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c-Jun overexpression in CAR T cells induces exhaustion resistance

CAR T cells mediate antitumor effects in a small subset of cancer patients(1–3), but dysfunction due to T cell exhaustion is an important barrier to progress(4–6). To investigate the biology of exhaustion in human T cells expressing CAR receptors, we used a model system employing a tonically signali...

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Detalles Bibliográficos
Autores principales:	Lynn, Rachel C., Weber, Evan W., Sotillo, Elena, Gennert, David, Xu, Peng, Good, Zinaida, Anbunathan, Hima, Lattin, John, Jones, Robert, Tieu, Victor, Nagaraja, Surya, Granja, Jeffrey, DeBourcy, Charles, Majzner, Robbie, Satpathy, Ansuman T., Quake, Stephen R., Monje, Michelle, Chang, Howard, Mackall, Crystal L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6944329/ https://www.ncbi.nlm.nih.gov/pubmed/31802004 http://dx.doi.org/10.1038/s41586-019-1805-z

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