Linking the low-density lipoprotein receptor-binding segment enables the therapeutic 5-YHEDA peptide to cross the blood-brain barrier and scavenge excess iron and radicals in the brain of senescent mice

INTRODUCTION: Iron accumulates in the brain during aging, which catalyzes radical formation, causing neuronal impairment, and is thus considered a pathogenic factor in Alzheimer's disease (AD). To scavenge excess iron-catalyzed radicals and thereby protect the brain and decrease the incidence o...

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Detalles Bibliográficos
Autores principales: Zou, Zhenyou, Shao, Shengxi, Zou, Ruyi, Qi, Jini, Chen, Liguan, Zhang, Hui, Shen, Qiqiong, Yang, Yue, Ma, Liman, Guo, Ruzeng, Li, Hongwen, Tian, Haibo, Li, Pengxin, Yu, Mingfang, Wang, Lu, Kong, Wenjuan, Li, Caiyu, Yu, Zhenhai, Huang, Yuping, Chen, Li, Shao, Qi, Gao, Xinyan, Chen, Xiaolin, Zhang, Zhengbo, Yan, Jianguo, Shao, Xiaoyun, Pan, Ru, Xu, Lu, Fang, Jing, Zhao, Lei, Huang, Yaohui, Li, Anqi, Zhang, Yuchong, Huang, Wenkao, Tian, Kechun, Hu, Minxin, Xie, Linchao, Wu, Lingbin, Wu, Yu, Luo, Zhen, Xiao, Wenxin, Ma, Shanshan, Wang, Jianan, Huang, Kaixin, He, Siyuan, Yang, Fan, Zhou, Shuni, Jia, Mo, Lu, Hongsheng, Wang, Xinjuan, Tan, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wiley-Blackwell 2019
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6944740/
https://www.ncbi.nlm.nih.gov/pubmed/31921964
http://dx.doi.org/10.1016/j.trci.2019.07.013

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