Cargando…
Hydroxyurea-induced Tongue Hypermelanosis and Transverse Melanonychia
Hydroxyurea (HU) is a commonly used medication for myeloproliferative neoplasm (MPN) and is usually well tolerated. Cutaneous toxicity of HU is well known and can be seen in several manifestations. We report a case of a man with MPL gene mutation associated with essential thrombocytosis, who had a r...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cureus
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6944177/ https://www.ncbi.nlm.nih.gov/pubmed/31938603 http://dx.doi.org/10.7759/cureus.6311 |
Sumario: | Hydroxyurea (HU) is a commonly used medication for myeloproliferative neoplasm (MPN) and is usually well tolerated. Cutaneous toxicity of HU is well known and can be seen in several manifestations. We report a case of a man with MPL gene mutation associated with essential thrombocytosis, who had a rare mucocutaneous toxicity with diffuse tongue, skin and nail discoloration. Mucocutaneous toxicity is usually a benign condition and self-resolves after discontinuation of the medication. It can lead to patient anxiety and medication discontinuation. The mechanism for development of HU-induced mucocutaneous hyperpigmentation is poorly understood. |
---|