Cargando…
Periodontitis and Tooth Loss Have Negative Systemic Impact on Circulating Progenitor Cell Levels: A Clinical Study
The aim of the present study was to investigate the association and impact of periodontitis and tooth loss on a subtype of endothelial progenitor cell (EPC) levels (CD133(+)/KDR(+)). Furthermore, the objective was to determine if the periodontal status influenced CD133(+)/KDR(+) levels. In all, 88 p...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6947645/ https://www.ncbi.nlm.nih.gov/pubmed/31817862 http://dx.doi.org/10.3390/genes10121022 |
_version_ | 1783485599368347648 |
---|---|
author | Isola, Gaetano Giudice, Antonino Lo Polizzi, Alessandro Alibrandi, Angela Patini, Romeo Ferlito, Sebastiano |
author_facet | Isola, Gaetano Giudice, Antonino Lo Polizzi, Alessandro Alibrandi, Angela Patini, Romeo Ferlito, Sebastiano |
author_sort | Isola, Gaetano |
collection | PubMed |
description | The aim of the present study was to investigate the association and impact of periodontitis and tooth loss on a subtype of endothelial progenitor cell (EPC) levels (CD133(+)/KDR(+)). Furthermore, the objective was to determine if the periodontal status influenced CD133(+)/KDR(+) levels. In all, 88 patients with periodontitis and 79 healthy controls (HCs) were enrolled in the study. Enrolled patients were examined and characterized by clinical and blood sample analysis. Spearman’s correlation test was applied in order to assess the interdependence between CD133(+)/KDR(+) levels and all periodontal parameters. In order to estimate a statistically significant trend (p-trend) for ordered CD133++/KDR+ quartiles, the Jonckheere–Terpstra test was applied for all variables. Patients in the periodontitis group presented significantly lower CD133(+)/KDR(+) levels (66.4 (45.5–269.6 cells/µL)) compared to the HC group (76.7 (24.3–313.2 cells/µL), p < 0.001). Lower CD133(+)/KDR(+) levels negatively correlated with C-reactive protein (CRP), with the number of teeth, and with all periodontal parameters (p < 0.001). Moreover, there was a proportional increase in CD133+/KDR+ levels with a progressive increase in number of teeth (p-trend < 0.001), while there was a proportional decrease in CD133+/KDR+ levels with a proportional increase in clinical attachment level (CAL, p-trend = 0.003), probing depth (PD, p-trend = 0.007), and bleeding sites (bleeding on probing (BOP), p-trend < 0.001) as an extent measure of periodontitis. This study demonstrated that patients with periodontitis presented significantly lower CD133(+)/KDR(+) levels compared to HCs. Moreover, all patients presented an increase in the CD133(+)/KDR(+) EPC levels with an extended level of periodontitis and tooth loss. |
format | Online Article Text |
id | pubmed-6947645 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-69476452020-01-13 Periodontitis and Tooth Loss Have Negative Systemic Impact on Circulating Progenitor Cell Levels: A Clinical Study Isola, Gaetano Giudice, Antonino Lo Polizzi, Alessandro Alibrandi, Angela Patini, Romeo Ferlito, Sebastiano Genes (Basel) Article The aim of the present study was to investigate the association and impact of periodontitis and tooth loss on a subtype of endothelial progenitor cell (EPC) levels (CD133(+)/KDR(+)). Furthermore, the objective was to determine if the periodontal status influenced CD133(+)/KDR(+) levels. In all, 88 patients with periodontitis and 79 healthy controls (HCs) were enrolled in the study. Enrolled patients were examined and characterized by clinical and blood sample analysis. Spearman’s correlation test was applied in order to assess the interdependence between CD133(+)/KDR(+) levels and all periodontal parameters. In order to estimate a statistically significant trend (p-trend) for ordered CD133++/KDR+ quartiles, the Jonckheere–Terpstra test was applied for all variables. Patients in the periodontitis group presented significantly lower CD133(+)/KDR(+) levels (66.4 (45.5–269.6 cells/µL)) compared to the HC group (76.7 (24.3–313.2 cells/µL), p < 0.001). Lower CD133(+)/KDR(+) levels negatively correlated with C-reactive protein (CRP), with the number of teeth, and with all periodontal parameters (p < 0.001). Moreover, there was a proportional increase in CD133+/KDR+ levels with a progressive increase in number of teeth (p-trend < 0.001), while there was a proportional decrease in CD133+/KDR+ levels with a proportional increase in clinical attachment level (CAL, p-trend = 0.003), probing depth (PD, p-trend = 0.007), and bleeding sites (bleeding on probing (BOP), p-trend < 0.001) as an extent measure of periodontitis. This study demonstrated that patients with periodontitis presented significantly lower CD133(+)/KDR(+) levels compared to HCs. Moreover, all patients presented an increase in the CD133(+)/KDR(+) EPC levels with an extended level of periodontitis and tooth loss. MDPI 2019-12-07 /pmc/articles/PMC6947645/ /pubmed/31817862 http://dx.doi.org/10.3390/genes10121022 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Isola, Gaetano Giudice, Antonino Lo Polizzi, Alessandro Alibrandi, Angela Patini, Romeo Ferlito, Sebastiano Periodontitis and Tooth Loss Have Negative Systemic Impact on Circulating Progenitor Cell Levels: A Clinical Study |
title | Periodontitis and Tooth Loss Have Negative Systemic Impact on Circulating Progenitor Cell Levels: A Clinical Study |
title_full | Periodontitis and Tooth Loss Have Negative Systemic Impact on Circulating Progenitor Cell Levels: A Clinical Study |
title_fullStr | Periodontitis and Tooth Loss Have Negative Systemic Impact on Circulating Progenitor Cell Levels: A Clinical Study |
title_full_unstemmed | Periodontitis and Tooth Loss Have Negative Systemic Impact on Circulating Progenitor Cell Levels: A Clinical Study |
title_short | Periodontitis and Tooth Loss Have Negative Systemic Impact on Circulating Progenitor Cell Levels: A Clinical Study |
title_sort | periodontitis and tooth loss have negative systemic impact on circulating progenitor cell levels: a clinical study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6947645/ https://www.ncbi.nlm.nih.gov/pubmed/31817862 http://dx.doi.org/10.3390/genes10121022 |
work_keys_str_mv | AT isolagaetano periodontitisandtoothlosshavenegativesystemicimpactoncirculatingprogenitorcelllevelsaclinicalstudy AT giudiceantoninolo periodontitisandtoothlosshavenegativesystemicimpactoncirculatingprogenitorcelllevelsaclinicalstudy AT polizzialessandro periodontitisandtoothlosshavenegativesystemicimpactoncirculatingprogenitorcelllevelsaclinicalstudy AT alibrandiangela periodontitisandtoothlosshavenegativesystemicimpactoncirculatingprogenitorcelllevelsaclinicalstudy AT patiniromeo periodontitisandtoothlosshavenegativesystemicimpactoncirculatingprogenitorcelllevelsaclinicalstudy AT ferlitosebastiano periodontitisandtoothlosshavenegativesystemicimpactoncirculatingprogenitorcelllevelsaclinicalstudy |