Biosynthetic engineering of the antifungal, anti-MRSA auroramycin

Using an established CRISPR-Cas mediated genome editing technique for streptomycetes, we explored the combinatorial biosynthesis potential of the auroramycin biosynthetic gene cluster in Streptomyces roseosporous. Auroramycin is a potent anti-MRSA polyene macrolactam. In addition, auroramycin has an...

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Detalles Bibliográficos
Autores principales: Yeo, Wan Lin, Heng, Elena, Tan, Lee Ling, Lim, Yi Wee, Ching, Kuan Chieh, Tsai, De-Juin, Jhang, Yi Wun, Lauderdale, Tsai-Ling, Shia, Kak-Shan, Zhao, Huimin, Ang, Ee Lui, Zhang, Mingzi M., Lim, Yee Hwee, Wong, Fong T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6943886/
https://www.ncbi.nlm.nih.gov/pubmed/31906943
http://dx.doi.org/10.1186/s12934-019-1274-y

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