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An investigation into the avoidability of adverse drug reactions using the LAAT and modified Hallas tools

An adverse drug reactions avoidability tool called the Liverpool ADR avoidability assessment tool (LAAT) was recently developed (for research purposes), and subsequently validated with mixed interrater reliability (IRR). We investigated the comparative IRR of this tool in an inpatient cohort to asce...

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Autores principales: Danjuma, Mohammed Ibn-Mas’ud, Shokri, Shaikha Al, Abubeker, Ibrahim Y., Malik, Ashraf El, Abdallah, Ibtihal Mahmoud Hassan, Shafei, Mohamed Nabil El, Fatima, Haajra, Mahmoud, Mohamed, Hussain, Tanweer, Maghoub, Yahya, Sajid, Jamal, Zouki, Abdel Naser El
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6946216/
https://www.ncbi.nlm.nih.gov/pubmed/31895800
http://dx.doi.org/10.1097/MD.0000000000018569
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author Danjuma, Mohammed Ibn-Mas’ud
Shokri, Shaikha Al
Abubeker, Ibrahim Y.
Malik, Ashraf El
Abdallah, Ibtihal Mahmoud Hassan
Shafei, Mohamed Nabil El
Fatima, Haajra
Mahmoud, Mohamed
Hussain, Tanweer
Maghoub, Yahya
Sajid, Jamal
Zouki, Abdel Naser El
author_facet Danjuma, Mohammed Ibn-Mas’ud
Shokri, Shaikha Al
Abubeker, Ibrahim Y.
Malik, Ashraf El
Abdallah, Ibtihal Mahmoud Hassan
Shafei, Mohamed Nabil El
Fatima, Haajra
Mahmoud, Mohamed
Hussain, Tanweer
Maghoub, Yahya
Sajid, Jamal
Zouki, Abdel Naser El
author_sort Danjuma, Mohammed Ibn-Mas’ud
collection PubMed
description An adverse drug reactions avoidability tool called the Liverpool ADR avoidability assessment tool (LAAT) was recently developed (for research purposes), and subsequently validated with mixed interrater reliability (IRR). We investigated the comparative IRR of this tool in an inpatient cohort to ascertain its practical application in this setting. The patient population was comprised of 44 ADR drug pairs drawn from an observational prospective cohort of patents with ADR attending a Weill Cornell Medicine-affiliated tertiary medical Centre in Doha Qatar (Hamad General Hospital). Using the LAAT, and modified Hallas tools, 4 independent raters (2 Clinical Pharmacologists, and 2 General Physicians) assessed and scored the 44 ADR-drug pairs. Agreement proportions between the rating pairs were evaluated as well individual/overall kappa statistics and intraclass correlation coefficients. We evaluated the weight of each of the 7 questions on the LAAT tool to ascertain its determinative role. Across 44 ADR-drug pairs, the overall median Fleiss kappa using the LAAT, and modified Hallas tools were 0.67 (interquartile range (IQR) 0.55, 0.76), 0.36 (IQR, 0.23–0.71) respectively. The overall percentage pairwise agreement with the LAAT and modified Hallas tools were 78.5%, and 62.2% respectively. Exact pairwise agreement occurred in 37 out of 44 (range 0.71–1), and 27 of 44 (0.53–0.77) ADR-drug pairs using the LAAT and modified Hallas tools respectively. Using the LAAT tool, the overall intraclass correlation coefficient was 0.68 (CI 0.55, 0.79), and 0.37 (CI 0.22, 0.53) with the modified Hallas tool. We report a higher proportion of “possible” and “definite” avoidability outcomes of adverse drug reactions compared with the modified Hallas, or that reported by developers of the LAAT tool. Although initially developed for research purposes, our report has suggested for the first time a potential applicability of this tool in clinical environment as well.
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spelling pubmed-69462162020-01-31 An investigation into the avoidability of adverse drug reactions using the LAAT and modified Hallas tools Danjuma, Mohammed Ibn-Mas’ud Shokri, Shaikha Al Abubeker, Ibrahim Y. Malik, Ashraf El Abdallah, Ibtihal Mahmoud Hassan Shafei, Mohamed Nabil El Fatima, Haajra Mahmoud, Mohamed Hussain, Tanweer Maghoub, Yahya Sajid, Jamal Zouki, Abdel Naser El Medicine (Baltimore) 4200 An adverse drug reactions avoidability tool called the Liverpool ADR avoidability assessment tool (LAAT) was recently developed (for research purposes), and subsequently validated with mixed interrater reliability (IRR). We investigated the comparative IRR of this tool in an inpatient cohort to ascertain its practical application in this setting. The patient population was comprised of 44 ADR drug pairs drawn from an observational prospective cohort of patents with ADR attending a Weill Cornell Medicine-affiliated tertiary medical Centre in Doha Qatar (Hamad General Hospital). Using the LAAT, and modified Hallas tools, 4 independent raters (2 Clinical Pharmacologists, and 2 General Physicians) assessed and scored the 44 ADR-drug pairs. Agreement proportions between the rating pairs were evaluated as well individual/overall kappa statistics and intraclass correlation coefficients. We evaluated the weight of each of the 7 questions on the LAAT tool to ascertain its determinative role. Across 44 ADR-drug pairs, the overall median Fleiss kappa using the LAAT, and modified Hallas tools were 0.67 (interquartile range (IQR) 0.55, 0.76), 0.36 (IQR, 0.23–0.71) respectively. The overall percentage pairwise agreement with the LAAT and modified Hallas tools were 78.5%, and 62.2% respectively. Exact pairwise agreement occurred in 37 out of 44 (range 0.71–1), and 27 of 44 (0.53–0.77) ADR-drug pairs using the LAAT and modified Hallas tools respectively. Using the LAAT tool, the overall intraclass correlation coefficient was 0.68 (CI 0.55, 0.79), and 0.37 (CI 0.22, 0.53) with the modified Hallas tool. We report a higher proportion of “possible” and “definite” avoidability outcomes of adverse drug reactions compared with the modified Hallas, or that reported by developers of the LAAT tool. Although initially developed for research purposes, our report has suggested for the first time a potential applicability of this tool in clinical environment as well. Wolters Kluwer Health 2020-01-03 /pmc/articles/PMC6946216/ /pubmed/31895800 http://dx.doi.org/10.1097/MD.0000000000018569 Text en Copyright © 2020 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by/4.0 This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0
spellingShingle 4200
Danjuma, Mohammed Ibn-Mas’ud
Shokri, Shaikha Al
Abubeker, Ibrahim Y.
Malik, Ashraf El
Abdallah, Ibtihal Mahmoud Hassan
Shafei, Mohamed Nabil El
Fatima, Haajra
Mahmoud, Mohamed
Hussain, Tanweer
Maghoub, Yahya
Sajid, Jamal
Zouki, Abdel Naser El
An investigation into the avoidability of adverse drug reactions using the LAAT and modified Hallas tools
title An investigation into the avoidability of adverse drug reactions using the LAAT and modified Hallas tools
title_full An investigation into the avoidability of adverse drug reactions using the LAAT and modified Hallas tools
title_fullStr An investigation into the avoidability of adverse drug reactions using the LAAT and modified Hallas tools
title_full_unstemmed An investigation into the avoidability of adverse drug reactions using the LAAT and modified Hallas tools
title_short An investigation into the avoidability of adverse drug reactions using the LAAT and modified Hallas tools
title_sort investigation into the avoidability of adverse drug reactions using the laat and modified hallas tools
topic 4200
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6946216/
https://www.ncbi.nlm.nih.gov/pubmed/31895800
http://dx.doi.org/10.1097/MD.0000000000018569
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