Alternative Lengthening of Telomeres (ALT) in Tumors and Pluripotent Stem Cells

A telomere consists of repeated DNA sequences (TTAGGG)n as part of a nucleoprotein structure at the end of the linear chromosome, and their progressive shortening induces DNA damage response (DDR) that triggers cellular senescence. The telomere can be maintained by telomerase activity (TA) in the ma...

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Detalles Bibliográficos
Autores principales: Zhao, Shuang, Wang, Feng, Liu, Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6947546/
https://www.ncbi.nlm.nih.gov/pubmed/31835618
http://dx.doi.org/10.3390/genes10121030

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