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Impact of Simultaneous Consideration of Cardiac and Vascular Function on Long-Term All-Cause and Cardiovascular Mortality

Background: Left ventricular ejection fraction (LVEF) is a good indicator of cardiac function, and brachial-ankle pulse wave velocity (baPWV) is a good indicator of vascular function. Both of them can predict cardiovascular (CV) outcomes. Objectives: There is scarce literature discussing the impact...

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Autores principales: Hsu, Po-Chao, Lee, Wen-Hsien, Tsai, Wei-Chung, Chu, Chun-Yuan, Chen, Ying-Chih, Lee, Meng-Kuang, Lin, Tsung-Hsien, Lee, Chee-Siong, Voon, Wen-Chol, Lai, Wen-Ter, Sheu, Sheng-Hsiung, Su, Ho-Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6947191/
https://www.ncbi.nlm.nih.gov/pubmed/31817192
http://dx.doi.org/10.3390/jcm8122145
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author Hsu, Po-Chao
Lee, Wen-Hsien
Tsai, Wei-Chung
Chu, Chun-Yuan
Chen, Ying-Chih
Lee, Meng-Kuang
Lin, Tsung-Hsien
Lee, Chee-Siong
Voon, Wen-Chol
Lai, Wen-Ter
Sheu, Sheng-Hsiung
Su, Ho-Ming
author_facet Hsu, Po-Chao
Lee, Wen-Hsien
Tsai, Wei-Chung
Chu, Chun-Yuan
Chen, Ying-Chih
Lee, Meng-Kuang
Lin, Tsung-Hsien
Lee, Chee-Siong
Voon, Wen-Chol
Lai, Wen-Ter
Sheu, Sheng-Hsiung
Su, Ho-Ming
author_sort Hsu, Po-Chao
collection PubMed
description Background: Left ventricular ejection fraction (LVEF) is a good indicator of cardiac function, and brachial-ankle pulse wave velocity (baPWV) is a good indicator of vascular function. Both of them can predict cardiovascular (CV) outcomes. Objectives: There is scarce literature discussing the impact of simultaneous consideration of cardiac and vascular function on overall and CV mortality. Methods: We included 958 patients and classified them into four groups. Groups 1 to 4 were patients with LVEF ≥ 50% and baPWV below the median, LVEF < 50% but baPWV below the median, LVEF ≥ 50% but baPWV above the median, and LVEF < 50% and baPWV above the median, respectively. Results: The median follow-up to mortality was 93 (25th–75th percentile: 69–101) months. There were 91 cases of CV mortality and 238 cases of all-cause mortality. After multivariable analysis, age, gender, diabetes, mean blood pressure, group 2 versus group 1, and group 4 versus group 1 were significant predictors of all-cause mortality (P ≤ 0.038) and age, diabetes, mean blood pressure, group 2 versus group 1, and group 4 versus group 1 were significant predictors of CV mortality (P ≤ 0.008). Conclusions: Patients with higher LVEF and lower baPWV had a similar overall and CV mortality as patients with higher LVEF and baPWV. Patients with lower LVEF and higher baPWV had the highest overall and CV mortality among the four study groups. In addition, patients with lower LVEF alone had a higher CV mortality than the patients with higher baPWV alone. Therefore, simultaneous consideration of cardiac and vascular function may be useful in predicting overall and CV mortality.
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spelling pubmed-69471912020-01-13 Impact of Simultaneous Consideration of Cardiac and Vascular Function on Long-Term All-Cause and Cardiovascular Mortality Hsu, Po-Chao Lee, Wen-Hsien Tsai, Wei-Chung Chu, Chun-Yuan Chen, Ying-Chih Lee, Meng-Kuang Lin, Tsung-Hsien Lee, Chee-Siong Voon, Wen-Chol Lai, Wen-Ter Sheu, Sheng-Hsiung Su, Ho-Ming J Clin Med Article Background: Left ventricular ejection fraction (LVEF) is a good indicator of cardiac function, and brachial-ankle pulse wave velocity (baPWV) is a good indicator of vascular function. Both of them can predict cardiovascular (CV) outcomes. Objectives: There is scarce literature discussing the impact of simultaneous consideration of cardiac and vascular function on overall and CV mortality. Methods: We included 958 patients and classified them into four groups. Groups 1 to 4 were patients with LVEF ≥ 50% and baPWV below the median, LVEF < 50% but baPWV below the median, LVEF ≥ 50% but baPWV above the median, and LVEF < 50% and baPWV above the median, respectively. Results: The median follow-up to mortality was 93 (25th–75th percentile: 69–101) months. There were 91 cases of CV mortality and 238 cases of all-cause mortality. After multivariable analysis, age, gender, diabetes, mean blood pressure, group 2 versus group 1, and group 4 versus group 1 were significant predictors of all-cause mortality (P ≤ 0.038) and age, diabetes, mean blood pressure, group 2 versus group 1, and group 4 versus group 1 were significant predictors of CV mortality (P ≤ 0.008). Conclusions: Patients with higher LVEF and lower baPWV had a similar overall and CV mortality as patients with higher LVEF and baPWV. Patients with lower LVEF and higher baPWV had the highest overall and CV mortality among the four study groups. In addition, patients with lower LVEF alone had a higher CV mortality than the patients with higher baPWV alone. Therefore, simultaneous consideration of cardiac and vascular function may be useful in predicting overall and CV mortality. MDPI 2019-12-04 /pmc/articles/PMC6947191/ /pubmed/31817192 http://dx.doi.org/10.3390/jcm8122145 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Hsu, Po-Chao
Lee, Wen-Hsien
Tsai, Wei-Chung
Chu, Chun-Yuan
Chen, Ying-Chih
Lee, Meng-Kuang
Lin, Tsung-Hsien
Lee, Chee-Siong
Voon, Wen-Chol
Lai, Wen-Ter
Sheu, Sheng-Hsiung
Su, Ho-Ming
Impact of Simultaneous Consideration of Cardiac and Vascular Function on Long-Term All-Cause and Cardiovascular Mortality
title Impact of Simultaneous Consideration of Cardiac and Vascular Function on Long-Term All-Cause and Cardiovascular Mortality
title_full Impact of Simultaneous Consideration of Cardiac and Vascular Function on Long-Term All-Cause and Cardiovascular Mortality
title_fullStr Impact of Simultaneous Consideration of Cardiac and Vascular Function on Long-Term All-Cause and Cardiovascular Mortality
title_full_unstemmed Impact of Simultaneous Consideration of Cardiac and Vascular Function on Long-Term All-Cause and Cardiovascular Mortality
title_short Impact of Simultaneous Consideration of Cardiac and Vascular Function on Long-Term All-Cause and Cardiovascular Mortality
title_sort impact of simultaneous consideration of cardiac and vascular function on long-term all-cause and cardiovascular mortality
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6947191/
https://www.ncbi.nlm.nih.gov/pubmed/31817192
http://dx.doi.org/10.3390/jcm8122145
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