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Ecotin, a microbial inhibitor of serine proteases, blocks multiple complement dependent and independent microbicidal activities of human serum

Ecotin is a serine protease inhibitor produced by hundreds of microbial species, including pathogens. Here we show, that ecotin orthologs from Escherichia coli, Yersinia pestis, Pseudomonas aeruginosa and Leishmania major are potent inhibitors of MASP-1 and MASP-2, the two key activator proteases of...

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Detalles Bibliográficos
Autores principales:	Nagy, Zoltán Attila, Szakács, Dávid, Boros, Eszter, Héja, Dávid, Vígh, Eszter, Sándor, Noémi, Józsi, Mihály, Oroszlán, Gábor, Dobó, József, Gál, Péter, Pál, Gábor
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6944378/ https://www.ncbi.nlm.nih.gov/pubmed/31860690 http://dx.doi.org/10.1371/journal.ppat.1008232

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