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Case Report: Acute hemorrhagic edema of infancy (Seidlmayer purpura) – a dramatic presentation for a benign disease

We present a case of an 11-month-old girl who was referred to our unit for an erythematous rash that appeared on the face and extremities. Personal and family history was not relevant. Laboratory tests were normal. During recovery, diameter and colour intensity of the cutaneous lesions increased, bu...

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Autores principales: Carboni, Elena, Scavone, Maria, Stefanelli, Ettore, Talarico, Valentina, Zampogna, Stefania, Galati, Maria Concetta, Raiola, Giuseppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000 Research Limited 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6944248/
https://www.ncbi.nlm.nih.gov/pubmed/31942241
http://dx.doi.org/10.12688/f1000research.20645.1
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author Carboni, Elena
Scavone, Maria
Stefanelli, Ettore
Talarico, Valentina
Zampogna, Stefania
Galati, Maria Concetta
Raiola, Giuseppe
author_facet Carboni, Elena
Scavone, Maria
Stefanelli, Ettore
Talarico, Valentina
Zampogna, Stefania
Galati, Maria Concetta
Raiola, Giuseppe
author_sort Carboni, Elena
collection PubMed
description We present a case of an 11-month-old girl who was referred to our unit for an erythematous rash that appeared on the face and extremities. Personal and family history was not relevant. Laboratory tests were normal. During recovery, diameter and colour intensity of the cutaneous lesions increased, but after some weeks, lesions had a self-limited resolution without any treatment. Based on clinical and laboratory findings, a diagnosis of acute hemorrhagic edema of infancy (AHEI) was made.  AHEI is a rare cutaneous leukocytoclastic vasculitis that usually affects children aged between 4 and 24 months. Etiology is unknown but almost of 75% of cases are preceded by infectious episodes, vaccinations or use of medications. In contrast to the dramatic cutaneous eruption, clinical conditions are usually optimal. Classically, AHEI is characterized by a triad of symptoms: fever, edema and purpura. Skin lesions are erythematous, annular, medallion-like, purpuric plaques that have a rapid onset and appear on the face and extremities, sparing trunk and mucosal membranes. Initially interpreted as a variant of Henoch-Schönlein purpura, now it is considered a distinct disease. In the majority of cases the disease is benign and self-limited without a visceral involvement, so a conservative approach is most often chosen.
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spelling pubmed-69442482020-01-14 Case Report: Acute hemorrhagic edema of infancy (Seidlmayer purpura) – a dramatic presentation for a benign disease Carboni, Elena Scavone, Maria Stefanelli, Ettore Talarico, Valentina Zampogna, Stefania Galati, Maria Concetta Raiola, Giuseppe F1000Res Case Report We present a case of an 11-month-old girl who was referred to our unit for an erythematous rash that appeared on the face and extremities. Personal and family history was not relevant. Laboratory tests were normal. During recovery, diameter and colour intensity of the cutaneous lesions increased, but after some weeks, lesions had a self-limited resolution without any treatment. Based on clinical and laboratory findings, a diagnosis of acute hemorrhagic edema of infancy (AHEI) was made.  AHEI is a rare cutaneous leukocytoclastic vasculitis that usually affects children aged between 4 and 24 months. Etiology is unknown but almost of 75% of cases are preceded by infectious episodes, vaccinations or use of medications. In contrast to the dramatic cutaneous eruption, clinical conditions are usually optimal. Classically, AHEI is characterized by a triad of symptoms: fever, edema and purpura. Skin lesions are erythematous, annular, medallion-like, purpuric plaques that have a rapid onset and appear on the face and extremities, sparing trunk and mucosal membranes. Initially interpreted as a variant of Henoch-Schönlein purpura, now it is considered a distinct disease. In the majority of cases the disease is benign and self-limited without a visceral involvement, so a conservative approach is most often chosen. F1000 Research Limited 2019-10-17 /pmc/articles/PMC6944248/ /pubmed/31942241 http://dx.doi.org/10.12688/f1000research.20645.1 Text en Copyright: © 2019 Carboni E et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Carboni, Elena
Scavone, Maria
Stefanelli, Ettore
Talarico, Valentina
Zampogna, Stefania
Galati, Maria Concetta
Raiola, Giuseppe
Case Report: Acute hemorrhagic edema of infancy (Seidlmayer purpura) – a dramatic presentation for a benign disease
title Case Report: Acute hemorrhagic edema of infancy (Seidlmayer purpura) – a dramatic presentation for a benign disease
title_full Case Report: Acute hemorrhagic edema of infancy (Seidlmayer purpura) – a dramatic presentation for a benign disease
title_fullStr Case Report: Acute hemorrhagic edema of infancy (Seidlmayer purpura) – a dramatic presentation for a benign disease
title_full_unstemmed Case Report: Acute hemorrhagic edema of infancy (Seidlmayer purpura) – a dramatic presentation for a benign disease
title_short Case Report: Acute hemorrhagic edema of infancy (Seidlmayer purpura) – a dramatic presentation for a benign disease
title_sort case report: acute hemorrhagic edema of infancy (seidlmayer purpura) – a dramatic presentation for a benign disease
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6944248/
https://www.ncbi.nlm.nih.gov/pubmed/31942241
http://dx.doi.org/10.12688/f1000research.20645.1
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