Existing and Emerging Metabolomic Tools for ALS Research

Growing evidence suggests that aberrant energy metabolism could play an important role in the pathogenesis of amyotrophic lateral sclerosis (ALS). Despite this, studies applying advanced technologies to investigate energy metabolism in ALS remain scarce. The rapidly growing field of metabolomics off...

Descripción completa

Detalles Bibliográficos
Autores principales: Germeys, Christine, Vandoorne, Tijs, Bercier, Valérie, Van Den Bosch, Ludo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6947647/
https://www.ncbi.nlm.nih.gov/pubmed/31817338
http://dx.doi.org/10.3390/genes10121011
_version_ 1783485599851741184
author Germeys, Christine
Vandoorne, Tijs
Bercier, Valérie
Van Den Bosch, Ludo
author_facet Germeys, Christine
Vandoorne, Tijs
Bercier, Valérie
Van Den Bosch, Ludo
author_sort Germeys, Christine
collection PubMed
description Growing evidence suggests that aberrant energy metabolism could play an important role in the pathogenesis of amyotrophic lateral sclerosis (ALS). Despite this, studies applying advanced technologies to investigate energy metabolism in ALS remain scarce. The rapidly growing field of metabolomics offers exciting new possibilities for ALS research. Here, we review existing and emerging metabolomic tools that could be used to further investigate the role of metabolism in ALS. A better understanding of the metabolic state of motor neurons and their surrounding cells could hopefully result in novel therapeutic strategies.
format Online
Article
Text
id pubmed-6947647
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-69476472020-01-13 Existing and Emerging Metabolomic Tools for ALS Research Germeys, Christine Vandoorne, Tijs Bercier, Valérie Van Den Bosch, Ludo Genes (Basel) Review Growing evidence suggests that aberrant energy metabolism could play an important role in the pathogenesis of amyotrophic lateral sclerosis (ALS). Despite this, studies applying advanced technologies to investigate energy metabolism in ALS remain scarce. The rapidly growing field of metabolomics offers exciting new possibilities for ALS research. Here, we review existing and emerging metabolomic tools that could be used to further investigate the role of metabolism in ALS. A better understanding of the metabolic state of motor neurons and their surrounding cells could hopefully result in novel therapeutic strategies. MDPI 2019-12-05 /pmc/articles/PMC6947647/ /pubmed/31817338 http://dx.doi.org/10.3390/genes10121011 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Germeys, Christine
Vandoorne, Tijs
Bercier, Valérie
Van Den Bosch, Ludo
Existing and Emerging Metabolomic Tools for ALS Research
title Existing and Emerging Metabolomic Tools for ALS Research
title_full Existing and Emerging Metabolomic Tools for ALS Research
title_fullStr Existing and Emerging Metabolomic Tools for ALS Research
title_full_unstemmed Existing and Emerging Metabolomic Tools for ALS Research
title_short Existing and Emerging Metabolomic Tools for ALS Research
title_sort existing and emerging metabolomic tools for als research
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6947647/
https://www.ncbi.nlm.nih.gov/pubmed/31817338
http://dx.doi.org/10.3390/genes10121011
work_keys_str_mv AT germeyschristine existingandemergingmetabolomictoolsforalsresearch
AT vandoornetijs existingandemergingmetabolomictoolsforalsresearch
AT berciervalerie existingandemergingmetabolomictoolsforalsresearch
AT vandenboschludo existingandemergingmetabolomictoolsforalsresearch

Ejemplares similares