Promoting tau secretion and propagation by hyperactive p300/CBP via autophagy-lysosomal pathway in tauopathy

BACKGROUND: The trans-neuronal propagation of tau has been implicated in the progression of tau-mediated neurodegeneration. There is critical knowledge gap in understanding how tau is released and transmitted, and how that is dysregulated in diseases. Previously, we reported that lysine acetyltransf...

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Detalles Bibliográficos
Autores principales: Chen, Xu, Li, Yaqiao, Wang, Chao, Tang, Yinyan, Mok, Sue-Ann, Tsai, Richard M., Rojas, Julio C., Karydas, Anna, Miller, Bruce L., Boxer, Adam L., Gestwicki, Jason E., Arkin, Michelle, Cuervo, Ana Maria, Gan, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6945522/
https://www.ncbi.nlm.nih.gov/pubmed/31906970
http://dx.doi.org/10.1186/s13024-019-0354-0

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