Low-dose metronomic cyclophosphamide complements the actions of an intratumoral C-class CpG TLR9 agonist to potentiate innate immunity and drive potent T cell-mediated anti-tumor responses

The synthetic oligonucleotide SD-101 is a potent and specific agonist for toll-like receptor 9. Intratumoral injection of SD-101 induces significant anti-tumor immunity in preclinical and clinical studies, especially when combined with PD-1 blockade. To build upon this strategy, we studied the enhan...

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Detalles Bibliográficos
Autores principales: Leong, Weng In, Ames, Rachel Y., Haverkamp, Jessica M., Torres, Laura, Kline, Janine, Bans, Ashil, Rocha, Lauren, Gallotta, Marilena, Guiducci, Cristiana, Coffman, Robert L., Janatpour, Mary J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6944447/
https://www.ncbi.nlm.nih.gov/pubmed/31921384
http://dx.doi.org/10.18632/oncotarget.27322

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