I (1), was isolated from the EtOH extract of A. koraiensis. The stru...

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Autores principales: Kwon, Jaeyoung, Ko, Keebeom, Zhang, Lijun, Zhao, Dong, Yang, Hyun Ok, Kwon, Hak Cheol
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6943805/
https://www.ncbi.nlm.nih.gov/pubmed/31817934
http://dx.doi.org/10.3390/molecules24244489
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author Kwon, Jaeyoung
Ko, Keebeom
Zhang, Lijun
Zhao, Dong
Yang, Hyun Ok
Kwon, Hak Cheol
author_facet Kwon, Jaeyoung
Ko, Keebeom
Zhang, Lijun
Zhao, Dong
Yang, Hyun Ok
Kwon, Hak Cheol
author_sort Kwon, Jaeyoung
collection PubMed
description Autophagy is an important self-degradative mechanism that plays a key role in treating neurodegeneration diseases. This research aimed at discovering bioactive compounds from Aster koraiensis. A new triterpene saponin, astersaponin I (1), was isolated from the EtOH extract of A. koraiensis. The structure of 1 was characterized by spectroscopic methods, ECD calculation, and acid hydrolysis. The biochemical analysis showed that compound 1 significantly increased the expression of microtubule-associated protein 1A/1B light chain 3B (LC3-II) expression in SH-SY5Y cells, which indicates the induction of autophagy. Thus, further study may be needed to clarify whether compound 1 exerts beneficial effects on neurodegeneration diseases like Parkinson’s disease through autophagy induction.
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spelling pubmed-69438052020-01-10 An Autophagy Inducing Triterpene Saponin Derived from Aster koraiensis Kwon, Jaeyoung Ko, Keebeom Zhang, Lijun Zhao, Dong Yang, Hyun Ok Kwon, Hak Cheol Molecules Communication Autophagy is an important self-degradative mechanism that plays a key role in treating neurodegeneration diseases. This research aimed at discovering bioactive compounds from Aster koraiensis. A new triterpene saponin, astersaponin I (1), was isolated from the EtOH extract of A. koraiensis. The structure of 1 was characterized by spectroscopic methods, ECD calculation, and acid hydrolysis. The biochemical analysis showed that compound 1 significantly increased the expression of microtubule-associated protein 1A/1B light chain 3B (LC3-II) expression in SH-SY5Y cells, which indicates the induction of autophagy. Thus, further study may be needed to clarify whether compound 1 exerts beneficial effects on neurodegeneration diseases like Parkinson’s disease through autophagy induction. MDPI 2019-12-07 /pmc/articles/PMC6943805/ /pubmed/31817934 http://dx.doi.org/10.3390/molecules24244489 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Kwon, Jaeyoung
Ko, Keebeom
Zhang, Lijun
Zhao, Dong
Yang, Hyun Ok
Kwon, Hak Cheol
An Autophagy Inducing Triterpene Saponin Derived from Aster koraiensis
title An Autophagy Inducing Triterpene Saponin Derived from Aster koraiensis
title_full An Autophagy Inducing Triterpene Saponin Derived from Aster koraiensis
title_fullStr An Autophagy Inducing Triterpene Saponin Derived from Aster koraiensis
title_full_unstemmed An Autophagy Inducing Triterpene Saponin Derived from Aster koraiensis
title_short An Autophagy Inducing Triterpene Saponin Derived from Aster koraiensis
title_sort autophagy inducing triterpene saponin derived from aster koraiensis
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6943805/
https://www.ncbi.nlm.nih.gov/pubmed/31817934
http://dx.doi.org/10.3390/molecules24244489
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