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Comparing effects of rest with or without a NK1RA on fibrosis and sensorimotor declines induced by a voluntary moderate demand task
OBJECTIVES: Fibrosis is one contributing factor in motor dysfunction and discomfort in patients with overuse musculoskeletal disorders. We pharmacologically targeted the primary receptor for Substance P, neurokinin-1, using a specific antagonist (NK1RA) in a rat model of overuse with the goal of imp...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Society of Musculoskeletal and Neuronal Interactions
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6944794/ https://www.ncbi.nlm.nih.gov/pubmed/31789291 |
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author | Barbe, Mary F. White, Amanda R. Hilliard, Brendan A. Salvadeo, Danielle M. Amin, Mamta Harris, Michele Y. Cruz, Geneva E. Hobson, Lucas Popoff, Steven N. |
author_facet | Barbe, Mary F. White, Amanda R. Hilliard, Brendan A. Salvadeo, Danielle M. Amin, Mamta Harris, Michele Y. Cruz, Geneva E. Hobson, Lucas Popoff, Steven N. |
author_sort | Barbe, Mary F. |
collection | PubMed |
description | OBJECTIVES: Fibrosis is one contributing factor in motor dysfunction and discomfort in patients with overuse musculoskeletal disorders. We pharmacologically targeted the primary receptor for Substance P, neurokinin-1, using a specific antagonist (NK1RA) in a rat model of overuse with the goal of improving tissue fibrosis and discomfort METHODS: Female rats performed a low repetition, high force (LRHF) grasping task for 12 weeks, or performed the task for 12 weeks before being placed on a four week rest break, with or without simultaneous NK1RA treatment. Results were compared to control rats (untreated, or treated 4 weeks with NK1RA or vehicle) RESULTS: Rest improved LRHF-induced declines in grip strength, although rest plus NK1RA treatment (Rest /NK1RA) rescued it. Both treatments improved LRHF-induced increases in muscle TGFβ1 and collagen type 1 levels, forepaw mechanical hypersensitivity (Rest/NK1RA more effectively), macrophage influx into median nerves, and enhanced collagen deposition in forepaw dermis. Only Rest/NK1RA reduced muscle hypercellularity. However, LRHF+4wk Rest /NK1RA rats showed hyposensitivity to noxious hot temperatures CONCLUSIONS: While the NK1RA induced hot temperature hyposensitivity should be taken into consideration if this or related drug were used long-term, the NK1RA more effectively reduced muscle hypercellularity and improved grip strength and forepaw mechanical hypersensitivity. |
format | Online Article Text |
id | pubmed-6944794 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | International Society of Musculoskeletal and Neuronal Interactions |
record_format | MEDLINE/PubMed |
spelling | pubmed-69447942020-01-13 Comparing effects of rest with or without a NK1RA on fibrosis and sensorimotor declines induced by a voluntary moderate demand task Barbe, Mary F. White, Amanda R. Hilliard, Brendan A. Salvadeo, Danielle M. Amin, Mamta Harris, Michele Y. Cruz, Geneva E. Hobson, Lucas Popoff, Steven N. J Musculoskelet Neuronal Interact Original Article OBJECTIVES: Fibrosis is one contributing factor in motor dysfunction and discomfort in patients with overuse musculoskeletal disorders. We pharmacologically targeted the primary receptor for Substance P, neurokinin-1, using a specific antagonist (NK1RA) in a rat model of overuse with the goal of improving tissue fibrosis and discomfort METHODS: Female rats performed a low repetition, high force (LRHF) grasping task for 12 weeks, or performed the task for 12 weeks before being placed on a four week rest break, with or without simultaneous NK1RA treatment. Results were compared to control rats (untreated, or treated 4 weeks with NK1RA or vehicle) RESULTS: Rest improved LRHF-induced declines in grip strength, although rest plus NK1RA treatment (Rest /NK1RA) rescued it. Both treatments improved LRHF-induced increases in muscle TGFβ1 and collagen type 1 levels, forepaw mechanical hypersensitivity (Rest/NK1RA more effectively), macrophage influx into median nerves, and enhanced collagen deposition in forepaw dermis. Only Rest/NK1RA reduced muscle hypercellularity. However, LRHF+4wk Rest /NK1RA rats showed hyposensitivity to noxious hot temperatures CONCLUSIONS: While the NK1RA induced hot temperature hyposensitivity should be taken into consideration if this or related drug were used long-term, the NK1RA more effectively reduced muscle hypercellularity and improved grip strength and forepaw mechanical hypersensitivity. International Society of Musculoskeletal and Neuronal Interactions 2019 /pmc/articles/PMC6944794/ /pubmed/31789291 Text en Copyright: © Journal of Musculoskeletal and Neuronal Interactions http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 4.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Barbe, Mary F. White, Amanda R. Hilliard, Brendan A. Salvadeo, Danielle M. Amin, Mamta Harris, Michele Y. Cruz, Geneva E. Hobson, Lucas Popoff, Steven N. Comparing effects of rest with or without a NK1RA on fibrosis and sensorimotor declines induced by a voluntary moderate demand task |
title | Comparing effects of rest with or without a NK1RA on fibrosis and sensorimotor declines induced by a voluntary moderate demand task |
title_full | Comparing effects of rest with or without a NK1RA on fibrosis and sensorimotor declines induced by a voluntary moderate demand task |
title_fullStr | Comparing effects of rest with or without a NK1RA on fibrosis and sensorimotor declines induced by a voluntary moderate demand task |
title_full_unstemmed | Comparing effects of rest with or without a NK1RA on fibrosis and sensorimotor declines induced by a voluntary moderate demand task |
title_short | Comparing effects of rest with or without a NK1RA on fibrosis and sensorimotor declines induced by a voluntary moderate demand task |
title_sort | comparing effects of rest with or without a nk1ra on fibrosis and sensorimotor declines induced by a voluntary moderate demand task |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6944794/ https://www.ncbi.nlm.nih.gov/pubmed/31789291 |
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