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No excessive mutations in transcription activator-like effector nuclease-mediated α-1,3-galactosyltransferase knockout Yucatan miniature pigs

OBJECTIVE: Specific genomic sites can be recognized and permanently modified by genome editing. The discovery of endonucleases has advanced genome editing in pigs, attenuating xenograft rejection and cross-species disease transmission. However, off-target mutagenesis caused by these nucleases is a m...

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Detalles Bibliográficos
Autores principales:	Choi, Kimyung, Shim, Joohyun, Ko, Nayoung, Park, Joonghoon
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Asian-Australasian Association of Animal Production Societies (AAAP) and Korean Society of Animal Science and Technology (KSAST) 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6946973/ https://www.ncbi.nlm.nih.gov/pubmed/31480150 http://dx.doi.org/10.5713/ajas.19.0480

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