Cyclase-associated protein 1 is a binding partner of proprotein convertase subtilisin/kexin type-9 and is required for the degradation of low-density lipoprotein receptors by proprotein convertase subtilisin/kexin type-9

AIMS: Proprotein convertase subtilisin/kexin type-9 (PCSK9), a molecular determinant of low-density lipoprotein (LDL) receptor (LDLR) fate, has emerged as a promising therapeutic target for atherosclerotic cardiovascular diseases. However, the precise mechanism by which PCSK9 regulates the internali...

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Detalles Bibliográficos
Autores principales: Jang, Hyun-Duk, Lee, Sang Eun, Yang, Jimin, Lee, Hyun-Chae, Shin, Dasom, Lee, Hwan, Lee, Jaewon, Jin, Sooryeonhwa, Kim, Soungchan, Lee, Seung Ji, You, Jihye, Park, Hyun-Woo, Nam, Ky-Youb, Lee, Sang-Hak, Park, Sahng Wook, Kim, Jin-Soo, Kim, Sang-Yeob, Kwon, Yoo-Wook, Kwak, Soo Heon, Yang, Han-Mo, Kim, Hyo-Soo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Basic Science
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6945527/
https://www.ncbi.nlm.nih.gov/pubmed/31419281
http://dx.doi.org/10.1093/eurheartj/ehz566

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