Crossover interference and sex-specific genetic maps shape identical by descent sharing in close relatives

Simulations of close relatives and identical by descent (IBD) segments are common in genetic studies, yet most past efforts have utilized sex averaged genetic maps and ignored crossover interference, thus omitting features known to affect the breakpoints of IBD segments. We developed Ped-sim, a meth...

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Detalles Bibliográficos
Autores principales: Caballero, Madison, Seidman, Daniel N., Qiao, Ying, Sannerud, Jens, Dyer, Thomas D., Lehman, Donna M., Curran, Joanne E., Duggirala, Ravindranath, Blangero, John, Carmi, Shai, Williams, Amy L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6944377/
https://www.ncbi.nlm.nih.gov/pubmed/31860654
http://dx.doi.org/10.1371/journal.pgen.1007979

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6944377/
https://www.ncbi.nlm.nih.gov/pubmed/31860654
http://dx.doi.org/10.1371/journal.pgen.1007979

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