Cargando…

CD4 rate of increase is preferred to CD4 threshold for predicting outcomes among virologically suppressed HIV-infected adults on antiretroviral therapy

OBJECTIVES: Immune non-responders (INR) have poor CD4 recovery and are associated with increased risk of serious events despite antiretroviral therapy (ART). A clinically relevant definition for INR is lacking. METHODS: We conducted a retrospective analysis of three large cohorts: Infectious Disease...

Descripción completa

Detalles Bibliográficos
Autores principales:	Aldrete, Sol, Jang, Jeong Hoon, Easley, Kirk A., Okulicz, Jason, Dai, Tian, Chen, Yi No, Pino, Maria, Agan, Brian K., Maves, Ryan C., Paiardini, Mirko, Marconi, Vincent C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6944336/ https://www.ncbi.nlm.nih.gov/pubmed/31905222 http://dx.doi.org/10.1371/journal.pone.0227124

Ejemplares similares

Increased homeostatic cytokines and stability of HIV-infected memory CD4 T-cells identify individuals with suboptimal CD4 T-cell recovery on-ART
por: Pino, Maria, et al.
Publicado: (2021)

Cumulative Viral Load and Virologic Decay Patterns after Antiretroviral Therapy in HIV-Infected Subjects Influence CD4 Recovery and AIDS
por: Marconi, Vincent C., et al.
Publicado: (2011)

Delayed-type hypersensitivity (DTH) test anergy does not impact CD4 reconstitution or normalization of DTH responses during antiretroviral therapy
por: Minidis, Natascha M, et al.
Publicado: (2014)

The loss of CCR6+ and CD161+ CD4+ T cell homeostasis contributes to disease progression in SIV-infected rhesus macaques
por: McGary, Colleen S., et al.
Publicado: (2017)

Association between hepatitis B vaccine antibody response and CD4 reconstitution after initiation of combination antiretroviral therapy in HIV-infected persons
por: Allen, Kahtonna, et al.
Publicado: (2015)

The Impact of Continuous Virologic Suppression on the Development of Non-AIDS Diagnoses
por: Joya, Christie, et al.
Publicado: (2017)

Virological failure and development of new resistance mutations according to CD4 count at combination antiretroviral therapy initiation
por: Jose, S, et al.
Publicado: (2015)

Assessment of metabolic and mitochondrial dynamics in CD4+ and CD8+ T cells in virologically suppressed HIV-positive individuals on combination antiretroviral therapy
por: Masson, Jesse J. R., et al.
Publicado: (2017)

Determinants of Restoration of CD4 and CD8 Cell Counts and Their Ratio in HIV-1–Positive Individuals With Sustained Virological Suppression on Antiretroviral Therapy
por: Gras, Luuk, et al.
Publicado: (2019)

CD4 changes among virologically suppressed patients on antiretroviral therapy: a systematic review and meta-analysis
por: Ford, Nathan, et al.
Publicado: (2015)

CD4 Variability in Malawi: Implications for Use of a CD4 Threshold of 500 Cells/mm(3) Versus Universal Eligibility for Antiretroviral Therapy
por: Schooley, Alan L., et al.
Publicado: (2016)

The role of CD101-expressing CD4 T cells in HIV/SIV pathogenesis and persistence
por: Strongin, Zachary, et al.
Publicado: (2022)

571. In a Well-Characterized Cohort with Universal Access to Care and Medications Racial Disparities in HIV Virologic Outcomes Are No Longer Observed
por: Ganesan, Anuradha, et al.
Publicado: (2018)

Detection of resistance mutations and CD4 slopes in individuals experiencing sustained virological failure
por: Schultze, Anna, et al.
Publicado: (2014)

Utility of CD4 cell counts for early prediction of virological failure during antiretroviral therapy in a resource-limited setting
por: Badri, Motasim, et al.
Publicado: (2008)

Predictors of suboptimal CD4 response among women achieving virologic suppression in a randomized antiretroviral treatment trial, Africa
por: Asmelash, Aida, et al.
Publicado: (2014)

A complex system of chemokines may hold the key to optimal CD4+ T-cell recovery after antiretroviral therapy
por: Sun, Yan V., et al.
Publicado: (2020)

Impact of CD4 and CD8 dynamics and viral rebounds on loss of virological control in HIV controllers
por: Chereau, Fanny, et al.
Publicado: (2017)

CD4(+) and viral load outcomes of antiretroviral therapy switch strategies after virologic failure of combination antiretroviral therapy in perinatally HIV-infected youth in the United States
por: Fairlie, Lee, et al.
Publicado: (2015)

Calculated Globulin Adds Predictive Value to Hepatitis B Vaccine Response in HIV-infected Persons Independently of HIV Viral load and CD4 Cell Count
por: O’Bryan, Thomas, et al.
Publicado: (2017)

CD4 Depletion in SIV-Infected Macaques Results in Macrophage and Microglia Infection with Rapid Turnover of Infected Cells
por: Micci, Luca, et al.
Publicado: (2014)

Combining CD4 recovery and CD4: CD8 ratio restoration as an indicator for evaluating the outcome of continued antiretroviral therapy: an observational cohort study
por: Lee, Shui Shan, et al.
Publicado: (2017)

The Control of the Specificity of CD4 T Cell Responses: Thresholds, Breakpoints, and Ceilings
por: Sant, Andrea J., et al.
Publicado: (2013)

Decreased plasticity of coreceptor use by CD4-independent SIV Envs that emerge in vivo
por: Francella, Nicholas, et al.
Publicado: (2013)

1573. Viral Blips While on Antiretroviral Therapy are Associated with Virologic Failure
por: Fleit, Madeline, et al.
Publicado: (2023)

The CD4:CD8 ratio is associated with IMT progression in HIV-infected patients on antiretroviral treatment
por: Bernal, Enrique, et al.
Publicado: (2014)

Enhanced normalisation of CD4/CD8 ratio with early antiretroviral therapy in primary HIV infection
por: Thornhill, John, et al.
Publicado: (2014)

Gut Homing CD4+ and CD8+ T-Cell Frequencies in HIV Infected Individuals on Antiretroviral Treatment
por: Briceño, Olivia, et al.
Publicado: (2016)

Virological effectiveness and CD4+ T-cell increase over early and late courses in HIV infected patients on antiretroviral therapy: focus on HCV and anchor class received
por: Motta, Davide, et al.
Publicado: (2012)

Immunological predictors of CD4(+ )T cell decline in antiretroviral treatment interruptions
por: Seoane, Elena, et al.
Publicado: (2008)

Elevated CD8 T-cell counts and virological failure in HIV-infected patients after combination antiretroviral therapy
por: Ku, Nam Su, et al.
Publicado: (2016)

The regulated secretory pathway in CD4(+)T cells contributes to HIV-1 transmission at the virological synapse
por: Jolly, Clare, et al.
Publicado: (2011)

Virological footprint of CD4(+) T-cell responses during chronic hepatitis C virus infection
por: Fleming, Vicki M., et al.
Publicado: (2010)

CD4:CD8 Ratio and CD8 Count as Prognostic Markers for Mortality in Human Immunodeficiency Virus–Infected Patients on Antiretroviral Therapy: The Antiretroviral Therapy Cohort Collaboration (ART-CC)
por: Trickey, Adam, et al.
Publicado: (2017)

Comparative Impact of Suppressive Antiretroviral Regimens on the CD4/CD8 T-Cell Ratio: A Cohort Study
por: Masiá, Mar, et al.
Publicado: (2016)

Reconstitution of Intestinal CD4 and Th17 T Cells in Antiretroviral Therapy Suppressed HIV-Infected Subjects: Implication for Residual Immune Activation from the Results of a Clinical Trial
por: d'Ettorre, Gabriella, et al.
Publicado: (2014)

Risk Factors Associated With Chronic Liver Enzyme Elevation in Persons With HIV Without Hepatitis B or C Coinfection in the Combination Antiretroviral Therapy Era
por: Wood, Shannon, et al.
Publicado: (2021)

Long-term CD4+ lymphocyte response following HAART initiation in a U.S. Military prospective cohort
por: Lifson, Alan R, et al.
Publicado: (2011)

Long-Term CD4+ Cell Count in Response to Combination Antiretroviral Therapy
por: Luz, Paula M., et al.
Publicado: (2014)

The investigation of CD4(+)T-cell functions in primary HIV infection with antiretroviral therapy
por: Sun, Yu, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_tt1vjoqmkdsmi0qrvl0j7unft2