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Evaluation of Point Shear Wave Elastography Using Acoustic Radiation Force Impulse Imaging for Longitudinal Fibrosis Assessment in Patients with HBeAg-Negative HBV Infection
Background: Accurate assessment of hepatic fibrosis in patients with chronic HBeAg-negative Hepatitis B is of crucial importance not only to predict the long-term clinical course, but also to evaluate antiviral therapy indication. The aim of this study was to prospectively assess the utility of poin...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6947378/ https://www.ncbi.nlm.nih.gov/pubmed/31810183 http://dx.doi.org/10.3390/jcm8122101 |
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author | Graf, Christiana Mondorf, Antonia Knop, Viola Peiffer, Kai-Henrik Dietz, Julia Friess, Julia Wedemeyer, Heiner Buggisch, Peter Mauss, Stefan Berg, Thomas Rausch, Michael Sprinzl, Martin Klinker, Hartwig Hinrichsen, Holger Bronowicki, Jean-Pierre Haag, Sebastian Hüppe, Dietrich Lutz, Thomas Poynard, Thierry Zeuzem, Stefan Friedrich-Rust, Mireen Sarrazin, Christoph Vermehren, Johannes |
author_facet | Graf, Christiana Mondorf, Antonia Knop, Viola Peiffer, Kai-Henrik Dietz, Julia Friess, Julia Wedemeyer, Heiner Buggisch, Peter Mauss, Stefan Berg, Thomas Rausch, Michael Sprinzl, Martin Klinker, Hartwig Hinrichsen, Holger Bronowicki, Jean-Pierre Haag, Sebastian Hüppe, Dietrich Lutz, Thomas Poynard, Thierry Zeuzem, Stefan Friedrich-Rust, Mireen Sarrazin, Christoph Vermehren, Johannes |
author_sort | Graf, Christiana |
collection | PubMed |
description | Background: Accurate assessment of hepatic fibrosis in patients with chronic HBeAg-negative Hepatitis B is of crucial importance not only to predict the long-term clinical course, but also to evaluate antiviral therapy indication. The aim of this study was to prospectively assess the utility of point shear wave elastography (pSWE) for longitudinal non-invasive fibrosis assessment in a large cohort of untreated patients with chronic HBeAg-negative hepatitis B virus (HBV) infection. Methods: 407 consecutive patients with HBeAg-negative HBV infection who underwent pSWE, transient elastography (TE) as well as laboratory fibrosis markers, including fibrosis index based on four factors (FIB-4), aspartate to platelet ratio index (APRI) and FibroTest, on the same day were prospectively followed up for six years. Patients were classified into one of the three groups: inactive carriers (IC; HBV-DNA <2000 IU/mL and ALT <40 U/L); grey zone group 1 (GZ-1; HBV DNA <2000 IU/mL and ALT >40 U/L); grey zone group 2 (GZ-2; HBV-DNA >2000 IU/mL and ALT <40 U/L). Results: pSWE results were significantly correlated with TE (r = 0.29, p < 0.001) and APRI (r = 0.17; p = 0.005). Median pSWE values did not differ between IC, GZ-1 and GZ-2 patients (p = 0.82, p = 0.17, p = 0.34). During six years of follow-up, median pSWE and TE values did not differ significantly over time (TE: p = 0.27; pSWE: p = 0.05). Conclusion: Our data indicate that pSWE could be useful for non-invasive fibrosis assessment and follow-up in patients with HBeAg-negative chronic HBV infection. |
format | Online Article Text |
id | pubmed-6947378 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-69473782020-01-13 Evaluation of Point Shear Wave Elastography Using Acoustic Radiation Force Impulse Imaging for Longitudinal Fibrosis Assessment in Patients with HBeAg-Negative HBV Infection Graf, Christiana Mondorf, Antonia Knop, Viola Peiffer, Kai-Henrik Dietz, Julia Friess, Julia Wedemeyer, Heiner Buggisch, Peter Mauss, Stefan Berg, Thomas Rausch, Michael Sprinzl, Martin Klinker, Hartwig Hinrichsen, Holger Bronowicki, Jean-Pierre Haag, Sebastian Hüppe, Dietrich Lutz, Thomas Poynard, Thierry Zeuzem, Stefan Friedrich-Rust, Mireen Sarrazin, Christoph Vermehren, Johannes J Clin Med Article Background: Accurate assessment of hepatic fibrosis in patients with chronic HBeAg-negative Hepatitis B is of crucial importance not only to predict the long-term clinical course, but also to evaluate antiviral therapy indication. The aim of this study was to prospectively assess the utility of point shear wave elastography (pSWE) for longitudinal non-invasive fibrosis assessment in a large cohort of untreated patients with chronic HBeAg-negative hepatitis B virus (HBV) infection. Methods: 407 consecutive patients with HBeAg-negative HBV infection who underwent pSWE, transient elastography (TE) as well as laboratory fibrosis markers, including fibrosis index based on four factors (FIB-4), aspartate to platelet ratio index (APRI) and FibroTest, on the same day were prospectively followed up for six years. Patients were classified into one of the three groups: inactive carriers (IC; HBV-DNA <2000 IU/mL and ALT <40 U/L); grey zone group 1 (GZ-1; HBV DNA <2000 IU/mL and ALT >40 U/L); grey zone group 2 (GZ-2; HBV-DNA >2000 IU/mL and ALT <40 U/L). Results: pSWE results were significantly correlated with TE (r = 0.29, p < 0.001) and APRI (r = 0.17; p = 0.005). Median pSWE values did not differ between IC, GZ-1 and GZ-2 patients (p = 0.82, p = 0.17, p = 0.34). During six years of follow-up, median pSWE and TE values did not differ significantly over time (TE: p = 0.27; pSWE: p = 0.05). Conclusion: Our data indicate that pSWE could be useful for non-invasive fibrosis assessment and follow-up in patients with HBeAg-negative chronic HBV infection. MDPI 2019-12-02 /pmc/articles/PMC6947378/ /pubmed/31810183 http://dx.doi.org/10.3390/jcm8122101 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Graf, Christiana Mondorf, Antonia Knop, Viola Peiffer, Kai-Henrik Dietz, Julia Friess, Julia Wedemeyer, Heiner Buggisch, Peter Mauss, Stefan Berg, Thomas Rausch, Michael Sprinzl, Martin Klinker, Hartwig Hinrichsen, Holger Bronowicki, Jean-Pierre Haag, Sebastian Hüppe, Dietrich Lutz, Thomas Poynard, Thierry Zeuzem, Stefan Friedrich-Rust, Mireen Sarrazin, Christoph Vermehren, Johannes Evaluation of Point Shear Wave Elastography Using Acoustic Radiation Force Impulse Imaging for Longitudinal Fibrosis Assessment in Patients with HBeAg-Negative HBV Infection |
title | Evaluation of Point Shear Wave Elastography Using Acoustic Radiation Force Impulse Imaging for Longitudinal Fibrosis Assessment in Patients with HBeAg-Negative HBV Infection |
title_full | Evaluation of Point Shear Wave Elastography Using Acoustic Radiation Force Impulse Imaging for Longitudinal Fibrosis Assessment in Patients with HBeAg-Negative HBV Infection |
title_fullStr | Evaluation of Point Shear Wave Elastography Using Acoustic Radiation Force Impulse Imaging for Longitudinal Fibrosis Assessment in Patients with HBeAg-Negative HBV Infection |
title_full_unstemmed | Evaluation of Point Shear Wave Elastography Using Acoustic Radiation Force Impulse Imaging for Longitudinal Fibrosis Assessment in Patients with HBeAg-Negative HBV Infection |
title_short | Evaluation of Point Shear Wave Elastography Using Acoustic Radiation Force Impulse Imaging for Longitudinal Fibrosis Assessment in Patients with HBeAg-Negative HBV Infection |
title_sort | evaluation of point shear wave elastography using acoustic radiation force impulse imaging for longitudinal fibrosis assessment in patients with hbeag-negative hbv infection |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6947378/ https://www.ncbi.nlm.nih.gov/pubmed/31810183 http://dx.doi.org/10.3390/jcm8122101 |
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