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Uptake of prostate-specific membrane antigen-targeted (18)F-DCFPyL in avascular necrosis of the femoral head

In recent years, the emergence of prostate-specific membrane antigen (PSMA)-targeted positron-emission tomography (PET) imaging has brought about a paradigm shift in the way that prostate cancer (PCa) is imaged in many parts of the world. Although PSMA-targeted PET imaging has been demonstrated to b...

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Autores principales: Torga, Gonzalo, Yin, Yafu, Pomper, Martin G., Pienta, Kenneth J., Gorin, Michael A., Rowe, Steven P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6945356/
https://www.ncbi.nlm.nih.gov/pubmed/31933560
http://dx.doi.org/10.4103/wjnm.WJNM_106_18
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author Torga, Gonzalo
Yin, Yafu
Pomper, Martin G.
Pienta, Kenneth J.
Gorin, Michael A.
Rowe, Steven P.
author_facet Torga, Gonzalo
Yin, Yafu
Pomper, Martin G.
Pienta, Kenneth J.
Gorin, Michael A.
Rowe, Steven P.
author_sort Torga, Gonzalo
collection PubMed
description In recent years, the emergence of prostate-specific membrane antigen (PSMA)-targeted positron-emission tomography (PET) imaging has brought about a paradigm shift in the way that prostate cancer (PCa) is imaged in many parts of the world. Although PSMA-targeted PET imaging has been demonstrated to be a highly sensitive and specific imaging modality for the identification of sites of PCa, its clinical utility hinges on the ability of imaging specialists and their clinical colleagues to recognize potential false-positive sources of uptake and to tailor therapy based on that recognition. In this manuscript, we report the case of a 74-year-old male with a history of recurrent PCa who was referred for a restaging PSMA-targeted (18)F-DCFPyL PET/computed tomography (PET/CT). PET images demonstrated low level but focal and definitive uptake in the left femoral head. This uptake corresponded to sclerotic changes on CT whose morphology was most compatible with avascular necrosis without femoral head collapse. In the presented case, the integrated assessment of the CT imaging together with the PET findings was fundamental to avoid misinterpretation of the left femur finding as metastatic disease, which would have ultimately altered the clinical management of the patient.
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spelling pubmed-69453562020-01-13 Uptake of prostate-specific membrane antigen-targeted (18)F-DCFPyL in avascular necrosis of the femoral head Torga, Gonzalo Yin, Yafu Pomper, Martin G. Pienta, Kenneth J. Gorin, Michael A. Rowe, Steven P. World J Nucl Med Case Report In recent years, the emergence of prostate-specific membrane antigen (PSMA)-targeted positron-emission tomography (PET) imaging has brought about a paradigm shift in the way that prostate cancer (PCa) is imaged in many parts of the world. Although PSMA-targeted PET imaging has been demonstrated to be a highly sensitive and specific imaging modality for the identification of sites of PCa, its clinical utility hinges on the ability of imaging specialists and their clinical colleagues to recognize potential false-positive sources of uptake and to tailor therapy based on that recognition. In this manuscript, we report the case of a 74-year-old male with a history of recurrent PCa who was referred for a restaging PSMA-targeted (18)F-DCFPyL PET/computed tomography (PET/CT). PET images demonstrated low level but focal and definitive uptake in the left femoral head. This uptake corresponded to sclerotic changes on CT whose morphology was most compatible with avascular necrosis without femoral head collapse. In the presented case, the integrated assessment of the CT imaging together with the PET findings was fundamental to avoid misinterpretation of the left femur finding as metastatic disease, which would have ultimately altered the clinical management of the patient. Wolters Kluwer - Medknow 2019-12-18 /pmc/articles/PMC6945356/ /pubmed/31933560 http://dx.doi.org/10.4103/wjnm.WJNM_106_18 Text en Copyright: © 2019 World Journal of Nuclear Medicine http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Case Report
Torga, Gonzalo
Yin, Yafu
Pomper, Martin G.
Pienta, Kenneth J.
Gorin, Michael A.
Rowe, Steven P.
Uptake of prostate-specific membrane antigen-targeted (18)F-DCFPyL in avascular necrosis of the femoral head
title Uptake of prostate-specific membrane antigen-targeted (18)F-DCFPyL in avascular necrosis of the femoral head
title_full Uptake of prostate-specific membrane antigen-targeted (18)F-DCFPyL in avascular necrosis of the femoral head
title_fullStr Uptake of prostate-specific membrane antigen-targeted (18)F-DCFPyL in avascular necrosis of the femoral head
title_full_unstemmed Uptake of prostate-specific membrane antigen-targeted (18)F-DCFPyL in avascular necrosis of the femoral head
title_short Uptake of prostate-specific membrane antigen-targeted (18)F-DCFPyL in avascular necrosis of the femoral head
title_sort uptake of prostate-specific membrane antigen-targeted (18)f-dcfpyl in avascular necrosis of the femoral head
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6945356/
https://www.ncbi.nlm.nih.gov/pubmed/31933560
http://dx.doi.org/10.4103/wjnm.WJNM_106_18
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