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Histopathologic findings after selective ophthalmic arterial injection of melphalan for retinoblastoma

PURPOSE: The aim is to describe histopathologic observations in eyes enucleated after selective ophthalmic arterial injection (SOAI) of melphalan for retinoblastoma (RB). STUDY DESIGN: This is retrospective clinical study. PATIENTS AND METHODS: Histopathologic analysis of 14 eyes (13 patients) from...

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Autores principales: Chen, Ho-Min, Ong, Sherine Jue, Chao, An-Ning, Liou, Kuan-Lyin, Jung, Shih-Ming, Kao, Ling-Yuh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6947744/
https://www.ncbi.nlm.nih.gov/pubmed/31942432
http://dx.doi.org/10.4103/tjo.tjo_119_18
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author Chen, Ho-Min
Ong, Sherine Jue
Chao, An-Ning
Liou, Kuan-Lyin
Jung, Shih-Ming
Kao, Ling-Yuh
author_facet Chen, Ho-Min
Ong, Sherine Jue
Chao, An-Ning
Liou, Kuan-Lyin
Jung, Shih-Ming
Kao, Ling-Yuh
author_sort Chen, Ho-Min
collection PubMed
description PURPOSE: The aim is to describe histopathologic observations in eyes enucleated after selective ophthalmic arterial injection (SOAI) of melphalan for retinoblastoma (RB). STUDY DESIGN: This is retrospective clinical study. PATIENTS AND METHODS: Histopathologic analysis of 14 eyes (13 patients) from May 2008 through January 2015 at Chang Gung Memorial Hospital. RESULTS: The eyes after SOAI were enucleated due to tumor viability (n = 7, 2 with vitreous hemorrhage), neovascular glaucoma (n = 4), lens drop to vitreous with total hyphema and elevated intraocular pressure (n = 1), retinal detachment (RD) progressed (n = 1), and persistent RD with phthisis change (n = 1). Almost all of the eyes showed vitreous seeding (n = 11 eyes) before treatment. After the treatment of SOAI, the histopathological examination revealed complete regression in four eyes with one was clinically diagnosed as viable tumor and progression, one with RD progression, and two as neovascular glaucoma. Six eyes showed invasion into the optic nerves, reaching the lamina cribrosa in five eyes, and six eyes with invasion into the choroid were observed. All of the cases with lamina cribrosa involvement showed tumor progression before enucleation, four cases with lamina cribrosa involvement expired later. CONCLUSION: Although some cases of RB can be controlled effectively with SOAI, but for refractory cases after SOAI, earlier decision of enucleation may be needed.
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spelling pubmed-69477442020-01-15 Histopathologic findings after selective ophthalmic arterial injection of melphalan for retinoblastoma Chen, Ho-Min Ong, Sherine Jue Chao, An-Ning Liou, Kuan-Lyin Jung, Shih-Ming Kao, Ling-Yuh Taiwan J Ophthalmol Original Article PURPOSE: The aim is to describe histopathologic observations in eyes enucleated after selective ophthalmic arterial injection (SOAI) of melphalan for retinoblastoma (RB). STUDY DESIGN: This is retrospective clinical study. PATIENTS AND METHODS: Histopathologic analysis of 14 eyes (13 patients) from May 2008 through January 2015 at Chang Gung Memorial Hospital. RESULTS: The eyes after SOAI were enucleated due to tumor viability (n = 7, 2 with vitreous hemorrhage), neovascular glaucoma (n = 4), lens drop to vitreous with total hyphema and elevated intraocular pressure (n = 1), retinal detachment (RD) progressed (n = 1), and persistent RD with phthisis change (n = 1). Almost all of the eyes showed vitreous seeding (n = 11 eyes) before treatment. After the treatment of SOAI, the histopathological examination revealed complete regression in four eyes with one was clinically diagnosed as viable tumor and progression, one with RD progression, and two as neovascular glaucoma. Six eyes showed invasion into the optic nerves, reaching the lamina cribrosa in five eyes, and six eyes with invasion into the choroid were observed. All of the cases with lamina cribrosa involvement showed tumor progression before enucleation, four cases with lamina cribrosa involvement expired later. CONCLUSION: Although some cases of RB can be controlled effectively with SOAI, but for refractory cases after SOAI, earlier decision of enucleation may be needed. Wolters Kluwer - Medknow 2019-12-13 /pmc/articles/PMC6947744/ /pubmed/31942432 http://dx.doi.org/10.4103/tjo.tjo_119_18 Text en Copyright: © 2019 Taiwan J Ophthalmol http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Chen, Ho-Min
Ong, Sherine Jue
Chao, An-Ning
Liou, Kuan-Lyin
Jung, Shih-Ming
Kao, Ling-Yuh
Histopathologic findings after selective ophthalmic arterial injection of melphalan for retinoblastoma
title Histopathologic findings after selective ophthalmic arterial injection of melphalan for retinoblastoma
title_full Histopathologic findings after selective ophthalmic arterial injection of melphalan for retinoblastoma
title_fullStr Histopathologic findings after selective ophthalmic arterial injection of melphalan for retinoblastoma
title_full_unstemmed Histopathologic findings after selective ophthalmic arterial injection of melphalan for retinoblastoma
title_short Histopathologic findings after selective ophthalmic arterial injection of melphalan for retinoblastoma
title_sort histopathologic findings after selective ophthalmic arterial injection of melphalan for retinoblastoma
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6947744/
https://www.ncbi.nlm.nih.gov/pubmed/31942432
http://dx.doi.org/10.4103/tjo.tjo_119_18
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