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Association between serotonin 2A receptor (HTR2A) genetic variations and risk of hypertension in a community-based cohort study

BACKGROUND: Hypertension is one of the risk factors for obesity-related cardiovascular diseases. We investigated whether genetic variations in serotonin 2A receptor (HTR2A) were associated with hypertension. METHODS: We carried out a cross-sectional study in cohorts A (Ansan-Ansung cohort, N = 6039)...

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Autores principales: Choi, Jung Ran, Jeon, Minhee, Koh, Sang Baek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6943889/
https://www.ncbi.nlm.nih.gov/pubmed/31906879
http://dx.doi.org/10.1186/s12881-019-0927-3
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author Choi, Jung Ran
Jeon, Minhee
Koh, Sang Baek
author_facet Choi, Jung Ran
Jeon, Minhee
Koh, Sang Baek
author_sort Choi, Jung Ran
collection PubMed
description BACKGROUND: Hypertension is one of the risk factors for obesity-related cardiovascular diseases. We investigated whether genetic variations in serotonin 2A receptor (HTR2A) were associated with hypertension. METHODS: We carried out a cross-sectional study in cohorts A (Ansan-Ansung cohort, N = 6039) and B (Wonju-Pyengchang cohort, N = 7524). Several genetic variants in HTR2A including rs7330636, rs9590999, rs2183057, and rs4942595 were selected and genotyped. RESULTS: In hypertensive participants in cohort A, the baseline systolic blood pressure and body mass index were 141.80 ± 17.20 mg/dL and 24.48 ± 4.75 kg/m(2), respectively, which were higher than in those without hypertension (p < 0.001). rs4942595TC genotype was associated with hypertension in cohort A (OR = 0.739), after adjusting for variables. Subjects with rs4942578AA genotype had a decreased risk of hypertension after adjusting for clinical factor (OR = 0.735) in cohort B, and an elevated risk of hypertension in cohort A (OR = 1.562). The logistic regression analysis showed that participants with rs4941573TC genotype were 1.327 times more likely to have a higher blood pressure than those with TT genotype (95% CI 1.101–1.599) in cohort B. Whereas, the OR for developing hypertension in subjects with rs17069883CC genotype compared to those with AA genotype was 1.447 (95% CI 1.018–2.056; p for trend = 0.040) in cohort A. CONCLUSIONS: HTR2A genetic variations were associated with hypertension risk in our study.
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spelling pubmed-69438892020-01-07 Association between serotonin 2A receptor (HTR2A) genetic variations and risk of hypertension in a community-based cohort study Choi, Jung Ran Jeon, Minhee Koh, Sang Baek BMC Med Genet Research Article BACKGROUND: Hypertension is one of the risk factors for obesity-related cardiovascular diseases. We investigated whether genetic variations in serotonin 2A receptor (HTR2A) were associated with hypertension. METHODS: We carried out a cross-sectional study in cohorts A (Ansan-Ansung cohort, N = 6039) and B (Wonju-Pyengchang cohort, N = 7524). Several genetic variants in HTR2A including rs7330636, rs9590999, rs2183057, and rs4942595 were selected and genotyped. RESULTS: In hypertensive participants in cohort A, the baseline systolic blood pressure and body mass index were 141.80 ± 17.20 mg/dL and 24.48 ± 4.75 kg/m(2), respectively, which were higher than in those without hypertension (p < 0.001). rs4942595TC genotype was associated with hypertension in cohort A (OR = 0.739), after adjusting for variables. Subjects with rs4942578AA genotype had a decreased risk of hypertension after adjusting for clinical factor (OR = 0.735) in cohort B, and an elevated risk of hypertension in cohort A (OR = 1.562). The logistic regression analysis showed that participants with rs4941573TC genotype were 1.327 times more likely to have a higher blood pressure than those with TT genotype (95% CI 1.101–1.599) in cohort B. Whereas, the OR for developing hypertension in subjects with rs17069883CC genotype compared to those with AA genotype was 1.447 (95% CI 1.018–2.056; p for trend = 0.040) in cohort A. CONCLUSIONS: HTR2A genetic variations were associated with hypertension risk in our study. BioMed Central 2020-01-06 /pmc/articles/PMC6943889/ /pubmed/31906879 http://dx.doi.org/10.1186/s12881-019-0927-3 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Choi, Jung Ran
Jeon, Minhee
Koh, Sang Baek
Association between serotonin 2A receptor (HTR2A) genetic variations and risk of hypertension in a community-based cohort study
title Association between serotonin 2A receptor (HTR2A) genetic variations and risk of hypertension in a community-based cohort study
title_full Association between serotonin 2A receptor (HTR2A) genetic variations and risk of hypertension in a community-based cohort study
title_fullStr Association between serotonin 2A receptor (HTR2A) genetic variations and risk of hypertension in a community-based cohort study
title_full_unstemmed Association between serotonin 2A receptor (HTR2A) genetic variations and risk of hypertension in a community-based cohort study
title_short Association between serotonin 2A receptor (HTR2A) genetic variations and risk of hypertension in a community-based cohort study
title_sort association between serotonin 2a receptor (htr2a) genetic variations and risk of hypertension in a community-based cohort study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6943889/
https://www.ncbi.nlm.nih.gov/pubmed/31906879
http://dx.doi.org/10.1186/s12881-019-0927-3
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