Comparison of the Hepatotoxic Potential of Two Treatments for Autosomal-Dominant Polycystic Kidney DiseaseUsing Quantitative Systems Toxicology Modeling

PURPOSE: Autosomal-dominant polycystic kidney disease (ADPKD) is an orphan disease with few current treatment options. The vasopressin V(2) receptor antagonist tolvaptan is approved in multiple countries for the treatment of ADPKD, however its use is associated with clinically significant drug-induc...

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Detalles Bibliográficos
Autores principales: Woodhead, J. L., Pellegrini, L., Shoda, L. K. M., Howell, B. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6944674/
https://www.ncbi.nlm.nih.gov/pubmed/31909447
http://dx.doi.org/10.1007/s11095-019-2726-0

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