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Evaluation of Point Shear Wave Elastography Using Acoustic Radiation Force Impulse Imaging for Longitudinal Fibrosis Assessment in Patients with HBeAg-Negative HBV Infection

Background: Accurate assessment of hepatic fibrosis in patients with chronic HBeAg-negative Hepatitis B is of crucial importance not only to predict the long-term clinical course, but also to evaluate antiviral therapy indication. The aim of this study was to prospectively assess the utility of poin...

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Autores principales: Graf, Christiana, Mondorf, Antonia, Knop, Viola, Peiffer, Kai-Henrik, Dietz, Julia, Friess, Julia, Wedemeyer, Heiner, Buggisch, Peter, Mauss, Stefan, Berg, Thomas, Rausch, Michael, Sprinzl, Martin, Klinker, Hartwig, Hinrichsen, Holger, Bronowicki, Jean-Pierre, Haag, Sebastian, Hüppe, Dietrich, Lutz, Thomas, Poynard, Thierry, Zeuzem, Stefan, Friedrich-Rust, Mireen, Sarrazin, Christoph, Vermehren, Johannes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6947378/
https://www.ncbi.nlm.nih.gov/pubmed/31810183
http://dx.doi.org/10.3390/jcm8122101
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author Graf, Christiana
Mondorf, Antonia
Knop, Viola
Peiffer, Kai-Henrik
Dietz, Julia
Friess, Julia
Wedemeyer, Heiner
Buggisch, Peter
Mauss, Stefan
Berg, Thomas
Rausch, Michael
Sprinzl, Martin
Klinker, Hartwig
Hinrichsen, Holger
Bronowicki, Jean-Pierre
Haag, Sebastian
Hüppe, Dietrich
Lutz, Thomas
Poynard, Thierry
Zeuzem, Stefan
Friedrich-Rust, Mireen
Sarrazin, Christoph
Vermehren, Johannes
author_facet Graf, Christiana
Mondorf, Antonia
Knop, Viola
Peiffer, Kai-Henrik
Dietz, Julia
Friess, Julia
Wedemeyer, Heiner
Buggisch, Peter
Mauss, Stefan
Berg, Thomas
Rausch, Michael
Sprinzl, Martin
Klinker, Hartwig
Hinrichsen, Holger
Bronowicki, Jean-Pierre
Haag, Sebastian
Hüppe, Dietrich
Lutz, Thomas
Poynard, Thierry
Zeuzem, Stefan
Friedrich-Rust, Mireen
Sarrazin, Christoph
Vermehren, Johannes
author_sort Graf, Christiana
collection PubMed
description Background: Accurate assessment of hepatic fibrosis in patients with chronic HBeAg-negative Hepatitis B is of crucial importance not only to predict the long-term clinical course, but also to evaluate antiviral therapy indication. The aim of this study was to prospectively assess the utility of point shear wave elastography (pSWE) for longitudinal non-invasive fibrosis assessment in a large cohort of untreated patients with chronic HBeAg-negative hepatitis B virus (HBV) infection. Methods: 407 consecutive patients with HBeAg-negative HBV infection who underwent pSWE, transient elastography (TE) as well as laboratory fibrosis markers, including fibrosis index based on four factors (FIB-4), aspartate to platelet ratio index (APRI) and FibroTest, on the same day were prospectively followed up for six years. Patients were classified into one of the three groups: inactive carriers (IC; HBV-DNA <2000 IU/mL and ALT <40 U/L); grey zone group 1 (GZ-1; HBV DNA <2000 IU/mL and ALT >40 U/L); grey zone group 2 (GZ-2; HBV-DNA >2000 IU/mL and ALT <40 U/L). Results: pSWE results were significantly correlated with TE (r = 0.29, p < 0.001) and APRI (r = 0.17; p = 0.005). Median pSWE values did not differ between IC, GZ-1 and GZ-2 patients (p = 0.82, p = 0.17, p = 0.34). During six years of follow-up, median pSWE and TE values did not differ significantly over time (TE: p = 0.27; pSWE: p = 0.05). Conclusion: Our data indicate that pSWE could be useful for non-invasive fibrosis assessment and follow-up in patients with HBeAg-negative chronic HBV infection.
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spelling pubmed-69473782020-01-13 Evaluation of Point Shear Wave Elastography Using Acoustic Radiation Force Impulse Imaging for Longitudinal Fibrosis Assessment in Patients with HBeAg-Negative HBV Infection Graf, Christiana Mondorf, Antonia Knop, Viola Peiffer, Kai-Henrik Dietz, Julia Friess, Julia Wedemeyer, Heiner Buggisch, Peter Mauss, Stefan Berg, Thomas Rausch, Michael Sprinzl, Martin Klinker, Hartwig Hinrichsen, Holger Bronowicki, Jean-Pierre Haag, Sebastian Hüppe, Dietrich Lutz, Thomas Poynard, Thierry Zeuzem, Stefan Friedrich-Rust, Mireen Sarrazin, Christoph Vermehren, Johannes J Clin Med Article Background: Accurate assessment of hepatic fibrosis in patients with chronic HBeAg-negative Hepatitis B is of crucial importance not only to predict the long-term clinical course, but also to evaluate antiviral therapy indication. The aim of this study was to prospectively assess the utility of point shear wave elastography (pSWE) for longitudinal non-invasive fibrosis assessment in a large cohort of untreated patients with chronic HBeAg-negative hepatitis B virus (HBV) infection. Methods: 407 consecutive patients with HBeAg-negative HBV infection who underwent pSWE, transient elastography (TE) as well as laboratory fibrosis markers, including fibrosis index based on four factors (FIB-4), aspartate to platelet ratio index (APRI) and FibroTest, on the same day were prospectively followed up for six years. Patients were classified into one of the three groups: inactive carriers (IC; HBV-DNA <2000 IU/mL and ALT <40 U/L); grey zone group 1 (GZ-1; HBV DNA <2000 IU/mL and ALT >40 U/L); grey zone group 2 (GZ-2; HBV-DNA >2000 IU/mL and ALT <40 U/L). Results: pSWE results were significantly correlated with TE (r = 0.29, p < 0.001) and APRI (r = 0.17; p = 0.005). Median pSWE values did not differ between IC, GZ-1 and GZ-2 patients (p = 0.82, p = 0.17, p = 0.34). During six years of follow-up, median pSWE and TE values did not differ significantly over time (TE: p = 0.27; pSWE: p = 0.05). Conclusion: Our data indicate that pSWE could be useful for non-invasive fibrosis assessment and follow-up in patients with HBeAg-negative chronic HBV infection. MDPI 2019-12-02 /pmc/articles/PMC6947378/ /pubmed/31810183 http://dx.doi.org/10.3390/jcm8122101 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Graf, Christiana
Mondorf, Antonia
Knop, Viola
Peiffer, Kai-Henrik
Dietz, Julia
Friess, Julia
Wedemeyer, Heiner
Buggisch, Peter
Mauss, Stefan
Berg, Thomas
Rausch, Michael
Sprinzl, Martin
Klinker, Hartwig
Hinrichsen, Holger
Bronowicki, Jean-Pierre
Haag, Sebastian
Hüppe, Dietrich
Lutz, Thomas
Poynard, Thierry
Zeuzem, Stefan
Friedrich-Rust, Mireen
Sarrazin, Christoph
Vermehren, Johannes
Evaluation of Point Shear Wave Elastography Using Acoustic Radiation Force Impulse Imaging for Longitudinal Fibrosis Assessment in Patients with HBeAg-Negative HBV Infection
title Evaluation of Point Shear Wave Elastography Using Acoustic Radiation Force Impulse Imaging for Longitudinal Fibrosis Assessment in Patients with HBeAg-Negative HBV Infection
title_full Evaluation of Point Shear Wave Elastography Using Acoustic Radiation Force Impulse Imaging for Longitudinal Fibrosis Assessment in Patients with HBeAg-Negative HBV Infection
title_fullStr Evaluation of Point Shear Wave Elastography Using Acoustic Radiation Force Impulse Imaging for Longitudinal Fibrosis Assessment in Patients with HBeAg-Negative HBV Infection
title_full_unstemmed Evaluation of Point Shear Wave Elastography Using Acoustic Radiation Force Impulse Imaging for Longitudinal Fibrosis Assessment in Patients with HBeAg-Negative HBV Infection
title_short Evaluation of Point Shear Wave Elastography Using Acoustic Radiation Force Impulse Imaging for Longitudinal Fibrosis Assessment in Patients with HBeAg-Negative HBV Infection
title_sort evaluation of point shear wave elastography using acoustic radiation force impulse imaging for longitudinal fibrosis assessment in patients with hbeag-negative hbv infection
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6947378/
https://www.ncbi.nlm.nih.gov/pubmed/31810183
http://dx.doi.org/10.3390/jcm8122101
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