Cargando…

Clinical Utility of Ghrelin-O-Acyltransferase (GOAT) Enzyme as a Diagnostic Tool and Potential Therapeutic Target in Prostate Cancer

Recent data suggested that plasma Ghrelin O-Acyl Transferase enzyme (GOAT) levels could represent a new diagnostic biomarker for prostate cancer (PCa). In this study, we aimed to explore the diagnostic and prognostic/aggressiveness capacity of GOAT in urine, as well as to interrogate its putative pa...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jiménez-Vacas, Juan M., Gómez-Gómez, Enrique, Montero-Hidalgo, Antonio J., Herrero-Aguayo, Vicente, L-López, Fernando, Sánchez-Sánchez, Rafael, Guler, Ipek, Blanca, Ana, Méndez-Vidal, María José, Carrasco, Julia, Lopez-Miranda, José, Requena-Tapia, María J., Castaño, Justo P., Gahete, Manuel D., Luque, Raúl M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6947219/ https://www.ncbi.nlm.nih.gov/pubmed/31766715 http://dx.doi.org/10.3390/jcm8122056

Ejemplares similares

Plasma ghrelin O‐acyltransferase (GOAT) enzyme levels: A novel non‐invasive diagnosis tool for patients with significant prostate cancer
por: Gómez‐Gómez, Enrique, et al.
Publicado: (2018)

Ghrelin-O-Acyltransferase (GOAT) Enzyme as a Novel Potential Biomarker in Gastroenteropancreatic Neuroendocrine Tumors
por: Herrera-Martínez, Aura D., et al.
Publicado: (2018)

A Novel Human Ghrelin Variant (In1-Ghrelin) and Ghrelin-O-Acyltransferase Are Overexpressed in Breast Cancer: Potential Pathophysiological Relevance
por: Gahete, Manuel D., et al.
Publicado: (2011)

Characterization of Ghrelin O-Acyltransferase (GOAT) in goldfish (Carassius auratus)
por: Blanco, Ayelén Melisa, et al.
Publicado: (2017)

Unleashing the Diagnostic, Prognostic and Therapeutic Potential of the Neuronostatin/GPR107 System in Prostate Cancer
por: Sáez-Martínez, Prudencio, et al.
Publicado: (2020)

The oncogenic role of the In1-ghrelin splicing variant in prostate cancer aggressiveness
por: Hormaechea-Agulla, Daniel, et al.
Publicado: (2017)

Oncogenic Role of Secreted Engrailed Homeobox 2 (EN2) in Prostate Cancer
por: Gómez-Gómez, Enrique, et al.
Publicado: (2019)

Comparative Cytotoxic Activity of Hydroxytyrosol and Its Semisynthetic Lipophilic Derivatives in Prostate Cancer Cells
por: León-González, Antonio J., et al.
Publicado: (2021)

Ghrelin O-acyltransferase (GOAT) is expressed in prostate cancer tissues and cell lines and expression is differentially regulated in vitro by ghrelin
por: Seim, Inge, et al.
Publicado: (2013)

SUN-LB056 The Pharmacological Blockade of the Splicing Factor SF3B1 Exerts Antitumor Actions in Different Endocrine-Related Cancers
por: Gahete, Manuel, et al.
Publicado: (2019)

Dysregulation of the splicing machinery is directly associated to aggressiveness of prostate cancer
por: Jiménez-Vacas, Juan M., et al.
Publicado: (2020)

Obesity and metabolic dysfunction severely influence prostate cell function: role of insulin and IGF1
por: L‐López, Fernando, et al.
Publicado: (2017)

Role of Endogenous Cortistatin in the Regulation of Ghrelin System Expression at Pancreatic Level under Normal and Obese Conditions
por: Chanclón, Belén, et al.
Publicado: (2013)

Sarcopenia and Ghrelin System in the Clinical Outcome and Prognosis of Gastroenteropancreatic Neuroendocrine Neoplasms
por: Herrera-Martínez, Yiraldine, et al.
Publicado: (2021)

THU550 The Splicing Factor SRSF6 Regulates Androgen Receptor Activity And Represents A Potential Therapeutic Target In Prostate Cancer
por: Luque, Raul M, et al.
Publicado: (2023)

In1-ghrelin, a splice variant of ghrelin gene, is associated with the evolution and aggressiveness of human neuroendocrine tumors: Evidence from clinical, cellular and molecular parameters
por: Luque, Raul M., et al.
Publicado: (2015)

Ghrelin octanoylation by ghrelin O-acyltransferase: protein acylation impacting metabolic and neuroendocrine signalling
por: Davis, Tasha R., et al.
Publicado: (2021)

Observational study comparing the accuracy/variability between the ERSPC and the PCPT risk calculators for the prediction of significant prostate cancer in patients with PSA <10 ng/mL
por: Gomez Gomez, Enrique, et al.
Publicado: (2019)

Clinical association of metabolic syndrome, C‐reactive protein and testosterone levels with clinically significant prostate cancer
por: Gómez‐Gómez, Enrique, et al.
Publicado: (2018)

Discovery of novel inhibitors of ghrelin O-acyltransferase enzyme: an in-silico approach
por: Hosseini, Faezeh Sadat, et al.
Publicado: (2022)

Dysregulation of the miRNome unveils a crosstalk between obesity and prostate cancer: miR-107 asa personalized diagnostic and therapeutic tool
por: Herrero-Aguayo, Vicente, et al.
Publicado: (2022)

SF3B1 inhibition disrupts malignancy and prolongs survival in glioblastoma patients through BCL2L1 splicing and mTOR/ß-catenin pathways imbalances
por: Fuentes-Fayos, Antonio C., et al.
Publicado: (2022)

Breast cancer is associated to impaired glucose/insulin homeostasis in premenopausal obese/overweight patients
por: Luque, Raúl M., et al.
Publicado: (2017)

Metformin and simvastatin exert additive antitumour effects in glioblastoma via senescence-state: clinical and translational evidence
por: Fuentes-Fayos, Antonio C., et al.
Publicado: (2023)

Lack of cortistatin or somatostatin differentially influences DMBA-induced mammary gland tumorigenesis in mice in an obesity-dependent mode
por: Luque, Raúl M., et al.
Publicado: (2016)

In1-ghrelin splicing variant is overexpressed in pituitary adenomas and increases their aggressive features
por: Ibáñez-Costa, Alejandro, et al.
Publicado: (2015)

Inhibition of ghrelin o-acyltransferase attenuated lipotoxicity by inducing autophagy via AMPK–mTOR pathway
por: Zhang, Shaoren, et al.
Publicado: (2018)

Splicing machinery dysregulation drives glioblastoma development/aggressiveness: oncogenic role of SRSF3
por: Fuentes-Fayos, Antonio C, et al.
Publicado: (2020)

Dysregulated splicing factor SF3B1 unveils a dual therapeutic vulnerability to target pancreatic cancer cells and cancer stem cells with an anti-splicing drug
por: Alors-Perez, Emilia, et al.
Publicado: (2021)

SUN-540 Inflammasome Components After Bariatric Surgery: Novel Targets for a Chronic Disease
por: Herrera-Martinez, Aura D, et al.
Publicado: (2020)

Effects of a 12-Week Diet versus Diet plus Aerobic and Resistance Exercise Program on Acylated and Desacylated Ghrelin, and Ghrelin O-Acyltransferase in Adolescent Girls with Obesity
por: Kim, Hyun Jun, et al.
Publicado: (2022)

Role of the clock gene Bmal1 and the gastric ghrelin-secreting cell in the circadian regulation of the ghrelin-GOAT system
por: Laermans, J., et al.
Publicado: (2015)

CE–MS-based urinary biomarkers to distinguish non-significant from significant prostate cancer
por: Frantzi, Maria, et al.
Publicado: (2019)

Altered Lipid and Salt Taste Responsivity in Ghrelin and GOAT Null Mice
por: Cai, Huan, et al.
Publicado: (2013)

Somatostatin, Cortistatin and Their Receptors Exert Antitumor Actions in Androgen-Independent Prostate Cancer Cells: Critical Role of Endogenous Cortistatin
por: Sáez-Martínez, Prudencio, et al.
Publicado: (2022)

In Situ Localization and Rhythmic Expression of Ghrelin and ghs-r1 Ghrelin Receptor in the Brain and Gastrointestinal Tract of Goldfish (Carassius auratus)
por: Sánchez-Bretaño, Aída, et al.
Publicado: (2015)

Obesity- and gender-dependent role of endogenous somatostatin and cortistatin in the regulation of endocrine and metabolic homeostasis in mice
por: Luque, Raúl M., et al.
Publicado: (2016)

Obesity Alters Gene Expression for GH/IGF-I Axis in Mouse Mammary Fat Pads: Differential Role of Cortistatin and Somatostatin
por: Villa-Osaba, Alicia, et al.
Publicado: (2015)

The GOAT-Ghrelin System Is Not Essential for Hypoglycemia Prevention during Prolonged Calorie Restriction
por: Yi, Chun-Xia, et al.
Publicado: (2012)

Trypanosoma cruzi Ikiakarora (TcIII) Draft Genome Sequence
por: Gómez, Inmaculada, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_nb7419u5n5tet7gk0ck4b1tiv9