Cargando…
Dual kidney transplantation offers a safe and effective way to use kidneys from deceased donors older than 70 years
PURPOSE: Dual kidney transplantation (DKT) offers a way to extend the use of kidneys from expanded criteria donors (ECDs). Here, we compared the outcomes of DKT with those of single kidney transplantation from standard criteria donors (SCDs) and ECDs. METHODS: In 2014, we began performing DKT using...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6943896/ https://www.ncbi.nlm.nih.gov/pubmed/31902366 http://dx.doi.org/10.1186/s12882-019-1664-8 |
_version_ | 1783484970874961920 |
---|---|
author | Lee, Kyo Won Park, Jae Berm Cha, So Ra Lee, Seo Hee Chung, Young Jae Yoo, Heejin Kim, Kyunga Kim, Sung Joo |
author_facet | Lee, Kyo Won Park, Jae Berm Cha, So Ra Lee, Seo Hee Chung, Young Jae Yoo, Heejin Kim, Kyunga Kim, Sung Joo |
author_sort | Lee, Kyo Won |
collection | PubMed |
description | PURPOSE: Dual kidney transplantation (DKT) offers a way to extend the use of kidneys from expanded criteria donors (ECDs). Here, we compared the outcomes of DKT with those of single kidney transplantation from standard criteria donors (SCDs) and ECDs. METHODS: In 2014, we began performing DKT using both kidneys from deceased donors greater than 70 years of age with one of two risk factors: serum creatinine (sCr) level over 3.0 mg/dl or eGFR under 30 ml/min. By 2017, we had performed 15 DKTs. We compared the outcomes of the 15 DKT recipients with those of 124 patients who received a kidney from an SCD and 80 patients who received a kidney from an ECD. RESULTS: Compared with ECDs and SCDs, DKT donors were older, had a higher diabetes burden, and a higher sCr level (p < 0.01, < 0.01, and 0.03, respectively). DKT recipients were also older and had a higher diabetes burden than recipients of kidneys from ECDs and SCDs (p < 0.01, both). DKT recipients had a lower nadir sCr and shorter duration to nadir sCr than single ECD KT recipients (p < 0.01and 0.04, respectively). CONCLUSIONS: The survival rates of DKT grafts were compatible with those of single KT grafts. Therefore, DKT may be considered a suitable an option to expand the donor pool. |
format | Online Article Text |
id | pubmed-6943896 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-69438962020-01-07 Dual kidney transplantation offers a safe and effective way to use kidneys from deceased donors older than 70 years Lee, Kyo Won Park, Jae Berm Cha, So Ra Lee, Seo Hee Chung, Young Jae Yoo, Heejin Kim, Kyunga Kim, Sung Joo BMC Nephrol Research Article PURPOSE: Dual kidney transplantation (DKT) offers a way to extend the use of kidneys from expanded criteria donors (ECDs). Here, we compared the outcomes of DKT with those of single kidney transplantation from standard criteria donors (SCDs) and ECDs. METHODS: In 2014, we began performing DKT using both kidneys from deceased donors greater than 70 years of age with one of two risk factors: serum creatinine (sCr) level over 3.0 mg/dl or eGFR under 30 ml/min. By 2017, we had performed 15 DKTs. We compared the outcomes of the 15 DKT recipients with those of 124 patients who received a kidney from an SCD and 80 patients who received a kidney from an ECD. RESULTS: Compared with ECDs and SCDs, DKT donors were older, had a higher diabetes burden, and a higher sCr level (p < 0.01, < 0.01, and 0.03, respectively). DKT recipients were also older and had a higher diabetes burden than recipients of kidneys from ECDs and SCDs (p < 0.01, both). DKT recipients had a lower nadir sCr and shorter duration to nadir sCr than single ECD KT recipients (p < 0.01and 0.04, respectively). CONCLUSIONS: The survival rates of DKT grafts were compatible with those of single KT grafts. Therefore, DKT may be considered a suitable an option to expand the donor pool. BioMed Central 2020-01-06 /pmc/articles/PMC6943896/ /pubmed/31902366 http://dx.doi.org/10.1186/s12882-019-1664-8 Text en © The Author(s). 2020 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Lee, Kyo Won Park, Jae Berm Cha, So Ra Lee, Seo Hee Chung, Young Jae Yoo, Heejin Kim, Kyunga Kim, Sung Joo Dual kidney transplantation offers a safe and effective way to use kidneys from deceased donors older than 70 years |
title | Dual kidney transplantation offers a safe and effective way to use kidneys from deceased donors older than 70 years |
title_full | Dual kidney transplantation offers a safe and effective way to use kidneys from deceased donors older than 70 years |
title_fullStr | Dual kidney transplantation offers a safe and effective way to use kidneys from deceased donors older than 70 years |
title_full_unstemmed | Dual kidney transplantation offers a safe and effective way to use kidneys from deceased donors older than 70 years |
title_short | Dual kidney transplantation offers a safe and effective way to use kidneys from deceased donors older than 70 years |
title_sort | dual kidney transplantation offers a safe and effective way to use kidneys from deceased donors older than 70 years |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6943896/ https://www.ncbi.nlm.nih.gov/pubmed/31902366 http://dx.doi.org/10.1186/s12882-019-1664-8 |
work_keys_str_mv | AT leekyowon dualkidneytransplantationoffersasafeandeffectivewaytousekidneysfromdeceaseddonorsolderthan70years AT parkjaeberm dualkidneytransplantationoffersasafeandeffectivewaytousekidneysfromdeceaseddonorsolderthan70years AT chasora dualkidneytransplantationoffersasafeandeffectivewaytousekidneysfromdeceaseddonorsolderthan70years AT leeseohee dualkidneytransplantationoffersasafeandeffectivewaytousekidneysfromdeceaseddonorsolderthan70years AT chungyoungjae dualkidneytransplantationoffersasafeandeffectivewaytousekidneysfromdeceaseddonorsolderthan70years AT yooheejin dualkidneytransplantationoffersasafeandeffectivewaytousekidneysfromdeceaseddonorsolderthan70years AT kimkyunga dualkidneytransplantationoffersasafeandeffectivewaytousekidneysfromdeceaseddonorsolderthan70years AT kimsungjoo dualkidneytransplantationoffersasafeandeffectivewaytousekidneysfromdeceaseddonorsolderthan70years |