A pre-existing population of ZEB2(+) quiescent cells with stemness and mesenchymal features dictate chemoresistance in colorectal cancer

BACKGROUND: Quiescent/slow cycling cells have been identified in several tumors and correlated with therapy resistance. However, the features of chemoresistant populations and the molecular factors linking quiescence to chemoresistance are largely unknown. METHODS: A population of chemoresistant qui...

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Detalles Bibliográficos
Autores principales: Francescangeli, Federica, Contavalli, Paola, De Angelis, Maria Laura, Careccia, Silvia, Signore, Michele, Haas, Tobias Longin, Salaris, Federico, Baiocchi, Marta, Boe, Alessandra, Giuliani, Alessandro, Tcheremenskaia, Olga, Pagliuca, Alfredo, Guardiola, Ombretta, Minchiotti, Gabriella, Colace, Lidia, Ciardi, Antonio, D’Andrea, Vito, La Torre, Filippo, Medema, JanPaul, De Maria, Ruggero, Zeuner, Ann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6947904/
https://www.ncbi.nlm.nih.gov/pubmed/31910865
http://dx.doi.org/10.1186/s13046-019-1505-4

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