Systems-level analysis of NalD mutation, a recurrent driver of rapid drug resistance in acute Pseudomonas aeruginosa infection

Pseudomonas aeruginosa, a main cause of human infection, can gain resistance to the antibiotic aztreonam through a mutation in NalD, a transcriptional repressor of cellular efflux. Here we combine computational analysis of clinical isolates, transcriptomics, metabolic modeling and experimental valid...

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Detalles Bibliográficos
Autores principales: Yan, Jinyuan, Estanbouli, Henri, Liao, Chen, Kim, Wook, Monk, Jonathan M., Rahman, Rayees, Kamboj, Mini, Palsson, Bernhard O., Qiu, Weigang, Xavier, Joao B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6944390/
https://www.ncbi.nlm.nih.gov/pubmed/31860667
http://dx.doi.org/10.1371/journal.pcbi.1007562

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