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Mitomycin C in the Endoscopic Treatment of Laryngotracheal Stenosis: Systematic Review and Proportional Meta-Analysis

Introduction  Mitomycin C is a natural antibiotic that has been used to inhibit the proliferation of fibroblasts in scar tissue. Objective  To evaluate the effectiveness and safety of topical Mitomycin C as an adjuvant in the endoscopic treatment of laryngotracheal stenoses. Data synthesis  A system...

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Autores principales: Queiroga, Thereza L. O., Cataneo, Daniele C., Martins, Regina H. G., Reis, Tarcisio A., Cataneo, Antônio J. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Thieme Revinter Publicações Ltda 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6946955/
https://www.ncbi.nlm.nih.gov/pubmed/31915466
http://dx.doi.org/10.1055/s-0039-1700582
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author Queiroga, Thereza L. O.
Cataneo, Daniele C.
Martins, Regina H. G.
Reis, Tarcisio A.
Cataneo, Antônio J. M.
author_facet Queiroga, Thereza L. O.
Cataneo, Daniele C.
Martins, Regina H. G.
Reis, Tarcisio A.
Cataneo, Antônio J. M.
author_sort Queiroga, Thereza L. O.
collection PubMed
description Introduction  Mitomycin C is a natural antibiotic that has been used to inhibit the proliferation of fibroblasts in scar tissue. Objective  To evaluate the effectiveness and safety of topical Mitomycin C as an adjuvant in the endoscopic treatment of laryngotracheal stenoses. Data synthesis  A systematic review of experimental or observational studies that have evaluated the treatment of laryngotracheal stenoses with the use of topical Mitomycin C was performed. Databases researched: LILACS, PubMed, Embase, Cochrane and Web of Science. Outcomes: resolution (symptom-free time ≥ one year), number of procedures required, and complications resulting from the procedure. A total of 15 studies (involving 387 patients) were selected. Mitomycin C was administered to every patient in 11 studies, and in 4 other studies, the patients were separated into 2 groups, 1 receiving mitomycin C, and the other not. The resolution of the stenosis evaluated in 12 studies in which the patients received mitomycin C was of 69% (95% confidence interval [95%CI]: 61–76%; I (2)  = 17.3%). A total of 52% of the patients (95%CI: 39–64%, 11 studies; I (2)  = 64.7%) were submitted to a single endoscopic procedure, and 48% (95%CI: 36–61%, 11 studies; I (2)  = 64.7%) were submitted to more than 1 procedure. Complications (mediastinal and subcutaneous emphysema, dysphonia, laceration or vocal fold paralysis and acute light obstruction) were reported in 9% of the patients (95%CI: 3–18%, 9 studies; I (2)  = 79.8%). Conclusions  The evidence suggests that mitomycin C is an effective and safe option in the endoscopic treatment of laryngotracheal stenosis.
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spelling pubmed-69469552020-01-08 Mitomycin C in the Endoscopic Treatment of Laryngotracheal Stenosis: Systematic Review and Proportional Meta-Analysis Queiroga, Thereza L. O. Cataneo, Daniele C. Martins, Regina H. G. Reis, Tarcisio A. Cataneo, Antônio J. M. Int Arch Otorhinolaryngol Introduction  Mitomycin C is a natural antibiotic that has been used to inhibit the proliferation of fibroblasts in scar tissue. Objective  To evaluate the effectiveness and safety of topical Mitomycin C as an adjuvant in the endoscopic treatment of laryngotracheal stenoses. Data synthesis  A systematic review of experimental or observational studies that have evaluated the treatment of laryngotracheal stenoses with the use of topical Mitomycin C was performed. Databases researched: LILACS, PubMed, Embase, Cochrane and Web of Science. Outcomes: resolution (symptom-free time ≥ one year), number of procedures required, and complications resulting from the procedure. A total of 15 studies (involving 387 patients) were selected. Mitomycin C was administered to every patient in 11 studies, and in 4 other studies, the patients were separated into 2 groups, 1 receiving mitomycin C, and the other not. The resolution of the stenosis evaluated in 12 studies in which the patients received mitomycin C was of 69% (95% confidence interval [95%CI]: 61–76%; I (2)  = 17.3%). A total of 52% of the patients (95%CI: 39–64%, 11 studies; I (2)  = 64.7%) were submitted to a single endoscopic procedure, and 48% (95%CI: 36–61%, 11 studies; I (2)  = 64.7%) were submitted to more than 1 procedure. Complications (mediastinal and subcutaneous emphysema, dysphonia, laceration or vocal fold paralysis and acute light obstruction) were reported in 9% of the patients (95%CI: 3–18%, 9 studies; I (2)  = 79.8%). Conclusions  The evidence suggests that mitomycin C is an effective and safe option in the endoscopic treatment of laryngotracheal stenosis. Thieme Revinter Publicações Ltda 2020-01 2019-12-20 /pmc/articles/PMC6946955/ /pubmed/31915466 http://dx.doi.org/10.1055/s-0039-1700582 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License, which permits unrestricted reproduction and distribution, for non-commercial purposes only; and use and reproduction, but not distribution, of adapted material for non-commercial purposes only, provided the original work is properly cited.
spellingShingle Queiroga, Thereza L. O.
Cataneo, Daniele C.
Martins, Regina H. G.
Reis, Tarcisio A.
Cataneo, Antônio J. M.
Mitomycin C in the Endoscopic Treatment of Laryngotracheal Stenosis: Systematic Review and Proportional Meta-Analysis
title Mitomycin C in the Endoscopic Treatment of Laryngotracheal Stenosis: Systematic Review and Proportional Meta-Analysis
title_full Mitomycin C in the Endoscopic Treatment of Laryngotracheal Stenosis: Systematic Review and Proportional Meta-Analysis
title_fullStr Mitomycin C in the Endoscopic Treatment of Laryngotracheal Stenosis: Systematic Review and Proportional Meta-Analysis
title_full_unstemmed Mitomycin C in the Endoscopic Treatment of Laryngotracheal Stenosis: Systematic Review and Proportional Meta-Analysis
title_short Mitomycin C in the Endoscopic Treatment of Laryngotracheal Stenosis: Systematic Review and Proportional Meta-Analysis
title_sort mitomycin c in the endoscopic treatment of laryngotracheal stenosis: systematic review and proportional meta-analysis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6946955/
https://www.ncbi.nlm.nih.gov/pubmed/31915466
http://dx.doi.org/10.1055/s-0039-1700582
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