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Chitotriosidase: a biomarker of activity and severity in patients with sarcoidosis
BACKGROUND: Serum chitotriosidase is a promising biomarker that has shown high specificity and sensitivity in patients with sarcoidosis. The aim of this study was to investigate correlations between serum chitotriosidase, clinical phenotypes, disease localizations and different radiological lung inv...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6945638/ https://www.ncbi.nlm.nih.gov/pubmed/31906975 http://dx.doi.org/10.1186/s12931-019-1263-z |
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author | Bennett, David Cameli, Paolo Lanzarone, Nicola Carobene, Loredana Bianchi, Nicola Fui, Annalisa Rizzi, Luigi Bergantini, Laura Cillis, Giuseppe Miriana, D’ Alessandro Mazzei, Maria Antonietta Refini, Rosa Metella Sestini, Piersante Bargagli, Elena Rottoli, Paola |
author_facet | Bennett, David Cameli, Paolo Lanzarone, Nicola Carobene, Loredana Bianchi, Nicola Fui, Annalisa Rizzi, Luigi Bergantini, Laura Cillis, Giuseppe Miriana, D’ Alessandro Mazzei, Maria Antonietta Refini, Rosa Metella Sestini, Piersante Bargagli, Elena Rottoli, Paola |
author_sort | Bennett, David |
collection | PubMed |
description | BACKGROUND: Serum chitotriosidase is a promising biomarker that has shown high specificity and sensitivity in patients with sarcoidosis. The aim of this study was to investigate correlations between serum chitotriosidase, clinical phenotypes, disease localizations and different radiological lung involvement and to identify clinical features associated with over-expression of chitotriosidase in a large cohort of sarcoidosis patients. METHODS: Chitotriosidase activity was evaluated in a population of 694 consecutive patients (males 39%, age 55.8 ± 12.8 years). Clinical and respiratory functional characteristics, Clinical Outcome Scale (COS) classification, clinical phenotypes proposed by the GenPhenResA project, and radiological assessment, including CT scan, were collected. Serum sampling and clinical and functional assessments at follow-up were also included. RESULTS: Significantly higher chitotriosidase activity was observed in sarcoidosis patients than in healthy controls (p < 0.0001). Evidence of lung fibrosis with reticular abnormalities and traction bronchiectasis at High resolution CT, presence of multiple extrapulmonary sarcoid localizations and increased 24-h urinary excretion of calcium were associated with significantly higher chitotriosidase activity (p < 0.005). Patients with remitted or minimal disease had lower values of chitotriosidase than patients with persistent disease. At follow-up, patients who required an increase in steroid dose showed an increase in its activity. CONCLUSIONS: Chitotriosidase is a reliable biomarker of sarcoidosis. It is increased in patients with sarcoidosis correlating with disease activity, severity and multiorgan dissemination. Steroid therapy tended to reduce chitotriosidase expression, however it responded in cases of disease relapse. |
format | Online Article Text |
id | pubmed-6945638 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-69456382020-01-07 Chitotriosidase: a biomarker of activity and severity in patients with sarcoidosis Bennett, David Cameli, Paolo Lanzarone, Nicola Carobene, Loredana Bianchi, Nicola Fui, Annalisa Rizzi, Luigi Bergantini, Laura Cillis, Giuseppe Miriana, D’ Alessandro Mazzei, Maria Antonietta Refini, Rosa Metella Sestini, Piersante Bargagli, Elena Rottoli, Paola Respir Res Research BACKGROUND: Serum chitotriosidase is a promising biomarker that has shown high specificity and sensitivity in patients with sarcoidosis. The aim of this study was to investigate correlations between serum chitotriosidase, clinical phenotypes, disease localizations and different radiological lung involvement and to identify clinical features associated with over-expression of chitotriosidase in a large cohort of sarcoidosis patients. METHODS: Chitotriosidase activity was evaluated in a population of 694 consecutive patients (males 39%, age 55.8 ± 12.8 years). Clinical and respiratory functional characteristics, Clinical Outcome Scale (COS) classification, clinical phenotypes proposed by the GenPhenResA project, and radiological assessment, including CT scan, were collected. Serum sampling and clinical and functional assessments at follow-up were also included. RESULTS: Significantly higher chitotriosidase activity was observed in sarcoidosis patients than in healthy controls (p < 0.0001). Evidence of lung fibrosis with reticular abnormalities and traction bronchiectasis at High resolution CT, presence of multiple extrapulmonary sarcoid localizations and increased 24-h urinary excretion of calcium were associated with significantly higher chitotriosidase activity (p < 0.005). Patients with remitted or minimal disease had lower values of chitotriosidase than patients with persistent disease. At follow-up, patients who required an increase in steroid dose showed an increase in its activity. CONCLUSIONS: Chitotriosidase is a reliable biomarker of sarcoidosis. It is increased in patients with sarcoidosis correlating with disease activity, severity and multiorgan dissemination. Steroid therapy tended to reduce chitotriosidase expression, however it responded in cases of disease relapse. BioMed Central 2020-01-06 2020 /pmc/articles/PMC6945638/ /pubmed/31906975 http://dx.doi.org/10.1186/s12931-019-1263-z Text en © The Author(s). 2020 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Bennett, David Cameli, Paolo Lanzarone, Nicola Carobene, Loredana Bianchi, Nicola Fui, Annalisa Rizzi, Luigi Bergantini, Laura Cillis, Giuseppe Miriana, D’ Alessandro Mazzei, Maria Antonietta Refini, Rosa Metella Sestini, Piersante Bargagli, Elena Rottoli, Paola Chitotriosidase: a biomarker of activity and severity in patients with sarcoidosis |
title | Chitotriosidase: a biomarker of activity and severity in patients with sarcoidosis |
title_full | Chitotriosidase: a biomarker of activity and severity in patients with sarcoidosis |
title_fullStr | Chitotriosidase: a biomarker of activity and severity in patients with sarcoidosis |
title_full_unstemmed | Chitotriosidase: a biomarker of activity and severity in patients with sarcoidosis |
title_short | Chitotriosidase: a biomarker of activity and severity in patients with sarcoidosis |
title_sort | chitotriosidase: a biomarker of activity and severity in patients with sarcoidosis |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6945638/ https://www.ncbi.nlm.nih.gov/pubmed/31906975 http://dx.doi.org/10.1186/s12931-019-1263-z |
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