Cargando…

Aβ43‐producing PS1 FAD mutants cause altered substrate interactions and respond to γ‐secretase modulation

Abnormal generation of neurotoxic amyloid‐β peptide (Aβ) 42/43 species due to mutations in the catalytic presenilin 1 (PS1) subunit of γ‐secretase is the major cause of familial Alzheimer's disease (FAD). Deeper mechanistic insight on the generation of Aβ43 is still lacking, and it is unclear w...

Descripción completa

Detalles Bibliográficos
Autores principales:	Trambauer, Johannes, Rodríguez Sarmiento, Rosa María, Fukumori, Akio, Feederle, Regina, Baumann, Karlheinz, Steiner, Harald
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2019
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6945062/ https://www.ncbi.nlm.nih.gov/pubmed/31762188 http://dx.doi.org/10.15252/embr.201947996

Ejemplares similares

Making the final cut: pathogenic amyloid-β peptide generation by γ-secretase
por: Steiner, Harald, et al.
Publicado: (2018)

Modulation of γ-Secretase Activity by a Carborane-Based Flurbiprofen Analogue
por: Saretz, Stefan, et al.
Publicado: (2021)

Generation and deposition of Aβ43 by the virtually inactive presenilin‐1 L435F mutant contradicts the presenilin loss‐of‐function hypothesis of Alzheimer's disease
por: Kretner, Benedikt, et al.
Publicado: (2016)

Substrate docking to γ-secretase allows access of γ-secretase modulators to an allosteric site
por: Uemura, Kengo, et al.
Publicado: (2010)

Amyloid-PET predicts inhibition of de novo plaque formation upon chronic γ-secretase modulator treatment
por: Brendel, M, et al.
Publicado: (2015)

Mechanisms of γ-Secretase Activation and Substrate Processing
por: Bhattarai, Apurba, et al.
Publicado: (2020)

Proteomic Profiling of γ-Secretase Substrates and Mapping of Substrate Requirements
por: Hemming, Matthew L, et al.
Publicado: (2008)

Substrate ectodomain is critical for substrate preference and inhibition of γ-secretase
por: Funamoto, Satoru, et al.
Publicado: (2013)

Enzyme-substrate hybrid β-sheet controls geometry and water access to the γ-secretase active site
por: Chen, Shu-Yu, et al.
Publicado: (2023)

Cooperation of N- and C-terminal substrate transmembrane domain segments in intramembrane proteolysis by γ-secretase
por: Werner, Nadine T., et al.
Publicado: (2023)

Visualization of PS/γ-Secretase Activity in Living Cells
por: Maesako, Masato, et al.
Publicado: (2020)

Limited Substrate Specificity of PS/γ-Secretase Is Supported by Novel Multiplexed FRET Analysis in Live Cells
por: Houser, Mei C. Q., et al.
Publicado: (2021)

Complex Relationships between Substrate Sequence and Sensitivity to Alterations in γ-Secretase Processivity Induced by γ-Secretase Modulators
por: Jung, Joo In, et al.
Publicado: (2014)

Enzyme–substrate interface targeting by imidazole‐based γ‐secretase modulators activates γ‐secretase and stabilizes its interaction with APP
por: Petit, Dieter, et al.
Publicado: (2022)

Substrate–Enzyme Interactions in Intramembrane Proteolysis: γ-Secretase as the Prototype
por: Liu, Xinyue, et al.
Publicado: (2020)

The Role of Cholesterol in Amyloidogenic Substrate Binding to the γ-Secretase Complex
por: Orzeł, Urszula, et al.
Publicado: (2021)

Active site geometry stabilization of a presenilin homolog by the lipid bilayer promotes intramembrane proteolysis
por: Feilen, Lukas P, et al.
Publicado: (2022)

Inactivation of γ‐secretases leads to accumulation of substrates and non‐Alzheimer neurodegeneration
por: Acx, Hermien, et al.
Publicado: (2017)

Substrate interaction inhibits γ-secretase production of amyloid-β peptides
por: Zhao, Jing, et al.
Publicado: (2020)

GSAP modulates γ-secretase specificity by inducing conformational change in PS1
por: Wong, Eitan, et al.
Publicado: (2019)

An Alzheimer‐associated TREM2 variant occurs at the ADAM cleavage site and affects shedding and phagocytic function
por: Schlepckow, Kai, et al.
Publicado: (2017)

γ‐Secretase cleavage of the Alzheimer risk factor TREM2 is determined by its intrinsic structural dynamics
por: Steiner, Andrea, et al.
Publicado: (2020)

Increased Expression of PS1 Is Sufficient to Elevate the Level and Activity of γ-Secretase In Vivo
por: Li, Tong, et al.
Publicado: (2011)

Presenilin/γ-Secretase and Inflammation
por: Saura, Carlos A.
Publicado: (2010)

γ-Secretase in Alzheimer’s disease
por: Hur, Ji-Yeun
Publicado: (2022)

Specificity of presenilin‐1‐ and presenilin‐2‐dependent γ‐secretases towards substrate processing
por: Stanga, Serena, et al.
Publicado: (2017)

Flexible and Accurate Substrate Processing with Distinct Presenilin/γ-Secretases in Human Cortical Neurons
por: Watanabe, Hirotaka, et al.
Publicado: (2021)

Nanoscale organization of Nicastrin, the substrate receptor of the γ-secretase complex, as independent molecular domains
por: Kedia, Shekhar, et al.
Publicado: (2021)

Interaction of Substrates with γ-Secretase at the Level of Individual Transmembrane Helices—A Methodological Approach
por: Pauli, Theresa M., et al.
Publicado: (2023)

Different transmembrane domains determine the specificity and efficiency of the cleavage activity of the γ-secretase subunit presenilin
por: Schmidt, Fabian C., et al.
Publicado: (2023)

A Novel NIR-FRET Biosensor for Reporting PS/γ-Secretase Activity in Live Cells
por: Houser, Mei CQ, et al.
Publicado: (2020)

γ-Secretase modulators exhibit selectivity for modulation of APP cleavage but inverse γ-secretase modulators do not
por: Lessard, Christian B., et al.
Publicado: (2020)

γ‐Secretase modulators show selectivity for γ‐secretase–mediated amyloid precursor protein intramembrane processing
por: Weber, Tobias A., et al.
Publicado: (2021)

Aph-1 Associates Directly with Full-length and C-terminal Fragments of γ-Secretase Substrates
por: Chen, Allen C., et al.
Publicado: (2010)

Modulation of γ-Secretase Activity by Multiple Enzyme-Substrate Interactions: Implications in Pathogenesis of Alzheimer's Disease
por: Svedružić, Željko M., et al.
Publicado: (2012)

Structure-function relationship of γ-secretase
por: Tomita, Taisuke
Publicado: (2012)

The dynamic conformational landscape of γ-secretase
por: Elad, Nadav, et al.
Publicado: (2015)

Presenilins and γ-Secretase in Membrane Proteostasis
por: Oikawa, Naoto, et al.
Publicado: (2019)

The cytotoxicity of γ-secretase inhibitor I to breast cancer cells is mediated by proteasome inhibition, not by γ-secretase inhibition
por: Han, Jianxun, et al.
Publicado: (2009)

Allosteric Modulation of PS1/γ-Secretase Conformation Correlates with Amyloid β(42/40) Ratio
por: Uemura, Kengo, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_nrjberh67fpovemhjsoe7o9e3q