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Circadian Activity Rhythm in Early Relapsing–Remitting Multiple Sclerosis
While relapsing–remitting is the most prevalent course of multiple sclerosis, the prognostic/predictive markers of the worsening of symptomatology are still debated. With reference to other diseases, the study of the circadian activity rhythm, according to the theoretical framework of the two-proces...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6947264/ https://www.ncbi.nlm.nih.gov/pubmed/31847439 http://dx.doi.org/10.3390/jcm8122216 |
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author | Tonetti, Lorenzo Camilli, Federico Giovagnoli, Sara Natale, Vincenzo Lugaresi, Alessandra |
author_facet | Tonetti, Lorenzo Camilli, Federico Giovagnoli, Sara Natale, Vincenzo Lugaresi, Alessandra |
author_sort | Tonetti, Lorenzo |
collection | PubMed |
description | While relapsing–remitting is the most prevalent course of multiple sclerosis, the prognostic/predictive markers of the worsening of symptomatology are still debated. With reference to other diseases, the study of the circadian activity rhythm, according to the theoretical framework of the two-process model of sleep regulation and applying functional linear modeling, proved to be useful to identify a possible marker. The usefulness of the study of circadian activity rhythm in multiple sclerosis is strengthened by recent findings indicating a potential involvement of circadian factors in the multifactorial etiopathology of the disorder. The aim of the present study was to verify whether circadian activity rhythm of early relapsing–remitting multiple sclerosis patients presents specific alterations, through functional linear modeling. Thirty-five relapsing–remitting multiple sclerosis patients (24 females; mean age ± SD = 31.51 ± 7.74) and 35 healthy controls (24 females; mean age ± SD = 31.29 ± 8.02) were enrolled. They wore an actigraph around the non-dominant wrist for one week. Relapsing–remitting multiple sclerosis patients showed a peak in motor activity around 5:00 a.m., higher than that of healthy controls. The timing of the peak in motor activity in the patients could be explained according to the hyperactive hypothalamus-pituitary-adrenal axis and higher cortisol awakening response reported in these patients. |
format | Online Article Text |
id | pubmed-6947264 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-69472642020-01-13 Circadian Activity Rhythm in Early Relapsing–Remitting Multiple Sclerosis Tonetti, Lorenzo Camilli, Federico Giovagnoli, Sara Natale, Vincenzo Lugaresi, Alessandra J Clin Med Article While relapsing–remitting is the most prevalent course of multiple sclerosis, the prognostic/predictive markers of the worsening of symptomatology are still debated. With reference to other diseases, the study of the circadian activity rhythm, according to the theoretical framework of the two-process model of sleep regulation and applying functional linear modeling, proved to be useful to identify a possible marker. The usefulness of the study of circadian activity rhythm in multiple sclerosis is strengthened by recent findings indicating a potential involvement of circadian factors in the multifactorial etiopathology of the disorder. The aim of the present study was to verify whether circadian activity rhythm of early relapsing–remitting multiple sclerosis patients presents specific alterations, through functional linear modeling. Thirty-five relapsing–remitting multiple sclerosis patients (24 females; mean age ± SD = 31.51 ± 7.74) and 35 healthy controls (24 females; mean age ± SD = 31.29 ± 8.02) were enrolled. They wore an actigraph around the non-dominant wrist for one week. Relapsing–remitting multiple sclerosis patients showed a peak in motor activity around 5:00 a.m., higher than that of healthy controls. The timing of the peak in motor activity in the patients could be explained according to the hyperactive hypothalamus-pituitary-adrenal axis and higher cortisol awakening response reported in these patients. MDPI 2019-12-15 /pmc/articles/PMC6947264/ /pubmed/31847439 http://dx.doi.org/10.3390/jcm8122216 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Tonetti, Lorenzo Camilli, Federico Giovagnoli, Sara Natale, Vincenzo Lugaresi, Alessandra Circadian Activity Rhythm in Early Relapsing–Remitting Multiple Sclerosis |
title | Circadian Activity Rhythm in Early Relapsing–Remitting Multiple Sclerosis |
title_full | Circadian Activity Rhythm in Early Relapsing–Remitting Multiple Sclerosis |
title_fullStr | Circadian Activity Rhythm in Early Relapsing–Remitting Multiple Sclerosis |
title_full_unstemmed | Circadian Activity Rhythm in Early Relapsing–Remitting Multiple Sclerosis |
title_short | Circadian Activity Rhythm in Early Relapsing–Remitting Multiple Sclerosis |
title_sort | circadian activity rhythm in early relapsing–remitting multiple sclerosis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6947264/ https://www.ncbi.nlm.nih.gov/pubmed/31847439 http://dx.doi.org/10.3390/jcm8122216 |
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