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Obesity and Bone Health Revisited: A Mendelian Randomization Study for Koreans

Epidemiologic studies have replicated positive associations between obesity and bone health, but their mechanisms are still debatable. We aimed to scrutinize an association between bone health and obesity using genetic instrumental variables (IVs) with the distinction of general versus abdominal obe...

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Autores principales: Lee, Soo Ji, Lee, Joo‐Yeon, Sung, Joohon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6946936/
https://www.ncbi.nlm.nih.gov/pubmed/30817851
http://dx.doi.org/10.1002/jbmr.3678
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author Lee, Soo Ji
Lee, Joo‐Yeon
Sung, Joohon
author_facet Lee, Soo Ji
Lee, Joo‐Yeon
Sung, Joohon
author_sort Lee, Soo Ji
collection PubMed
description Epidemiologic studies have replicated positive associations between obesity and bone health, but their mechanisms are still debatable. We aimed to scrutinize an association between bone health and obesity using genetic instrumental variables (IVs) with the distinction of general versus abdominal obesity. We selected independent IVs of body mass index (BMI) and BMI‐adjusted waist circumference (aWC, a proxy of a central fat distribution) by combining novel genomewide searches from the Korean Genome Epidemiology Study (KoGES) consortium and existing reports. We evaluated the associations of obesity indices with bone health measures for weight‐bearing and non–weight‐bearing bones, applying standard Mendelian randomization analyses. The IVs for BMI and aWC selected from KoGES cohort studies (n = 14,389) explained its own trait only, negating the mutual correlation at the phenotypic level. Two‐stage least squares analyses using an independent cohort study (n = 2507, mean age = 44.4 years, men = 44.3%) showed that BMI but not aWC was positively associated with bone mineral density (BMD for weight‐bearing bones: 0.063 ± 0.016 g/cm(2) per one standard deviation increase in BMI), implying the fat distribution might be neutral. The association was weaker for non–weight‐bearing bones (BMI on BMD: 0.034 ± 0.011 g/cm(2)), and for postmenopausal women the association was absent. Obesity increased both bone area and bone mineral content (BMC) to a lesser degree, but the increase in BMC was not evident for menopausal women. When we stratified the weight into lean body mass and fat mass, the increase in BMD was more evident for lean body mass, and fat mass showed a beneficial role only for men and premenopausal women. Our findings suggest that bone health might gain little from obesity, if any, through its added weight, and other means to prevent bone loss would be essential for postmenopausal women. © 2019 American Society for Bone and Mineral Research.
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spelling pubmed-69469362020-01-09 Obesity and Bone Health Revisited: A Mendelian Randomization Study for Koreans Lee, Soo Ji Lee, Joo‐Yeon Sung, Joohon J Bone Miner Res Original Articles Epidemiologic studies have replicated positive associations between obesity and bone health, but their mechanisms are still debatable. We aimed to scrutinize an association between bone health and obesity using genetic instrumental variables (IVs) with the distinction of general versus abdominal obesity. We selected independent IVs of body mass index (BMI) and BMI‐adjusted waist circumference (aWC, a proxy of a central fat distribution) by combining novel genomewide searches from the Korean Genome Epidemiology Study (KoGES) consortium and existing reports. We evaluated the associations of obesity indices with bone health measures for weight‐bearing and non–weight‐bearing bones, applying standard Mendelian randomization analyses. The IVs for BMI and aWC selected from KoGES cohort studies (n = 14,389) explained its own trait only, negating the mutual correlation at the phenotypic level. Two‐stage least squares analyses using an independent cohort study (n = 2507, mean age = 44.4 years, men = 44.3%) showed that BMI but not aWC was positively associated with bone mineral density (BMD for weight‐bearing bones: 0.063 ± 0.016 g/cm(2) per one standard deviation increase in BMI), implying the fat distribution might be neutral. The association was weaker for non–weight‐bearing bones (BMI on BMD: 0.034 ± 0.011 g/cm(2)), and for postmenopausal women the association was absent. Obesity increased both bone area and bone mineral content (BMC) to a lesser degree, but the increase in BMC was not evident for menopausal women. When we stratified the weight into lean body mass and fat mass, the increase in BMD was more evident for lean body mass, and fat mass showed a beneficial role only for men and premenopausal women. Our findings suggest that bone health might gain little from obesity, if any, through its added weight, and other means to prevent bone loss would be essential for postmenopausal women. © 2019 American Society for Bone and Mineral Research. John Wiley and Sons Inc. 2019-02-28 2019-06 /pmc/articles/PMC6946936/ /pubmed/30817851 http://dx.doi.org/10.1002/jbmr.3678 Text en © 2019 The Authors. Journal of Bone and Mineral Research published by American Society for Bone and Mineral Research This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Original Articles
Lee, Soo Ji
Lee, Joo‐Yeon
Sung, Joohon
Obesity and Bone Health Revisited: A Mendelian Randomization Study for Koreans
title Obesity and Bone Health Revisited: A Mendelian Randomization Study for Koreans
title_full Obesity and Bone Health Revisited: A Mendelian Randomization Study for Koreans
title_fullStr Obesity and Bone Health Revisited: A Mendelian Randomization Study for Koreans
title_full_unstemmed Obesity and Bone Health Revisited: A Mendelian Randomization Study for Koreans
title_short Obesity and Bone Health Revisited: A Mendelian Randomization Study for Koreans
title_sort obesity and bone health revisited: a mendelian randomization study for koreans
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6946936/
https://www.ncbi.nlm.nih.gov/pubmed/30817851
http://dx.doi.org/10.1002/jbmr.3678
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