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Dual kidney transplantation offers a safe and effective way to use kidneys from deceased donors older than 70 years

PURPOSE: Dual kidney transplantation (DKT) offers a way to extend the use of kidneys from expanded criteria donors (ECDs). Here, we compared the outcomes of DKT with those of single kidney transplantation from standard criteria donors (SCDs) and ECDs. METHODS: In 2014, we began performing DKT using...

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Autores principales: Lee, Kyo Won, Park, Jae Berm, Cha, So Ra, Lee, Seo Hee, Chung, Young Jae, Yoo, Heejin, Kim, Kyunga, Kim, Sung Joo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6943896/
https://www.ncbi.nlm.nih.gov/pubmed/31902366
http://dx.doi.org/10.1186/s12882-019-1664-8
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author Lee, Kyo Won
Park, Jae Berm
Cha, So Ra
Lee, Seo Hee
Chung, Young Jae
Yoo, Heejin
Kim, Kyunga
Kim, Sung Joo
author_facet Lee, Kyo Won
Park, Jae Berm
Cha, So Ra
Lee, Seo Hee
Chung, Young Jae
Yoo, Heejin
Kim, Kyunga
Kim, Sung Joo
author_sort Lee, Kyo Won
collection PubMed
description PURPOSE: Dual kidney transplantation (DKT) offers a way to extend the use of kidneys from expanded criteria donors (ECDs). Here, we compared the outcomes of DKT with those of single kidney transplantation from standard criteria donors (SCDs) and ECDs. METHODS: In 2014, we began performing DKT using both kidneys from deceased donors greater than 70 years of age with one of two risk factors: serum creatinine (sCr) level over 3.0 mg/dl or eGFR under 30 ml/min. By 2017, we had performed 15 DKTs. We compared the outcomes of the 15 DKT recipients with those of 124 patients who received a kidney from an SCD and 80 patients who received a kidney from an ECD. RESULTS: Compared with ECDs and SCDs, DKT donors were older, had a higher diabetes burden, and a higher sCr level (p < 0.01, < 0.01, and 0.03, respectively). DKT recipients were also older and had a higher diabetes burden than recipients of kidneys from ECDs and SCDs (p < 0.01, both). DKT recipients had a lower nadir sCr and shorter duration to nadir sCr than single ECD KT recipients (p < 0.01and 0.04, respectively). CONCLUSIONS: The survival rates of DKT grafts were compatible with those of single KT grafts. Therefore, DKT may be considered a suitable an option to expand the donor pool.
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spelling pubmed-69438962020-01-07 Dual kidney transplantation offers a safe and effective way to use kidneys from deceased donors older than 70 years Lee, Kyo Won Park, Jae Berm Cha, So Ra Lee, Seo Hee Chung, Young Jae Yoo, Heejin Kim, Kyunga Kim, Sung Joo BMC Nephrol Research Article PURPOSE: Dual kidney transplantation (DKT) offers a way to extend the use of kidneys from expanded criteria donors (ECDs). Here, we compared the outcomes of DKT with those of single kidney transplantation from standard criteria donors (SCDs) and ECDs. METHODS: In 2014, we began performing DKT using both kidneys from deceased donors greater than 70 years of age with one of two risk factors: serum creatinine (sCr) level over 3.0 mg/dl or eGFR under 30 ml/min. By 2017, we had performed 15 DKTs. We compared the outcomes of the 15 DKT recipients with those of 124 patients who received a kidney from an SCD and 80 patients who received a kidney from an ECD. RESULTS: Compared with ECDs and SCDs, DKT donors were older, had a higher diabetes burden, and a higher sCr level (p < 0.01, < 0.01, and 0.03, respectively). DKT recipients were also older and had a higher diabetes burden than recipients of kidneys from ECDs and SCDs (p < 0.01, both). DKT recipients had a lower nadir sCr and shorter duration to nadir sCr than single ECD KT recipients (p < 0.01and 0.04, respectively). CONCLUSIONS: The survival rates of DKT grafts were compatible with those of single KT grafts. Therefore, DKT may be considered a suitable an option to expand the donor pool. BioMed Central 2020-01-06 /pmc/articles/PMC6943896/ /pubmed/31902366 http://dx.doi.org/10.1186/s12882-019-1664-8 Text en © The Author(s). 2020 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Lee, Kyo Won
Park, Jae Berm
Cha, So Ra
Lee, Seo Hee
Chung, Young Jae
Yoo, Heejin
Kim, Kyunga
Kim, Sung Joo
Dual kidney transplantation offers a safe and effective way to use kidneys from deceased donors older than 70 years
title Dual kidney transplantation offers a safe and effective way to use kidneys from deceased donors older than 70 years
title_full Dual kidney transplantation offers a safe and effective way to use kidneys from deceased donors older than 70 years
title_fullStr Dual kidney transplantation offers a safe and effective way to use kidneys from deceased donors older than 70 years
title_full_unstemmed Dual kidney transplantation offers a safe and effective way to use kidneys from deceased donors older than 70 years
title_short Dual kidney transplantation offers a safe and effective way to use kidneys from deceased donors older than 70 years
title_sort dual kidney transplantation offers a safe and effective way to use kidneys from deceased donors older than 70 years
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6943896/
https://www.ncbi.nlm.nih.gov/pubmed/31902366
http://dx.doi.org/10.1186/s12882-019-1664-8
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