Aβ43‐producing PS1 FAD mutants cause altered substrate interactions and respond to γ‐secretase modulation

Abnormal generation of neurotoxic amyloid‐β peptide (Aβ) 42/43 species due to mutations in the catalytic presenilin 1 (PS1) subunit of γ‐secretase is the major cause of familial Alzheimer's disease (FAD). Deeper mechanistic insight on the generation of Aβ43 is still lacking, and it is unclear w...

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Detalles Bibliográficos
Autores principales: Trambauer, Johannes, Rodríguez Sarmiento, Rosa María, Fukumori, Akio, Feederle, Regina, Baumann, Karlheinz, Steiner, Harald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6945062/
https://www.ncbi.nlm.nih.gov/pubmed/31762188
http://dx.doi.org/10.15252/embr.201947996

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6945062/
https://www.ncbi.nlm.nih.gov/pubmed/31762188
http://dx.doi.org/10.15252/embr.201947996

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