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Riesgo de enfermedad neumocócica en pacientes ancianos con y sin vacunación previa()

OBJECTIVES: To know the pneumococcal vaccination coverage in patients ≥ 65 years old, as well as the risk of pneumococcal disease according to whether or not they received such vaccination. DESIGN: Cross-sectional study, followed by historical cohort. LOCATION: Urban area. PARTICIPANTS: By systemati...

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Autores principales: Flores-Copete, María, Reolid-Martínez, Ricardo, López-García, Mónica, Alcantud-Lozano, Pilar, Mudarra-Tercero, Esther, Azorín-Ras, Milagros, del Campo-Giménez, María, Ayuso-Raya, M. Candelaria, Escobar-Rabadán, Francisco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6945128/
https://www.ncbi.nlm.nih.gov/pubmed/30391017
http://dx.doi.org/10.1016/j.aprim.2018.07.009
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author Flores-Copete, María
Reolid-Martínez, Ricardo
López-García, Mónica
Alcantud-Lozano, Pilar
Mudarra-Tercero, Esther
Azorín-Ras, Milagros
del Campo-Giménez, María
Ayuso-Raya, M. Candelaria
Escobar-Rabadán, Francisco
author_facet Flores-Copete, María
Reolid-Martínez, Ricardo
López-García, Mónica
Alcantud-Lozano, Pilar
Mudarra-Tercero, Esther
Azorín-Ras, Milagros
del Campo-Giménez, María
Ayuso-Raya, M. Candelaria
Escobar-Rabadán, Francisco
author_sort Flores-Copete, María
collection PubMed
description OBJECTIVES: To know the pneumococcal vaccination coverage in patients ≥ 65 years old, as well as the risk of pneumococcal disease according to whether or not they received such vaccination. DESIGN: Cross-sectional study, followed by historical cohort. LOCATION: Urban area. PARTICIPANTS: By systematic sampling, 2,805 people ≥ 65 years from the city of Albacete were selected. MAIN MEASUREMENTS: Dependent variable: diagnosis of pneumococcal disease and date. Independent variables: age, sex, chronic pathologies, medication, pneumococcal vaccination and date. The computerized medical records were reviewed, from 1-1-2009 to October-December 2015. A descriptive analysis was carried out, the relative risk of the onset of pneumococcal disease according to vaccination has been calculated, and survival analysis has been carried out, with the statistical program SPSS 17.0. RESULTS: Median age 71 years; 57.2% were women; 46% received polysaccharide vaccine (95% CI 44.1-47.8). Only 10 people received conjugated vaccine. Twenty-two people were diagnosed with invasive pneumococcal disease and 153 non-invasive. The relative risk of pneumococcal disease in vaccinated versus unvaccinated, respectively for invasive and non-invasive, was 1.59 (95% CI 0.69-3.68) and 1.84 (95% CI 1.33-2.54). Cox regression showed a higher risk of non-invasive disease for COPD (1.95; 95% CI 1.32-2.89), smoking (1.87; 95% CI 1.28-2.73), corticoid-therapy (1.73; 95% CI 1.08-2.79), polysaccharide vaccination (141.41; 95% CI 5.92-3,378.49) and age (1.11; 95% CI 1.08-1.14), with interaction between these 2 (0.94, 95% CI 0.91-0.98). CONCLUSIONS: There is an increased risk of pneumococcal disease in patients ≥ 65 years vaccinated with polysaccharide, although with a protective effect in vaccinated older.
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spelling pubmed-69451282020-01-09 Riesgo de enfermedad neumocócica en pacientes ancianos con y sin vacunación previa() Flores-Copete, María Reolid-Martínez, Ricardo López-García, Mónica Alcantud-Lozano, Pilar Mudarra-Tercero, Esther Azorín-Ras, Milagros del Campo-Giménez, María Ayuso-Raya, M. Candelaria Escobar-Rabadán, Francisco Aten Primaria Originales OBJECTIVES: To know the pneumococcal vaccination coverage in patients ≥ 65 years old, as well as the risk of pneumococcal disease according to whether or not they received such vaccination. DESIGN: Cross-sectional study, followed by historical cohort. LOCATION: Urban area. PARTICIPANTS: By systematic sampling, 2,805 people ≥ 65 years from the city of Albacete were selected. MAIN MEASUREMENTS: Dependent variable: diagnosis of pneumococcal disease and date. Independent variables: age, sex, chronic pathologies, medication, pneumococcal vaccination and date. The computerized medical records were reviewed, from 1-1-2009 to October-December 2015. A descriptive analysis was carried out, the relative risk of the onset of pneumococcal disease according to vaccination has been calculated, and survival analysis has been carried out, with the statistical program SPSS 17.0. RESULTS: Median age 71 years; 57.2% were women; 46% received polysaccharide vaccine (95% CI 44.1-47.8). Only 10 people received conjugated vaccine. Twenty-two people were diagnosed with invasive pneumococcal disease and 153 non-invasive. The relative risk of pneumococcal disease in vaccinated versus unvaccinated, respectively for invasive and non-invasive, was 1.59 (95% CI 0.69-3.68) and 1.84 (95% CI 1.33-2.54). Cox regression showed a higher risk of non-invasive disease for COPD (1.95; 95% CI 1.32-2.89), smoking (1.87; 95% CI 1.28-2.73), corticoid-therapy (1.73; 95% CI 1.08-2.79), polysaccharide vaccination (141.41; 95% CI 5.92-3,378.49) and age (1.11; 95% CI 1.08-1.14), with interaction between these 2 (0.94, 95% CI 0.91-0.98). CONCLUSIONS: There is an increased risk of pneumococcal disease in patients ≥ 65 years vaccinated with polysaccharide, although with a protective effect in vaccinated older. Elsevier 2019-11 2018-11-01 /pmc/articles/PMC6945128/ /pubmed/30391017 http://dx.doi.org/10.1016/j.aprim.2018.07.009 Text en © 2018 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Originales
Flores-Copete, María
Reolid-Martínez, Ricardo
López-García, Mónica
Alcantud-Lozano, Pilar
Mudarra-Tercero, Esther
Azorín-Ras, Milagros
del Campo-Giménez, María
Ayuso-Raya, M. Candelaria
Escobar-Rabadán, Francisco
Riesgo de enfermedad neumocócica en pacientes ancianos con y sin vacunación previa()
title Riesgo de enfermedad neumocócica en pacientes ancianos con y sin vacunación previa()
title_full Riesgo de enfermedad neumocócica en pacientes ancianos con y sin vacunación previa()
title_fullStr Riesgo de enfermedad neumocócica en pacientes ancianos con y sin vacunación previa()
title_full_unstemmed Riesgo de enfermedad neumocócica en pacientes ancianos con y sin vacunación previa()
title_short Riesgo de enfermedad neumocócica en pacientes ancianos con y sin vacunación previa()
title_sort riesgo de enfermedad neumocócica en pacientes ancianos con y sin vacunación previa()
topic Originales
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6945128/
https://www.ncbi.nlm.nih.gov/pubmed/30391017
http://dx.doi.org/10.1016/j.aprim.2018.07.009
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