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Safety of Aqueous Extract of Calea ternifolia Used in Mexican Traditional Medicine
There is a trend to use medicinal plants for primary medical care or as dietary supplements; however, the safety of many of these plants has not been studied. The objective of this work was to determine the toxic effect of the aqueous extract of Calea ternifolia (C. zacatechichi), known popularly as...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6944969/ https://www.ncbi.nlm.nih.gov/pubmed/31949470 http://dx.doi.org/10.1155/2019/7478152 |
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author | González-Yáñez, Ma G. E. Rivas-Morales, Catalina Oranday-Cárdenas, María A. Verde-Star, María J. Núñez-González, María A. Sanchez, Eduardo Leos-Rivas, Catalina |
author_facet | González-Yáñez, Ma G. E. Rivas-Morales, Catalina Oranday-Cárdenas, María A. Verde-Star, María J. Núñez-González, María A. Sanchez, Eduardo Leos-Rivas, Catalina |
author_sort | González-Yáñez, Ma G. E. |
collection | PubMed |
description | There is a trend to use medicinal plants for primary medical care or as dietary supplements; however, the safety of many of these plants has not been studied. The objective of this work was to determine the toxic effect of the aqueous extract of Calea ternifolia (C. zacatechichi), known popularly as “dream herb” in vivo and in vitro in order to validate its safety. In vivo, the extract had moderate toxicity on A. salina. In vitro, the extract induced eryptosis of 73% at a concentration of 100 μg·mL(−1) and it inhibited CYP3A by 99% at a concentration of 375 μg/mL. After administering 8.5 mg/kg of C. ternifolia to rats, we found a reduction in platelets and leukocytes and an increase in urea and the liver enzymes alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP). Histological analysis showed spongiform changes in the proximal tubules of renal tissue and a lymphoid infiltrate in liver tissue. This plant is used in the treatment of diabetes, and it is commercialized as a dietary supplement in several countries. Our results show renal and hepatic toxicity; therefore, more profound research on the toxicity of this plant is needed. |
format | Online Article Text |
id | pubmed-6944969 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-69449692020-01-16 Safety of Aqueous Extract of Calea ternifolia Used in Mexican Traditional Medicine González-Yáñez, Ma G. E. Rivas-Morales, Catalina Oranday-Cárdenas, María A. Verde-Star, María J. Núñez-González, María A. Sanchez, Eduardo Leos-Rivas, Catalina Evid Based Complement Alternat Med Research Article There is a trend to use medicinal plants for primary medical care or as dietary supplements; however, the safety of many of these plants has not been studied. The objective of this work was to determine the toxic effect of the aqueous extract of Calea ternifolia (C. zacatechichi), known popularly as “dream herb” in vivo and in vitro in order to validate its safety. In vivo, the extract had moderate toxicity on A. salina. In vitro, the extract induced eryptosis of 73% at a concentration of 100 μg·mL(−1) and it inhibited CYP3A by 99% at a concentration of 375 μg/mL. After administering 8.5 mg/kg of C. ternifolia to rats, we found a reduction in platelets and leukocytes and an increase in urea and the liver enzymes alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP). Histological analysis showed spongiform changes in the proximal tubules of renal tissue and a lymphoid infiltrate in liver tissue. This plant is used in the treatment of diabetes, and it is commercialized as a dietary supplement in several countries. Our results show renal and hepatic toxicity; therefore, more profound research on the toxicity of this plant is needed. Hindawi 2019-12-26 /pmc/articles/PMC6944969/ /pubmed/31949470 http://dx.doi.org/10.1155/2019/7478152 Text en Copyright © 2019 Ma G. E. González-Yáñez et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article González-Yáñez, Ma G. E. Rivas-Morales, Catalina Oranday-Cárdenas, María A. Verde-Star, María J. Núñez-González, María A. Sanchez, Eduardo Leos-Rivas, Catalina Safety of Aqueous Extract of Calea ternifolia Used in Mexican Traditional Medicine |
title | Safety of Aqueous Extract of Calea ternifolia Used in Mexican Traditional Medicine |
title_full | Safety of Aqueous Extract of Calea ternifolia Used in Mexican Traditional Medicine |
title_fullStr | Safety of Aqueous Extract of Calea ternifolia Used in Mexican Traditional Medicine |
title_full_unstemmed | Safety of Aqueous Extract of Calea ternifolia Used in Mexican Traditional Medicine |
title_short | Safety of Aqueous Extract of Calea ternifolia Used in Mexican Traditional Medicine |
title_sort | safety of aqueous extract of calea ternifolia used in mexican traditional medicine |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6944969/ https://www.ncbi.nlm.nih.gov/pubmed/31949470 http://dx.doi.org/10.1155/2019/7478152 |
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