Cargando…

Leptin Modulates the Expression of miRNAs-Targeting POMC mRNA by the JAK2-STAT3 and PI3K-Akt Pathways

The central control of energy balance involves a strongly regulated neuronal network within the hypothalamus and the brainstem. In these structures, pro-opiomelanocortin (POMC) neurons are known to decrease food intake and to increase energy expenditure. Thus, leptin, a peripheral signal that relays...

Descripción completa

Detalles Bibliográficos
Autores principales:	Derghal, Adel, Astier, Julien, Sicard, Flavie, Couturier, Charlène, Landrier, Jean-François, Mounien, Lourdes
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6947463/ https://www.ncbi.nlm.nih.gov/pubmed/31847355 http://dx.doi.org/10.3390/jcm8122213

Ejemplares similares

Leptin is required for hypothalamic regulation of miRNAs targeting POMC 3′UTR
por: Derghal, Adel, et al.
Publicado: (2015)

MicroRNAs in Obesity and Related Metabolic Disorders
por: Landrier, Jean-François, et al.
Publicado: (2019)

Proposal of a bioinformatics approach to predict molecular mechanisms involved in inflammatory response: case of ATRA and 1,25(OH)(2)D in adipocytes
por: Karkeni, Esma, et al.
Publicado: (2023)

Vitamin D and Obesity/Adiposity—A Brief Overview of Recent Studies
por: Bennour, Imene, et al.
Publicado: (2022)

Maternal Vitamin D Deficiency in Mice Increases White Adipose Tissue Inflammation in Offspring
por: Haroun, Nicole, et al.
Publicado: (2022)

Dielectric and Biological Characterization of Liver Tissue in a High-Fat Diet Mouse Model
por: Buisson, Clément, et al.
Publicado: (2023)

An Emerging Role of micro-RNA in the Effect of the Endocrine Disruptors
por: Derghal, Adel, et al.
Publicado: (2016)

The Role of MicroRNA in the Modulation of the Melanocortinergic System
por: Derghal, Adel, et al.
Publicado: (2017)

Proanthocyanidins potentiate hypothalamic leptin/STAT3 signalling and Pomc gene expression in rats with diet-induced obesity
por: Ibars, M, et al.
Publicado: (2017)

Botanic Origin of Propolis Extract Powder Drives Contrasted Impact on Diabesity in High-Fat-Fed Mice
por: Cardinault, Nicolas, et al.
Publicado: (2021)

Anti-Obesity Effect of Carotenoids: Direct Impact on Adipose Tissue and Adipose Tissue-Driven Indirect Effects
por: Mounien, Lourdes, et al.
Publicado: (2019)

Leptin-Induced JAK/STAT Signaling and Cancer Growth
por: Mullen, McKay, et al.
Publicado: (2016)

Circulating miRNAs as new activators of the JAK-STAT3 pathway
por: Lam, David, et al.
Publicado: (2013)

Adiponectin potentiates the acute effects of leptin in arcuate Pomc neurons
por: Sun, Jia, et al.
Publicado: (2016)

Leptin Induces Cyclin D1 Expression and Proliferation of Human Nucleus Pulposus Cells via JAK/STAT, PI3K/Akt and MEK/ERK Pathways
por: Li, Zheng, et al.
Publicado: (2012)

Retraction: Leptin Induces Cyclin D1 Expression and Proliferation of Human Nucleus Pulposus Cells via JAK/STAT, PI3K/Akt and MEK/ERK Pathways
Publicado: (2023)

Depletion of Zinc Causes Osteoblast Apoptosis with Elevation of Leptin Secretion and Phosphorylation of JAK2/STAT3
por: Lee, Jennifer K., et al.
Publicado: (2022)

Leptin Promotes the Proliferation and Neuronal Differentiation of Neural Stem Cells through the Cooperative Action of MAPK/ERK1/2, JAK2/STAT3 and PI3K/AKT Signaling Pathways
por: Tan, Ruolan, et al.
Publicado: (2023)

POMC neurons expressing leptin receptors coordinate metabolic responses to fasting via suppression of leptin levels
por: Caron, Alexandre, et al.
Publicado: (2018)

PI3K-AKT, JAK2-STAT3 pathways and cell–cell contact regulate maspin subcellular localization
por: Longhi, M. T., et al.
Publicado: (2021)

Leptin Induced TLR4 Expression via the JAK2-STAT3 Pathway in Obesity-Related Osteoarthritis
por: Jiang, Mengqi, et al.
Publicado: (2021)

Vitamin D Supplementation Improves Adipose Tissue Inflammation and Reduces Hepatic Steatosis in Obese C57BL/6J Mice
por: Marziou, Alexandra, et al.
Publicado: (2020)

Olanzapine- induced metabolic syndrome pathogenesis: Hypothalamic “leptin resistance” or “pomc resistance”?
por: Veneziani, F., et al.
Publicado: (2021)

Rosmanol induces breast cancer cells apoptosis by regulating PI3K/AKT and STAT3/JAK2 signaling pathways
por: Jiang, Dongjun, et al.
Publicado: (2021)

Somato-Dendritic Localization and Signaling by Leptin Receptors in Hypothalamic POMC and AgRP Neurons
por: Ha, Sangdeuk, et al.
Publicado: (2013)

Interplay between glucose and leptin signaling determines the strength of GABAergic synapses at POMC neurons
por: Lee, Dong Kun, et al.
Publicado: (2015)

PGC-1β-expressing POMC neurons mediate the effect of leptin on thermoregulation in the mouse
por: Delezie, Julien, et al.
Publicado: (2020)

NTRK2 activation cooperates with PTEN deficiency in T-ALL through activation of both the PI3K–AKT and JAK–STAT3 pathways
por: Yuzugullu, Haluk, et al.
Publicado: (2016)

Resveratrol provides neuroprotection by regulating the JAK2/STAT3/PI3K/AKT/mTOR pathway after stroke in rats
por: Hou, Yongying, et al.
Publicado: (2018)

Synergistic effects of thalidomide and cisplatin are mediated via the PI3K/AKT and JAK1/STAT3 signaling pathways in cervical cancer
por: Liu, Cairu, et al.
Publicado: (2022)

8-Hydroxydaidzein Downregulates JAK/STAT, MMP, Oxidative Phosphorylation, and PI3K/AKT Pathways in K562 Cells
por: Wu, Pei-Shan, et al.
Publicado: (2021)

STAT3 phosphorylation in central leptin resistance
por: Liu, Huimin, et al.
Publicado: (2021)

Downregulation of leptin inhibits growth and induces apoptosis of lung cancer cells via the Notch and JAK/STAT3 signaling pathways
por: Zheng, Xian-Jie, et al.
Publicado: (2016)

JAK-STAT3 and somatic cell reprogramming
por: Tang, Yong, et al.
Publicado: (2013)

Epileptic Neurons Know JAK/STAT3
por: Kumari, Shikha, et al.
Publicado: (2023)

Over-Expression of Leptin Receptors in Hypothalamic POMC Neurons Increases Susceptibility to Diet-Induced Obesity
por: Gamber, Kevin M., et al.
Publicado: (2012)

Magel2 Is Required for Leptin-Mediated Depolarization of POMC Neurons in the Hypothalamic Arcuate Nucleus in Mice
por: Mercer, Rebecca E., et al.
Publicado: (2013)

Correction: Somato-Dendritic Localization and Signaling by Leptin Receptors in Hypothalamic POMC and AgRP Neurons
por: Ha, Sangdeuk, et al.
Publicado: (2013)

Differential contribution of POMC and AgRP neurons to the regulation of regional autonomic nerve activity by leptin
por: Bell, Balyssa B., et al.
Publicado: (2017)

Decreased sensitivity to the anorectic effects of leptin in mice that lack a Pomc-specific neural enhancer
por: Na, Elisa S., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_0hv49l42atrqkma2r5g0rvvdal