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Testicular Function of Childhood Cancer Survivors: Who Is Worse?

Background: A multi-disciplinary approach has led to an improvement in prognosis of childhood cancers. However, in parallel with the increase in survival rate, there is a greater occurrence of long-term toxicity related to antineoplastic treatment. Hypogonadism and infertility are among the most fre...

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Autores principales: Duca, Ylenia, Di Cataldo, Andrea, Russo, Giovanna, Cannata, Emanuela, Burgio, Giovanni, Compagnone, Michele, Alamo, Angela, Condorelli, Rosita A., La Vignera, Sandro, Calogero, Aldo E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6947348/
https://www.ncbi.nlm.nih.gov/pubmed/31847212
http://dx.doi.org/10.3390/jcm8122204
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author Duca, Ylenia
Di Cataldo, Andrea
Russo, Giovanna
Cannata, Emanuela
Burgio, Giovanni
Compagnone, Michele
Alamo, Angela
Condorelli, Rosita A.
La Vignera, Sandro
Calogero, Aldo E.
author_facet Duca, Ylenia
Di Cataldo, Andrea
Russo, Giovanna
Cannata, Emanuela
Burgio, Giovanni
Compagnone, Michele
Alamo, Angela
Condorelli, Rosita A.
La Vignera, Sandro
Calogero, Aldo E.
author_sort Duca, Ylenia
collection PubMed
description Background: A multi-disciplinary approach has led to an improvement in prognosis of childhood cancers. However, in parallel with the increase in survival rate, there is a greater occurrence of long-term toxicity related to antineoplastic treatment. Hypogonadism and infertility are among the most frequent endocrinological sequelae in young adult childhood cancer survivors. The aim of this study was to identify which category of patients, grouped according to diagnosis, therapy, and age at treatment, shows the worst reproductive function in adulthood. Methods: We evaluated morpho-volumetric development of the testis, endocrine function of the hypothalamic–pituitary–gonadal axis, and sperm parameters in 102 young adult childhood cancer survivors. Results: Overall, about one-third of patients showed low total testicular volume, total testosterone (TT) <3.5 ng/mL, and altered sperm count. Hodgkin’s disease, hematopoietic stem cell transplantation, and non-cranial irradiation associated to chemotherapy were risk factors for poor gonadal function. Patients treated in pubertal age showed lower total testicular volume; however, the difference was due to more gonadotoxic treatment performed in older age. Testicular volume was more predictive of spermatogenesis than follicle-stimulating hormone (FSH), while anti-Müllerian hormone (AMH) was not useful in the evaluation of testicular function of male childhood cancer survivors. Conclusions: Pre-pubertal subjects at high risk of future infertility should be candidates for testicular tissue cryopreservation.
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spelling pubmed-69473482020-01-13 Testicular Function of Childhood Cancer Survivors: Who Is Worse? Duca, Ylenia Di Cataldo, Andrea Russo, Giovanna Cannata, Emanuela Burgio, Giovanni Compagnone, Michele Alamo, Angela Condorelli, Rosita A. La Vignera, Sandro Calogero, Aldo E. J Clin Med Article Background: A multi-disciplinary approach has led to an improvement in prognosis of childhood cancers. However, in parallel with the increase in survival rate, there is a greater occurrence of long-term toxicity related to antineoplastic treatment. Hypogonadism and infertility are among the most frequent endocrinological sequelae in young adult childhood cancer survivors. The aim of this study was to identify which category of patients, grouped according to diagnosis, therapy, and age at treatment, shows the worst reproductive function in adulthood. Methods: We evaluated morpho-volumetric development of the testis, endocrine function of the hypothalamic–pituitary–gonadal axis, and sperm parameters in 102 young adult childhood cancer survivors. Results: Overall, about one-third of patients showed low total testicular volume, total testosterone (TT) <3.5 ng/mL, and altered sperm count. Hodgkin’s disease, hematopoietic stem cell transplantation, and non-cranial irradiation associated to chemotherapy were risk factors for poor gonadal function. Patients treated in pubertal age showed lower total testicular volume; however, the difference was due to more gonadotoxic treatment performed in older age. Testicular volume was more predictive of spermatogenesis than follicle-stimulating hormone (FSH), while anti-Müllerian hormone (AMH) was not useful in the evaluation of testicular function of male childhood cancer survivors. Conclusions: Pre-pubertal subjects at high risk of future infertility should be candidates for testicular tissue cryopreservation. MDPI 2019-12-13 /pmc/articles/PMC6947348/ /pubmed/31847212 http://dx.doi.org/10.3390/jcm8122204 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Duca, Ylenia
Di Cataldo, Andrea
Russo, Giovanna
Cannata, Emanuela
Burgio, Giovanni
Compagnone, Michele
Alamo, Angela
Condorelli, Rosita A.
La Vignera, Sandro
Calogero, Aldo E.
Testicular Function of Childhood Cancer Survivors: Who Is Worse?
title Testicular Function of Childhood Cancer Survivors: Who Is Worse?
title_full Testicular Function of Childhood Cancer Survivors: Who Is Worse?
title_fullStr Testicular Function of Childhood Cancer Survivors: Who Is Worse?
title_full_unstemmed Testicular Function of Childhood Cancer Survivors: Who Is Worse?
title_short Testicular Function of Childhood Cancer Survivors: Who Is Worse?
title_sort testicular function of childhood cancer survivors: who is worse?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6947348/
https://www.ncbi.nlm.nih.gov/pubmed/31847212
http://dx.doi.org/10.3390/jcm8122204
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