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TRIM21‐mediated proteasomal degradation of SAMHD1 regulates its antiviral activity

SAMHD1 possesses multiple functions, but whether cellular factors regulate SAMHD1 expression or its function remains not well characterized. Here, by investigating why cultured RD and HEK293T cells show different sensitivity to enterovirus 71 (EV71) infection, we demonstrate that SAMHD1 is a restric...

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Detalles Bibliográficos
Autores principales:	Li, Zhaolong, Huan, Chen, Wang, Hong, Liu, Yue, Liu, Xin, Su, Xing, Yu, Jinghua, Zhao, Zhilei, Yu, Xiao‐Fang, Zheng, Baisong, Zhang, Wenyan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2019
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6944907/ https://www.ncbi.nlm.nih.gov/pubmed/31797533 http://dx.doi.org/10.15252/embr.201847528

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