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Comparative Cytogenetic Analysis of Spontaneous Abortions in Recurrent and Sporadic Pregnancy Losses
BACKGROUND: The majority of miscarriages are sporadic; however, 1–5% of couples experience recurrent pregnancy loss (RPL). Approximately 50–60% of miscarriages result from chromosomal abnormalities. Currently, there are conflicting reports regarding the rates of chromosomal abnormalities between rec...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
S. Karger AG
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6945958/ https://www.ncbi.nlm.nih.gov/pubmed/31988885 http://dx.doi.org/10.1159/000446099 |
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author | Nikitina, Tatiana V. Sazhenova, Elena A. Tolmacheva, Ekaterina N. Sukhanova, Natalia N. Kashevarova, Anna A. Skryabin, Nikolay A. Vasilyev, Stanislav A. Nemtseva, Tatiana N. Yuriev, Sergey Y. Lebedev, Igor N. |
author_facet | Nikitina, Tatiana V. Sazhenova, Elena A. Tolmacheva, Ekaterina N. Sukhanova, Natalia N. Kashevarova, Anna A. Skryabin, Nikolay A. Vasilyev, Stanislav A. Nemtseva, Tatiana N. Yuriev, Sergey Y. Lebedev, Igor N. |
author_sort | Nikitina, Tatiana V. |
collection | PubMed |
description | BACKGROUND: The majority of miscarriages are sporadic; however, 1–5% of couples experience recurrent pregnancy loss (RPL). Approximately 50–60% of miscarriages result from chromosomal abnormalities. Currently, there are conflicting reports regarding the rates of chromosomal abnormalities between recurrent and sporadic pregnancy losses. METHODS: A retrospective comparative cytogenetic analysis of 442 RPL and 466 sporadic abortions (SA) was performed. Maternal age and medical background were evaluated, and chromosomal abnormality rates were compared between groups. RESULTS: The frequency of embryos with abnormal karyotypes was significantly higher in SA compared to RPL (56.7 and 46.6%, respectively), and abortions from women under 30 years of age were the main contributor to this difference. An age-dependent increase in the abnormal karyotype rate was observed in two groups of women - those with SA [53.0 and 70.1% for younger and older (≥35-year-old) mothers, respectively] and those with idiopathic RPL without any concomitant reproductive pathology (46.5 and 78.4% for younger and older mothers) - but not in the group of women with RPL associated with concomitant reproductive pathology. The incidence of recurrent abnormal karyotypes in subsequent miscarriages was significantly higher than random probability (odds ratio = 22.75). CONCLUSION: Our findings highlight the variability in the risk of aneuploidy in recurrent abortion. |
format | Online Article Text |
id | pubmed-6945958 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | S. Karger AG |
record_format | MEDLINE/PubMed |
spelling | pubmed-69459582020-01-27 Comparative Cytogenetic Analysis of Spontaneous Abortions in Recurrent and Sporadic Pregnancy Losses Nikitina, Tatiana V. Sazhenova, Elena A. Tolmacheva, Ekaterina N. Sukhanova, Natalia N. Kashevarova, Anna A. Skryabin, Nikolay A. Vasilyev, Stanislav A. Nemtseva, Tatiana N. Yuriev, Sergey Y. Lebedev, Igor N. Biomed Hub Research Article BACKGROUND: The majority of miscarriages are sporadic; however, 1–5% of couples experience recurrent pregnancy loss (RPL). Approximately 50–60% of miscarriages result from chromosomal abnormalities. Currently, there are conflicting reports regarding the rates of chromosomal abnormalities between recurrent and sporadic pregnancy losses. METHODS: A retrospective comparative cytogenetic analysis of 442 RPL and 466 sporadic abortions (SA) was performed. Maternal age and medical background were evaluated, and chromosomal abnormality rates were compared between groups. RESULTS: The frequency of embryos with abnormal karyotypes was significantly higher in SA compared to RPL (56.7 and 46.6%, respectively), and abortions from women under 30 years of age were the main contributor to this difference. An age-dependent increase in the abnormal karyotype rate was observed in two groups of women - those with SA [53.0 and 70.1% for younger and older (≥35-year-old) mothers, respectively] and those with idiopathic RPL without any concomitant reproductive pathology (46.5 and 78.4% for younger and older mothers) - but not in the group of women with RPL associated with concomitant reproductive pathology. The incidence of recurrent abnormal karyotypes in subsequent miscarriages was significantly higher than random probability (odds ratio = 22.75). CONCLUSION: Our findings highlight the variability in the risk of aneuploidy in recurrent abortion. S. Karger AG 2016-04-27 /pmc/articles/PMC6945958/ /pubmed/31988885 http://dx.doi.org/10.1159/000446099 Text en Copyright © 2016 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc/4.0/ This article is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission. |
spellingShingle | Research Article Nikitina, Tatiana V. Sazhenova, Elena A. Tolmacheva, Ekaterina N. Sukhanova, Natalia N. Kashevarova, Anna A. Skryabin, Nikolay A. Vasilyev, Stanislav A. Nemtseva, Tatiana N. Yuriev, Sergey Y. Lebedev, Igor N. Comparative Cytogenetic Analysis of Spontaneous Abortions in Recurrent and Sporadic Pregnancy Losses |
title | Comparative Cytogenetic Analysis of Spontaneous Abortions in Recurrent and Sporadic Pregnancy Losses |
title_full | Comparative Cytogenetic Analysis of Spontaneous Abortions in Recurrent and Sporadic Pregnancy Losses |
title_fullStr | Comparative Cytogenetic Analysis of Spontaneous Abortions in Recurrent and Sporadic Pregnancy Losses |
title_full_unstemmed | Comparative Cytogenetic Analysis of Spontaneous Abortions in Recurrent and Sporadic Pregnancy Losses |
title_short | Comparative Cytogenetic Analysis of Spontaneous Abortions in Recurrent and Sporadic Pregnancy Losses |
title_sort | comparative cytogenetic analysis of spontaneous abortions in recurrent and sporadic pregnancy losses |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6945958/ https://www.ncbi.nlm.nih.gov/pubmed/31988885 http://dx.doi.org/10.1159/000446099 |
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