TSC patient-derived isogenic neural progenitor cells reveal altered early neurodevelopmental phenotypes and rapamycin-induced MNK-eIF4E signaling

BACKGROUND: Tuberous sclerosis complex (TSC) is a neurodevelopmental disorder with frequent occurrence of epilepsy, autism spectrum disorder (ASD), intellectual disability (ID), and tumors in multiple organs. The aberrant activation of mTORC1 in TSC has led to treatment with mTORC1 inhibitor rapamyc...

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Detalles Bibliográficos
Autores principales: Martin, Pauline, Wagh, Vilas, Reis, Surya A., Erdin, Serkan, Beauchamp, Roberta L., Shaikh, Ghalib, Talkowski, Michael, Thiele, Elizabeth, Sheridan, Steven D., Haggarty, Stephen J., Ramesh, Vijaya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6945400/
https://www.ncbi.nlm.nih.gov/pubmed/31921404
http://dx.doi.org/10.1186/s13229-019-0311-3

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