Modulation of brain cation-Cl(−) cotransport via the SPAK kinase inhibitor ZT-1a

The SLC12A cation-Cl(−) cotransporters (CCC), including NKCC1 and the KCCs, are important determinants of brain ionic homeostasis. SPAK kinase (STK39) is the CCC master regulator, which stimulates NKCC1 ionic influx and inhibits KCC-mediated efflux via phosphorylation at conserved, shared motifs. Up...

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Detalles Bibliográficos
Autores principales: Zhang, Jinwei, Bhuiyan, Mohammad Iqbal H., Zhang, Ting, Karimy, Jason K., Wu, Zhijuan, Fiesler, Victoria M., Zhang, Jingfang, Huang, Huachen, Hasan, Md Nabiul, Skrzypiec, Anna E., Mucha, Mariusz, Duran, Daniel, Huang, Wei, Pawlak, Robert, Foley, Lesley M., Hitchens, T. Kevin, Minnigh, Margaret B., Poloyac, Samuel M., Alper, Seth L., Molyneaux, Bradley J., Trevelyan, Andrew J., Kahle, Kristopher T., Sun, Dandan, Deng, Xianming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6946680/
https://www.ncbi.nlm.nih.gov/pubmed/31911626
http://dx.doi.org/10.1038/s41467-019-13851-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6946680/
https://www.ncbi.nlm.nih.gov/pubmed/31911626
http://dx.doi.org/10.1038/s41467-019-13851-6

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