Cargando…

Regorafenib CSF Penetration, Efficacy, and MRI Patterns in Recurrent Malignant Glioma Patients

(1) Background: The phase 2 Regorafenib in Relapsed Glioblastoma (REGOMA) trial indicated a survival benefit for patients with first recurrence of a glioblastoma when treated with the multikinase inhibitor regorafenib (REG) instead of lomustine. The aim of this retrospective study was to investigate...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zeiner, Pia S., Kinzig, Martina, Divé, Iris, Maurer, Gabriele D., Filipski, Katharina, Harter, Patrick N., Senft, Christian, Bähr, Oliver, Hattingen, Elke, Steinbach, Joachim P., Sörgel, Fritz, Voss, Martin, Steidl, Eike, Ronellenfitsch, Michael W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6947028/ https://www.ncbi.nlm.nih.gov/pubmed/31766326 http://dx.doi.org/10.3390/jcm8122031

Ejemplares similares

A 25-year retrospective, single center analysis of 343 WHO grade II/III glioma patients: implications for grading and temozolomide therapy
por: Steidl, Eike, et al.
Publicado: (2021)

Longitudinal study on MRI and neuropathological findings: Neither DSC-perfusion derived rCBV(max) nor vessel densities correlate between newly diagnosed and progressive glioblastoma
por: Steidl, Eike, et al.
Publicado: (2023)

Myoinositol as a Biomarker in Recurrent Glioblastoma Treated with Bevacizumab: A (1)H-Magnetic Resonance Spectroscopy Study
por: Steidl, Eike, et al.
Publicado: (2016)

Gliomatosis cerebri (GC) growth pattern: A single-center analysis of clinical, histological, and molecular characteristics of GC and non-GC glioblastoma
por: Divé, Iris, et al.
Publicado: (2023)

Immune Checkpoint Inhibitor-Induced Cerebral Pseudoprogression: Patterns and Categorization
por: Urban, Hans, et al.
Publicado: (2022)

Lack of H3K27 trimethylation is associated with 1p/19q codeletion in diffuse gliomas
por: Filipski, Katharina, et al.
Publicado: (2019)

Akt and mTORC1 signaling as predictive biomarkers for the EGFR antibody nimotuzumab in glioblastoma
por: Ronellenfitsch, Michael W., et al.
Publicado: (2018)

Perioperative cerebral ischemia promote infiltrative recurrence in glioblastoma
por: Thiepold, Anna-Luisa, et al.
Publicado: (2015)

The Acute Superficial Siderosis Syndrome — Clinical Entity, Imaging Findings, and Histopathology
por: Friedauer, Lucie, et al.
Publicado: (2022)

Molecular matched targeted therapies for primary brain tumors—a single center retrospective analysis
por: Luger, Anna-Luisa, et al.
Publicado: (2022)

Penetration of Isavuconazole in Ascites Fluid of Critically Ill Patients
por: Lahmer, Tobias, et al.
Publicado: (2021)

Sequential implementation of DSC-MR perfusion and dynamic [(18)F]FET PET allows efficient differentiation of glioma progression from treatment-related changes
por: Steidl, Eike, et al.
Publicado: (2020)

Caffeine, Paraxanthine, Theophylline, and Theobromine Content in Human Milk
por: Purkiewicz, Aleksandra, et al.
Publicado: (2022)

Differential utilization of ketone bodies by neurons and glioma cell lines: a rationale for ketogenic diet as experimental glioma therapy
por: Maurer, Gabriele D, et al.
Publicado: (2011)

Influence of VEGF-A, VEGFR-1-3, and neuropilin 1-2 on progression-free: and overall survival in WHO grade II and III meningioma patients
por: Bernatz, Simon, et al.
Publicado: (2021)

Matching Quantitative MRI Parameters with Histological Features of Treatment-Naïve IDH Wild-Type Glioma
por: Maurer, Gabriele D., et al.
Publicado: (2021)

Activation of Epidermal Growth Factor Receptor Sensitizes Glioblastoma Cells to Hypoxia-Induced Cell Death
por: Luger, Anna-Luisa, et al.
Publicado: (2020)

Bioequivalence of HX575 (recombinant human epoetin alfa) and a comparator epoetin alfa after multiple intravenous administrations: an open-label randomised controlled trial
por: Sörgel, Fritz, et al.
Publicado: (2009)

Comparability of Biosimilar Filgrastim with Originator Filgrastim: Protein Characterization, Pharmacodynamics, and Pharmacokinetics
por: Sörgel, Fritz, et al.
Publicado: (2015)

Phospholipid Metabolites in Recurrent Glioblastoma: In Vivo Markers Detect Different Tumor Phenotypes before and under Antiangiogenic Therapy
por: Hattingen, Elke, et al.
Publicado: (2013)

Adrenal Insufficiency in Patients with Corticosteroid-Refractory Cerebral Radiation Necrosis Treated with Bevacizumab
por: Voss, Martin, et al.
Publicado: (2019)

A Paravermal Trans-Cerebellar Approach to the Posterior Fossa Tumor Causes Hypertrophic Olivary Degeneration by Dentate Nucleus Injury
por: Schaller-Paule, Martin A., et al.
Publicado: (2021)

Short-term fasting in glioma patients: analysis of diet diaries and metabolic parameters of the ERGO2 trial
por: Voss, Martin, et al.
Publicado: (2021)

Tissue pharmacokinetics of individual macrolides support observed differences in development of bacterial resistance
por: Krasniqi, Shaip, et al.
Publicado: (2010)

MR imaging profile and histopathological characteristics of tumour vasculature, cell density and proliferation rate define two distinct growth patterns of human brain metastases from lung cancer
por: Kiyose, Makoto, et al.
Publicado: (2022)

Dabrafenib in patients with recurrent, BRAF V600E mutated malignant glioma and leptomeningeal disease
por: Burger, Michael C., et al.
Publicado: (2017)

Second Generation mTOR Inhibitors as a Double-Edged Sword in Malignant Glioma Treatment
por: Heinzen, Dennis, et al.
Publicado: (2019)

Clinical Outcome and Risk Factors of Red Blood Cell Transfusion in Patients Undergoing Elective Primary Meningioma Resection
por: Neef, Vanessa, et al.
Publicado: (2021)

Meningioma Surgery in Patients ≥70 Years of Age: Clinical Outcome and Validation of the SKALE Score
por: Monden, Daniel, et al.
Publicado: (2021)

Ventriculoperitoneal Shunts Equipped with On-Off Valves for Intraventricular Therapies in Patients with Communicating Hydrocephalus due to Leptomeningeal Metastases
por: Burger, Michael C., et al.
Publicado: (2018)

Inhibition of mTOR signaling protects human glioma cells from hypoxia-induced cell death in an autophagy-independent manner
por: Divé, Iris, et al.
Publicado: (2022)

Continuous vs bolus administration of imipenem in critically ill patients with ICU-acquired pneumonia
por: Sakka, S, et al.
Publicado: (2004)

Distribution and prognostic relevance of tumor-infiltrating lymphocytes (TILs) and PD-1/PD-L1 immune checkpoints in human brain metastases
por: Harter, Patrick N., et al.
Publicado: (2015)

Intracranial injection of natural killer cells engineered with a HER2-targeted chimeric antigen receptor in patients with recurrent glioblastoma
por: Burger, Michael C, et al.
Publicado: (2023)

Non-Invasive Measurement of Drug and 2-HG Signals Using (19)F and (1)H MR Spectroscopy in Brain Tumors Treated with the Mutant IDH1 Inhibitor BAY1436032
por: Wenger, Katharina J., et al.
Publicado: (2020)

ERGO: A pilot study of ketogenic diet in recurrent glioblastoma
por: RIEGER, JOHANNES, et al.
Publicado: (2014)

SARS-CoV-2 viral load dynamics in immunocompromised critically ill patients on remdesivir treatment
por: Lahmer, Tobias, et al.
Publicado: (2022)

Qualitative and quantitative detectability of hypertrophic olivary degeneration in T2, FLAIR, PD, and DTI: A prospective MRI study
por: Steidl, Eike, et al.
Publicado: (2022)

DNA methylation-based prediction of response to immune checkpoint inhibition in metastatic melanoma
por: Filipski, Katharina, et al.
Publicado: (2021)

P44 Nosocomial neurosurgical meningitis due to XDR Pseudomonas aeruginosa: clinical experience with cefiderocol
por: Stevenson, D. R., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_ckkisq1siqdo19ktj77u0m1ult