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Atopic Eczema in Adulthood and Risk of Depression and Anxiety: A Population-Based Cohort Study

BACKGROUND: Atopic eczema is a common and debilitating condition associated with depression and anxiety, but the nature of this association remains unclear. OBJECTIVE: To explore the temporal relationship between atopic eczema and new depression/anxiety. METHODS: This matched cohort study used routi...

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Autores principales: Schonmann, Yochai, Mansfield, Kathryn E., Hayes, Joseph F., Abuabara, Katrina, Roberts, Amanda, Smeeth, Liam, Langan, Sinéad M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6947493/
https://www.ncbi.nlm.nih.gov/pubmed/31479767
http://dx.doi.org/10.1016/j.jaip.2019.08.030
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author Schonmann, Yochai
Mansfield, Kathryn E.
Hayes, Joseph F.
Abuabara, Katrina
Roberts, Amanda
Smeeth, Liam
Langan, Sinéad M.
author_facet Schonmann, Yochai
Mansfield, Kathryn E.
Hayes, Joseph F.
Abuabara, Katrina
Roberts, Amanda
Smeeth, Liam
Langan, Sinéad M.
author_sort Schonmann, Yochai
collection PubMed
description BACKGROUND: Atopic eczema is a common and debilitating condition associated with depression and anxiety, but the nature of this association remains unclear. OBJECTIVE: To explore the temporal relationship between atopic eczema and new depression/anxiety. METHODS: This matched cohort study used routinely collected data from the UK Clinical Practice Research Datalink, linked to hospital admissions data. We identified adults with atopic eczema (1998-2016) using a validated algorithm, and up to 5 individuals without atopic eczema matched on date of diagnosis, age, sex, and general practice. We estimated the hazard ratio (HR) for new depression/anxiety using stratified Cox regression to account for age, sex, calendar period, Index of Multiple Deprivation, glucocorticoid treatment, obesity, smoking, and harmful alcohol use. RESULTS: We identified 526,808 adults with atopic eczema who were matched to 2,569,030 without. Atopic eczema was associated with increased incidence of new depression (HR, 1.14; 99% CI, 1.12-1.16) and anxiety (HR, 1.17; 99% CI, 1.14-1.19). We observed a stronger effect of atopic eczema on depression with increasing atopic eczema severity (HR [99% CI] compared with no atopic eczema: mild, 1.10 [1.08-1.13]; moderate, 1.19 [1.15-1.23]; and severe, 1.26 [1.17-1.37]). A dose-response association, however, was less apparent for new anxiety diagnosis (HR [99% CI] compared with no atopic eczema: mild, 1.14 [1.11-1.18]; moderate, 1.21 [1.17-1.26]; and severe, 1.15; [1.05-1.25]). CONCLUSIONS: Adults with atopic eczema are more likely to develop new depression and anxiety. For depression, we observed a dose-response relationship with atopic eczema severity.
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spelling pubmed-69474932020-01-09 Atopic Eczema in Adulthood and Risk of Depression and Anxiety: A Population-Based Cohort Study Schonmann, Yochai Mansfield, Kathryn E. Hayes, Joseph F. Abuabara, Katrina Roberts, Amanda Smeeth, Liam Langan, Sinéad M. J Allergy Clin Immunol Pract Article BACKGROUND: Atopic eczema is a common and debilitating condition associated with depression and anxiety, but the nature of this association remains unclear. OBJECTIVE: To explore the temporal relationship between atopic eczema and new depression/anxiety. METHODS: This matched cohort study used routinely collected data from the UK Clinical Practice Research Datalink, linked to hospital admissions data. We identified adults with atopic eczema (1998-2016) using a validated algorithm, and up to 5 individuals without atopic eczema matched on date of diagnosis, age, sex, and general practice. We estimated the hazard ratio (HR) for new depression/anxiety using stratified Cox regression to account for age, sex, calendar period, Index of Multiple Deprivation, glucocorticoid treatment, obesity, smoking, and harmful alcohol use. RESULTS: We identified 526,808 adults with atopic eczema who were matched to 2,569,030 without. Atopic eczema was associated with increased incidence of new depression (HR, 1.14; 99% CI, 1.12-1.16) and anxiety (HR, 1.17; 99% CI, 1.14-1.19). We observed a stronger effect of atopic eczema on depression with increasing atopic eczema severity (HR [99% CI] compared with no atopic eczema: mild, 1.10 [1.08-1.13]; moderate, 1.19 [1.15-1.23]; and severe, 1.26 [1.17-1.37]). A dose-response association, however, was less apparent for new anxiety diagnosis (HR [99% CI] compared with no atopic eczema: mild, 1.14 [1.11-1.18]; moderate, 1.21 [1.17-1.26]; and severe, 1.15; [1.05-1.25]). CONCLUSIONS: Adults with atopic eczema are more likely to develop new depression and anxiety. For depression, we observed a dose-response relationship with atopic eczema severity. Elsevier Inc 2020-01 /pmc/articles/PMC6947493/ /pubmed/31479767 http://dx.doi.org/10.1016/j.jaip.2019.08.030 Text en © 2019 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Schonmann, Yochai
Mansfield, Kathryn E.
Hayes, Joseph F.
Abuabara, Katrina
Roberts, Amanda
Smeeth, Liam
Langan, Sinéad M.
Atopic Eczema in Adulthood and Risk of Depression and Anxiety: A Population-Based Cohort Study
title Atopic Eczema in Adulthood and Risk of Depression and Anxiety: A Population-Based Cohort Study
title_full Atopic Eczema in Adulthood and Risk of Depression and Anxiety: A Population-Based Cohort Study
title_fullStr Atopic Eczema in Adulthood and Risk of Depression and Anxiety: A Population-Based Cohort Study
title_full_unstemmed Atopic Eczema in Adulthood and Risk of Depression and Anxiety: A Population-Based Cohort Study
title_short Atopic Eczema in Adulthood and Risk of Depression and Anxiety: A Population-Based Cohort Study
title_sort atopic eczema in adulthood and risk of depression and anxiety: a population-based cohort study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6947493/
https://www.ncbi.nlm.nih.gov/pubmed/31479767
http://dx.doi.org/10.1016/j.jaip.2019.08.030
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