Cargando…

Polyphyllin VII induces apoptotic cell death via inhibition of the PI3K/Akt and NF-κB pathways in A549 human lung cancer cells

Polyphyllin VII is an active compound isolated from Paris polyphylla, which is termed Chonglou in China. The present study was designed to investigate the underlying mechanisms of the antitumor effect of Polyphyllin VII in lung cancer cells. The cytotoxic effect of Polyphyllin VII in human lung canc...

Descripción completa

Detalles Bibliográficos
Autores principales:	He, Hao, Xu, Chang, Zheng, Lei, Wang, Kaidi, Jin, Manfei, Sun, Yanping, Yue, Zhenggang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2020
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6947863/ https://www.ncbi.nlm.nih.gov/pubmed/31974591 http://dx.doi.org/10.3892/mmr.2019.10879

Ejemplares similares

Polyphyllin VII Induces an Autophagic Cell Death by Activation of the JNK Pathway and Inhibition of PI3K/AKT/mTOR Pathway in HepG2 Cells
por: Zhang, Chao, et al.
Publicado: (2016)

Polyphyllin VII Promotes Apoptosis and Autophagic Cell Death via ROS-Inhibited AKT Activity, and Sensitizes Glioma Cells to Temozolomide
por: Pang, Dejiang, et al.
Publicado: (2019)

In Vitro and In Vivo Anti-Inflammatory Effects of Polyphyllin VII through Downregulating MAPK and NF-κB Pathways
por: Zhang, Chao, et al.
Publicado: (2019)

Polyphyllin I and VII potentiate the chemosensitivity of A549/DDP cells to cisplatin by enhancing apoptosis, reversing EMT and suppressing the CIP2A/AKT/mTOR signaling axis
por: Feng, Feifei, et al.
Publicado: (2019)

Polyphyllin VII suppresses cell proliferation, the cell cycle and cell migration in colorectal cancer
por: Song, Cheng, et al.
Publicado: (2021)

Anti-angiogenesis and anti-metastasis effects of Polyphyllin VII on Hepatocellular carcinoma cells in vitro and in vivo
por: Zhang, Chao, et al.
Publicado: (2021)

Polyphyllin II inhibits liver cancer cell proliferation, migration and invasion through downregulated cofilin activity and the AKT/NF-κB pathway
por: Pang, Dejiang, et al.
Publicado: (2020)

Correction: Polyphyllin II inhibits liver cancer cell proliferation, migration and invasion through downregulated cofilin activity and the AKT/NF-κB pathway
por: Pang, Dejiang, et al.
Publicado: (2023)

Polyphyllin I Promoted Melanoma Cells Autophagy and Apoptosis via PI3K/Akt/mTOR Signaling Pathway
por: Long, Jianwen, et al.
Publicado: (2020)

Polyphyllin I induces mitophagic and apoptotic cell death in human breast cancer cells by increasing mitochondrial PINK1 levels
por: Li, Guo-Bing, et al.
Publicado: (2017)

A new agent developed by biotransformation of polyphyllin VII inhibits chemoresistance in breast cancer
por: He, Dong-Xu, et al.
Publicado: (2015)

Polyphyllin VII attenuated RANKL-induced osteoclast differentiation via inhibiting of TRAF6/c-Src/PI3K pathway and ROS production
por: Zhou, Long, et al.
Publicado: (2020)

Polyphyllin VII induces mitochondrial apoptosis by regulating the PP2A/AKT/DRP1 signaling axis in human ovarian cancer
por: Zhao, Liubiqi, et al.
Publicado: (2021)

Polyphyllin VII induces apoptosis in HepG2 cells through ROS-mediated mitochondrial dysfunction and MAPK pathways
por: Zhang, Chao, et al.
Publicado: (2016)

Fucosyltransferase VII promotes proliferation via the EGFR/AKT/mTOR pathway in A549 cells
por: Liang, Jin-xiao, et al.
Publicado: (2017)

Investigation of the Role of Neurokinin-1 Receptor Inhibition Using Aprepitant in the Apoptotic Cell Death through PI3K/Akt/NF-κB Signal Transduction Pathways in Colon Cancer Cells
por: Ghahremanloo, Atefeh, et al.
Publicado: (2021)

Doxycycline is an NF-κB inhibitor that induces apoptotic cell death in malignant T-cells
por: Alexander-Savino, Carolina V., et al.
Publicado: (2016)

Polyphyllin VII induces CTC anoikis to inhibit lung cancer metastasis through EGFR pathway regulation
por: Que, Zujun, et al.
Publicado: (2023)

Polyphyllin I Promotes Autophagic Cell Death and Apoptosis of Colon Cancer Cells via the ROS-Inhibited AKT/mTOR Pathway
por: Luo, Qihui, et al.
Publicado: (2022)

Cabazitaxel-induced autophagy via the PI3K/Akt/mTOR pathway contributes to A549 cell death
por: Huo, Ruichao, et al.
Publicado: (2016)

Polyphyllin II Induces Protective Autophagy and Apoptosis via Inhibiting PI3K/AKT/mTOR and STAT3 Signaling in Colorectal Cancer Cells
por: Li, Jun-Kui, et al.
Publicado: (2022)

Targeting macrophage priming by polyphyllin VII triggers anti-tumor immunity via STING-governed cytotoxic T-cell infiltration in lung cancer
por: Yu, Jinglu, et al.
Publicado: (2020)

Polyphyllin I Ameliorates Collagen-Induced Arthritis by Suppressing the Inflammation Response in Macrophages Through the NF-κB Pathway
por: Wang, Qiong, et al.
Publicado: (2018)

Gilteritinib induces PUMA‐dependent apoptotic cell death via AKT/GSK‐3β/NF‐κB pathway in colorectal cancer cells
por: Li, Liangjun, et al.
Publicado: (2019)

Aprepitant Promotes Caspase-Dependent Apoptotic Cell Death and G2/M Arrest through PI3K/Akt/NF-κB Axis in Cancer Stem-Like Esophageal Squamous Cell Carcinoma Spheres
por: Javid, Hossein, et al.
Publicado: (2021)

Sotetsuflavone suppresses invasion and metastasis in non-small-cell lung cancer A549 cells by reversing EMT via the TNF-α/NF-κB and PI3K/AKT signaling pathway
por: Wang, Shaohui, et al.
Publicado: (2018)

Natural Polyphyllins (I, II, D, VI, VII) Reverses Cancer Through Apoptosis, Autophagy, Mitophagy, Inflammation, and Necroptosis
por: Ahmad, Bashir, et al.
Publicado: (2021)

Isorhamnetin Induces Melanoma Cell Apoptosis via the PI3K/Akt and NF-κB Pathways
por: Duan, Ran, et al.
Publicado: (2020)

Dynamic Motile T Cells Highly Respond to the T Cell Stimulation via PI3K-Akt and NF-κB Pathways
por: Kim, Hye-Ran, et al.
Publicado: (2013)

Carboxypeptidase E/NFα1: A New Neurotrophic Factor against Oxidative Stress-Induced Apoptotic Cell Death Mediated by ERK and PI3-K/AKT Pathways
por: Cheng, Yong, et al.
Publicado: (2013)

The synergistic anticancer effect of formosanin C and polyphyllin VII based on caspase‐mediated cleavage of Beclin1 inhibiting autophagy and promoting apoptosis
por: Cui, Jingxia, et al.
Publicado: (2018)

Polyphyllin VII induces apoptosis and autophagy via mediating H(2)O(2) levels and the JNK pathway in human osteosarcoma U2OS cells
por: Li, Xiangde, et al.
Publicado: (2021)

Effects of vaspin on pancreatic β cell secretion via PI3K/Akt and NF-κB signaling pathways
por: Liu, Shiwei, et al.
Publicado: (2017)

Targeting the PI3K/AKT/mTOR/NFκB Axis in Ovarian Cancer
por: Ghoneum, Alia, et al.
Publicado: (2020)

Mulberroside A alleviates osteoarthritis via restoring impaired autophagy and suppressing MAPK/NF-κB/PI3K-AKT-mTOR signaling pathways
por: Lu, Rui, et al.
Publicado: (2023)

TEEG Induced A549 Cell Autophagy by Regulating the PI3K/AKT/mTOR Signaling Pathway
por: Shi, Lu, et al.
Publicado: (2019)

Apoptotic Cells Induce NF-κB and Inflammasome Negative Signaling
por: Grau, Amir, et al.
Publicado: (2015)

ANTITUMOR AND APOPTOTIC EFFECTS OF CUCURBITACIN A IN A-549 LUNG CARCINOMA CELLS IS MEDIATED VIA G2/M CELL CYCLE ARREST AND M-TOR/PI3K/AKT SIGNALLING PATHWAY
por: Wang, Wen-dong, et al.
Publicado: (2017)

Irisin Enhances Doxorubicin-Induced Cell Apoptosis in Pancreatic Cancer by Inhibiting the PI3K/AKT/NF-κB Pathway
por: Liu, Jiayu, et al.
Publicado: (2019)

Cajanol Sensitizes A2780/Taxol Cells to Paclitaxel by Inhibiting the PI3K/Akt/NF-κB Signaling Pathway
por: Sui, Ming, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_c69tijhnn8anjii9h79j3am2aj