The orphan nuclear receptor Nr4a1 mediates perinatal neuroinflammation in a murine model of preterm labor

Prematurity is associated with perinatal neuroinflammation and injury. Screening for genetic modulators in an LPS murine model of preterm birth revealed the upregulation of Nr4a1, an orphan nuclear transcription factor that is normally absent or limited in embryonic brains. Concurrently, Nr4a1 was d...

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Detalles Bibliográficos
Autores principales: Estrada, Sarah M., Thagard, Andrew S., Dehart, Mary J., Damicis, Jennifer R., Dornisch, Elisabeth M., Ippolito, Danielle L., Burd, Irina, Napolitano, Peter G., Ieronimakis, Nicholas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6944691/
https://www.ncbi.nlm.nih.gov/pubmed/31907354
http://dx.doi.org/10.1038/s41419-019-2196-7

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