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Transmission of tauopathy strains is independent of their isoform composition
The deposition of pathological tau is a common feature in several neurodegenerative tauopathies. Although equal ratios of tau isoforms with 3 (3R) and 4 (4R) microtubule-binding repeats are expressed in the adult human brain, the pathological tau from different tauopathies have distinct isoform comp...
Autores principales: | He, Zhuohao, McBride, Jennifer D., Xu, Hong, Changolkar, Lakshmi, Kim, Soo-jung, Zhang, Bin, Narasimhan, Sneha, Gibbons, Garrett S., Guo, Jing L., Kozak, Michael, Schellenberg, Gerard D., Trojanowski, John Q., Lee, Virginia M. -Y. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6946697/ https://www.ncbi.nlm.nih.gov/pubmed/31911587 http://dx.doi.org/10.1038/s41467-019-13787-x |
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